![李陶[幹細胞工程技術領域科學家]](/img/c/570/nBnauM3XzgDO3AzN1gzNzgzNxUTMwczM3kDN0QTNwAzMwIzL4czLyYzLt92YucmbvRWdo5Cd0FmLyE2LvoDc0RHa.jpg "李陶[幹細胞工程技術領域科學家]")
研究領域
CTCF介導的染色體間相互作用 (Science)，臍帶間充質幹細胞治療對乙醯氨基酚致肝衰（Cytothrapy）， 腫瘤細胞核移植誘導再編程與異常Igf2印跡的矯正 (EMBO)，表觀遺傳性狀的修飾與癌症治療(JCI)， 腫瘤細胞中PEG1和PEG1反義基因印跡 (JBC)，胚胎幹細胞分化（Stem cells Dev.）等。[2]
社會任職
深圳中美賽爾生物科技有限公司董事長、首席科學家
李陶 深圳市幹細胞工程技術研究開發中心主任[1]
深圳北科生物科技有限公司研發部總監、IPS首席科學家[1]
“未來生命醫養科學城”首席科學家[3]
深圳市生物工程國家級領軍人物[3]
原美國史丹福大學高級研究員[1]
日本東京大學博士[1]
原日本岩手生物工學研究中心研究員[1]
科研成果
1. Jia Liu . Linggai Cao . Yue Feng . Yuhua Li . Tao Li MiR-338-3p inhibits
李陶 2. Weihong Yi, Dazhi Yang, Huang Cao, Chuang Li, Jing Han, Ji-Fan Hu, Tao Li (corresponding author) Repair of degenerative intervertebral discs in rabbits by human umbilical cord mesenchymal stem cells embedded in type I collagen hydrogel. Stem Cell Research & Therapy 2016, Vol. 1, (2) 53-63
3. Dehai Yu,Zhonghua Du,Lingling Pian,Tao Li,Xue Wen,Wei Li,Su-Jeong Kim,Jialin Xiao,Pinchas Cohen,Jiuwei Cui,Andrew R. Hoffman,and Ji-Fan Hu Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells Vol.2017, Article ID1764549
4. Yunxia Tang, Qiongshu Li, FanweiMeng, Xingyu Huang, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Jia Liu, Xiang Hu, Ji-Fan Hu, and Tao Li (corresponding author) Therapeutic Potential of HGF-Expressing Human Umbilical Cord Mesenchymal Stem Cells in Mice with Acute Liver Failure International Journal of Hepatology 2016 Vol.13 1-13
5. Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Guifang Zeng, Jia Liu, Chunfeng Wu, Tenglong Yan, Qiongshu LiJiuwei Cui, Xiang Hu, Ji-Fan Hu, Tao Li Human umbilical cord mesenchymal stem cells suppress systemic lupus erythematosus lesions by rebalancing CD4+/CD8+ cell population Stem cell Biology and Transplantation 2016 Vol.3 1-13
6. Guifang Zeng, Qiongshu Li,Hongfang Ju, Xin Zhou, Jiaolian ZhuXiaoping Zeng, Yixin He, Chan Li, Jia Liu, Chunfeng Wu, Tenglong Yan, Man Wu, Jingyi Gan, Wei Li, Jiuwei Cui, Xiang Hu, Ji-Fan Hu, Tao Li (corresponding author)Therapeutical comparison of human placenta-derived mesenchymal stem cells in the treatment of mice with acute hepatic failure Stem Cell Research & Therapy 2016 Vol.6 78-90
7. Jingyi Gan, Fanwei Meng, Xin Zhou, Chan Li, Zongcai Liu, Xiaoping Zeng, Xingen Jiang, Yuanzhi Lao, Xiangjun Zhou, Xiang Hu, Jifan Hu, Tao Li.(corresponding author) Hematopoietic rescue of radiation-induced acute death by human superoxide dismutase-modified umbilical cord mesenchymal stem cells Cytotherapy 2014 Vol.17 403-417
8. Zongcai Liu, Fanwei Meng, Chan Li, Xin Zhou, Xiaoping Zeng, Yixin He, Randall J. Mrsny, Xiang Hu, Jifan Hu, Tao Li (corresponding author) Human umbilical cord mesenchymal stem cells rescue animals from acetaminophen-induced acute liver failure. Cytotherapy 2014 16: 1207-1219
