人物生平
學習經歷
1979-1983，就讀於江西大學（今南昌大學）生物系，獲生物學學士學位。
1983-1986，就讀於江西大學生物系，獲動物學碩士學位。
1988-1990，就讀於Fordham University，獲細胞生物學碩士學位。
1991-1996，就讀於美國Albert Einstein College of Medicine，獲Ph.D.學位。
1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.
2000-2002, Assistant Professor, University of California, Riverside.
任職經歷
2002-至今，清華大學教授。
科研領域
細胞信號轉導：利用分子生物學、生物化學及細胞生物學等多學科技術手段研究TGF-β受體的調控、TGF-β和Wnt在腫瘤形成及血管形成中的作用。
代表論文
Selected Publications :
1. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG 2013 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499-510.
2. Li Z, Fei1 T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG 2012 BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.
3. Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG 2012 PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22:1467-1478.
4. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.
5. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG 2010 Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.
6. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen YG 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.
7. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.
8. Ma J, Wang Q, Fei T, Han JD, Chen YG 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.
■ Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695.
■ Huang W, Chang HY, Fei T, Wu H, Chen YG# 2007 GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26:2471-2482.
■ Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:1951-1954.
■ Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation. Journal of Biological Chemistry, 381:8607–8612.
■ Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117
■ Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002 Transforming growth factor-β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363-29368.
■ Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y. 2000 Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.
■ Massagué, J. and Chen, YG 2000 Controlling TGF-β signaling. Genes & Development, 14:627-644. (Review)
■ Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagué, J. and Nierhs, C. 1999 Silencing of TGF-β signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.
■ Chen, YG, Hata, A, Lo, R.S., Wotton, D., Shi, Y., Pavletich, N.P. and Massagué, J. 1998 Determinants of specificity in TGF-β signal transduction. Genes & Development, 12:2144-2152.
■ Chen, YG, Liu, F. and Massagué, J. 1997 Mechanism of TGF-β receptor inhibition by FKBP12. EMBO Journal, 16:3866-3876.
2011年中科院院士增選候選人
| 2011年8月，中國科學院公布了2011年中國科學院院士增選初步候選人名單。145位科技工作者入圍，其中數學物理學部21人，化學部23人，生命科學和醫學學部30人，地學部25人，信息技術科學部18人，技術科學部28人。 |