9. Zhang H, Jiao W, Sun L, Fan J, Chen M, Wang H, Xu X, Shen A, Li T, Niu B, Ge S, Li W, Cui J, Wang G, Sun J, Fan X, Hu X, Mrsny RJ, Hoffman AR, Hu JF. Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming, Cell Stem Cell. 2013 Jul 3;13(1):30-5
10. Tao Li, Ji-Fan Hu, Jianqun Ling, Thanh H. Vu, Andrew R. Hoffman.Aberrant IGF2 imprinting in human malignancy is associated with the altered CTCF-PRC2-IGF2 promoter intrachromosomal loop complex. Human Molecular Genetics 2014 33：117-128
11. Mengfei Chen ,He Zhang, Jie Wu, Liang Xu, Di Xua, Jingnan Sun, Yixin He,
李陶 12. Zhang H, Niu B, Hu JF, Ge S, Wang H, Li T, Ling J, Steelman BN, Qian G, Hoffman AR. Interruption of intrachromosomallooping by CTCF decoy proteins abrogates genomic imprinting of human insulin-like growth factor II. Journal of Cell Biology2011;193:475-487
13. Ma AN, Huang WL, Wu ZN, Hu JF, Li T, Zhou XJ, Wang YX. Induced epigenetic modifications of the promoter chromatin silence survivin and inhibit tumor growth. Biochem Biophys Res Commun. 2010;393:592-597
14. Pan YQ, He BS, Li T, Zhu C, Zhang LR, Wang B, Xu YF, Qu LL,1 Hoffman AR, Wang SK, Hu JH*. Targeted tumor gene therapy based on loss of IGF2 imprinting. Cancer Biology & Therapy 2010;10;290-298
15. Tao Li, Ji-Fan Hu, Xinwen Qiu, Jianqun Ling, Huiling Chen, Shukui Wang, Aiju Hou, Thanh H. Vu, Andrew R. Hoffman.2008 CTCF regulates allelic expression of Igf2 by orchestrating a promoter-polycomb repressive complex-2 intrachromosomal loop. Molecular Cellular Biology，Vol. 28, No. 20.
16. Xinwen Qiu, Thanh H. Vu, Qiucheng Lu, Jian Qun Ling, Tao Li, Aiju Hou, Shu Kui Wang, Hui Ling Chen, Ji Fan Hu, and Andrew R. Hoffman (2008) A Complex Deoxyribonucleic Acid Looping Configuration Associated with the Silencing of the Maternal Igf2 Allele. Molecular Endocrinology 22(6):1476–1488
17. Theresa L. Chen,Wen-Jun Shen, Xin-Wen Qiu, Tao Li, Andrew R. Hoffman and Fredric B. Kraemer (2007). Generation of novel adipocyte monolayer cultures from embryonic stem cell. Stem cells and Development, 16:371–380,
18. Hui Ling Chen*, Tao Li* (*equal contribution), Xin Wen Qiu, JieWu, Jian Qun Ling, Zhi Hong Sun, Weibo Wang, Wei Chen, Aiju Hou, Thanh H Vu, Andrew R Hoffman and Ji-Fan Hu (2006). Correction of aberrant imprinting of IGF2 in human tumors by nuclear transfer-induced epigenetic reprogramming. The EMBO Journal25, 5329–5338.
19. Jianqun Ling, Tao Li, Ji Fan Hu,1 Thanh H. Vu, Hui Ling Chen, Xin Wen Qiu, Athena M. Cherry, Andrew R. Hoffman (2006). CTCF Mediates Interchromosomal Colocalization Between Igf2/H19 and Wsb1/Nf1. Science Vol. 312: 269-272.
20. Tao Li, Thanh H.Vu, Gary A.Ulaner, Eva Littman, Jian-Qun Ling, Hui-Ling Chen, Ji-Fan Hu, Barry Behr, Linda Giudice and Andrew R. Hoffman (2005). IVF results in de novo DNA methylation and histone methylation at an Igf2-H19 imprinting epigenetic switch. Mol Hum Reprod 11(9): 631-640
21. Thanh H Vu*, Tao Li* (*equal contribution) and Andrew R Hoffman (2004). Promoter-specific histone code marks imprinting status of IGF2 receptor in human and mouse. Human Molecular Genetics 13(19):2233-2245.
22. Xiaoming Yao, Ji-Fan Hu,Tao Li, Youwen Yang, Zhihong Sun, Gary Ulaner, Thanh H Vu, and Andrew R. Hoffman (2004). Epigenetic regulation of the taxol resistance-associated gene TRAG-3 in human tumors.Cancer Genetics and Cytogenetics. 151(1):1-13
23. Tao Li, Thanh H. Vu, Gary A. Ulaner, Youwen Yang, Ji-Fan Hu and Andrew R. Hoffman (2004). Activating and silencing histone modifications form independent allelic switch regions in the imprinted Gnas gene. Human Molecular Genetics13: 741–750.
24. Youwen Yang, Ji-Fan Hu, Gary A. Ulaner, Tao Li, Xiaoming Yao, Thanh H. Vu, and Andrew R. Hoffman (2003). Epigenetic Regulation of Igf2/H19 Imprinting at CTCF Insulator Binding Sites. Journal of Cellular Biochemistry 90:1038–1055.
25. Youwen Yang*, Tao Li* (*equal contribution), Thanh H, Gary A. Ulaner, Jifan Hu and Andrew R. Hoffman (2003). The Histone Code Regulating Expression of the Imprinted Mouse Igf2r Gene. Endocrinology 144:5658–5670.
26. Thanh H. Vu*, Tao Li* (*equal contribution), Chuyen V. Nguyen and Andrew R. Hoffman (2003). Loss of Imprinting of IGF2 Sense and Antisense Transcripts in Wilms’ Tumor. Cancer Research 63: 1900–1905.
27. Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Huifan Yien, Hongqi Lu, Hadas Sharan, Xiangjun Zhou, Zhilan Zeng, Tao Li, Youwen Yang, and Andrew R. Hoffman (2003). A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis. Clinical Cancer Research. 9:2719-2726.
28. Gary A. Ulaner, Thanh H. Vu,Tao Li, Ji-Fan Hu1, Xiao-Ming Yao, Youwen Yang, Richard Gorlick, Paul Meyers, John Healey, Marc Ladanyi and Andrew R. Hoffman (2003). Loss of imprinting of IGF2 and H19 in osteosarcoma is accompanied by reciprocal methylation changes of a CTCF-binding site. Human Molecular Genetics 12: 535–549.
29. Xiaoming Yao, Ji-Fan Hu, Mark Daniels, Xingjun Zhou, Huifan Yien, Hongqi Lu, Zhilan Zeng, Tao Li, and Andrew R. Hoffman (2002). A methylated oligonucleotide inhibits IGF2 expression and enhances survival in a model of hepatocellular carcinoma.J. Clin. Invest. 111: 265–273.
30. Tao Li, Thanh H. Vu, Kok-Onn. Lee, Chuyen V. Nguyen , Huy Q. Bui, Zhi-Lan Zeng, Binh T. Nguyen, Ji-Fan Hu, Susan K. Murphy, Randy L. Jirtle, and Andrew R. Hoffman (2002). Imprinted PEG1/MEST Antisense Expressed Predominantly in Human Testis and in Mature Spermatozoa. Journal of Biological Chemistry 16:13518-13527.
31. Killian JK, Nolan CM, Wylie AA, Li T, Vu TH, Hoffman AR, Jirtle RL (2001). Divergent evolution in M6P/IGF2R imprinting from the Jurassic to the Quaternary. Human Molecular Genetics 10:1721-1728.
32. Tao Li, Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Jifan Hu and Andrew Hoffman (2000). Tissue-specific expression of antisense and sense transcript at the imprinted Gnas locus.Genomics 69: 295-304.
33. Ji-fan Hu, Jung Pham, Indiral Dey, Tao Li, Thanh H. Vu and Andrew R. Hoffman (2000). Allele-specific histone Acetylation accompanies genomic imprinting of the insulin-like growth factor II receptor gene.Endocrinology. 141: 4428-35.
34. Tao Li, Thanh H. Vu, Danielle Nguyen, Binh T. Nguyen, Xiaoming Yao, Jifan Hu and Andrew Hoffman (2000). Symmetric and Asymmetric DNA methylation in the Human IGF2-H19 imprinted region. Genomics. 64, 132-143.
35. Okamura K, Hagiwara-Takeuchi Y, Li T, Vu TH, Hirai M, Hattori M, Sakaki Y, Hoffman AR, Ito T. (2000). Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.Genome Research. 10: 1878-1889.
36. Hu JF, Balaguru KA, Ivaturi RD, Oruganti H, Li T, Nguyen BT, Vu TH and Hoffman AR (1999). Lack of reciprocal genomic imprinting of sense and antisense RNA of mouse insulin-like growth factor II receptor in the central nervous system. Biochem Biophys Res Commun. 257: 604-608.[1]
InJapan
1. Tao Li, T. Aoki, N. Kameya, T. Tata, I. Nakamura (1998). Molecular analysis of expressed rice genes induced by infection of rice blast fungus. Japan. J. Breed. 48, Suppl. 1: 122.
2. Tao Li, Nanako Kameya, Yoshimichi Hukuta, Ikuo Nakamura (1997). Molecular cloning and linkage analysis of OSDIM cDNA in rice. Rice Genetics Newsletter 14: 130-133.
3. Tao Li, N. Kameya, T. Takano, Z. You, M. Yamada1 (1997). Structure analysis and expression of DIM gene in rice. Japan. J. Breed. 48, Suppl. 2: 122.
4. Tao Li N. Kameya, Y. Fukuta, H. Kitano, I. Nakamura (1997). Molecular analysis of DIM (diminuto) gene in rice. Japan. J. Breed. 47, Suppl. 1: 239.
5. Aoki, T., N. Kameya, T. Li, I. Nakamura (1996). cDNA clones encoding polysaccharide-modifying enzymes in elongating internodes of rice ao mutant. Japan. J. Breed. 46, Suppl. 2: 128.
6. Tao Li, Tetsuo Takano and Keisuke Kitamura (1995). Cloning of Glym Bd30K genes for an allergenic protein in azukibean. Japan. J. Breed. 45, Suppl. 2:454.
7. Takano Tetsuo, Tao Li and Keisuke Kitamura (1995). Cloning of the genes for an allergenic protein in soybean. Japan. J. Breed. 45, Suppl. 1: 27.
8. Tao Li, Tetsuo Takano and Keisuke Kitamura (1995). Distribution of a soybean allergic protein (Gly m Bd30K) and its gene in legume species. Japan. J. Breed. 45, Suppl. 1: 268.
9. Tao Li, Tetsuo Takano, Nagamura Atsusi and Genkichi Takeda (1993). Linkage analysis of rice lactate dehydrogenase gene. Rice Genetics Newsletter 1: 109-111.
10. Tao Li, Tetsuo Takano, Nagamura Atsusi and Genkichi Takeda (1994). Characterization and RFLP mapping of rice lactate dehydrogenase gene. Japan. J. Breed. 44, Suppl. 1: 19.
11. Tao Li, Tetsuo Takano, Hideo Matsumura and Genkichi Takeda (1993). Molecular cloning of rice lactate dehydrogenase cDNA. Japan. J. Breed. Vol. 43 No.1: 129-133.
12. Tao Li, Tetsuo Takano, Hideo Matsumura and Genkichi Takeda (1993). Anaerobic expression and structural analysis of rice lactate dehydrogenase gene. Japan. J. Breed. 43, Suppl. 2: 38.
13. Tao Li, Tetsuo Takano, Hideo Matsumura and Genkichi Takeda (1993). Molecular cloning of rice lactate dehydrogenase cDNA and its gene. Japan. J. Breed. 43, Suppl. 1: 84.
14. Hideo Matsumura, Tao Li, Tetsuo Takano and Genkichi Takeda (1992). Lactate dehydrogenase (LDH) in rice under anaerobic condition.Japan. J. Breed. 42, Suppl. 2: 292-293.
15. Kadowaki K., S., Kazama, Tao Li, T. and K. Harada (1990). Analysis of a chimeric ATPase subunit 6 gene generated by intramolecular recombination in rice mitochondria. Japan. J. Breed. 40, Suppl. 2: 138-139.[1]
人物影響
李陶博士從事生物醫學理論研究及產業轉化近30年，先後服務多家國際知名科研機構和行業龍頭企業，率先對臍帶間充質幹細胞進行基因改造，解決了多個關鍵性工藝環節中的重大技術難題。
李陶博士在工程化幹細胞系的構建和新型腫瘤治療技術開發、腫瘤靶向治療新靶點的篩查等新產品、新技術領域的研究水平和研究成果都處於國際前列。
近期以來，依託生命原點公司承建的河北省幹細胞庫和河北省細胞組織低溫生物保存套用工程技術研究中心兩大研發平台，李陶帶領團隊在幹細胞工程技術開發及臨床轉化研究領域取得重大進展，率先建立了臍帶間充質幹細胞工程化技術平台，構建了多個基因修飾的臍帶間充質幹細胞系，完成了工程化幹細胞移植治療急性肝衰、肝硬化的藥效學研究及治療系統性紅斑狼瘡、心肌梗塞的臨床前有效性研究，為臍帶間充質幹細胞製劑的開發、規模化生產製備及臨床套用攻克了多個關鍵性工藝難題，相關核心技術正在申請國家發明專利。[4]
部分專利
1、ZL200680046641.4 體內和體外再生細胞的方法
2、ZL201110243239.8 細胞轉核誘導體細胞成多能二倍體幹細胞的方法
3、ZL201110221115.X 單個核細胞培養液
4、ZL201110243239.8 通過mRNA誘導體細胞為多能幹細胞的方法
5、ZL201010593844.3 一種高效誘導人類體細胞重編程為多潛能幹細胞的方法
6、201410836460.8 發明專利經血間充質幹細胞的培養方法
7、201410841610.4 一種可用於肝衰竭治療的經HGF基因修飾的UCMSC製備方法
8、201410795197.2 一種製備蛻膜間充質幹細胞的方法
9、201410841531.3 牙齒來源間充質幹細胞體外分離與培養方法
10、201410795200.0 一種製備絨毛膜間充質幹細胞的方法
11、2015109740167 一種抗CD16A和抗MUC1抗原的雙特異性抗體
12、201510963795. 一種用於免疫治療的EB病毒LMP2A串聯表位肽及其套用
13、201611066874.2 CD16A/GPC3雙抗病慢病毒表達載體及其構建方法和套用
14、201611266589.5 一種抗原表位肽組合物及其使用
15、PCT/US2006/040723 Methods for rejuvenating cells in vitro and in vivo[4]
參考資料
1. 我校引進海外高層次人才取得突破性進展 ．東北林業大學新聞網．2013-09-04[引用日期2018-01-27]
2. 核心團隊-李陶 Ph.D. ．凱薩琳=幹細胞[引用日期2018-01-27]
3. “泰華細胞”迎來四川省副省長彭宇行視察工作 ．財經網[引用日期2018-01-27]
4. 為建設現代省會經濟強市貢獻高端智力——聚焦高層次科技創新創業人才 ．河北新聞網．2017-11-04[引用日期2018-01-27]
