陳峰[北京大學工學院副院長]

陳峰，北京大學工學院副院長 負責工學院研究生教育， 講席教授(國家 “千人計畫” 獲得者)食品與生物資源工程研究所所長。

背景資料

1983年畢業於華南理工大學。美國醫學與生物工程院院士，英國皇家化學會會士，國際食品科學院院士 。現任北京大學終身講席教授、中國食品科技學會功能食品分會常務副理事長兼秘書長，兼任北京大學工學院食品與生物資源工程研究所所長。國家“千人計畫”獲得者, 曾入選教育部“長江學者”和中科院 “百人計畫”。陳峰1993年畢業於澳大利亞昆士蘭大學化學工程系，獲生化工程博士學位, 澳大利亞註冊工程師。曾任香港大學終身教授兼任植物學系系主任及生物科學學院執行院長。陳峰的研究工作主要集中在微藻生物工程（包括微藻生物能源）、功能食品、生化工程及生物資源工程等領域。率先提出利用異養方式規模化高密度培養微藻以生產高附加值功能性食品成分及藻類生物能源（例如，脂質），他同時將研究擴展到其它微生物和植物資源的開發及功能性成分研究等領域。迄今已在國際學術期刊（SCI）發表200餘篇研究論文和綜述(SCI引用愈5000次,H-index 40)、專箸4本、美國及中國專利共6項。多次在國際學術會議作大會特邀發言, 多次組織國際學術會議。 被Essential Science Indicators評為“Highly Cited Scientist” (top 1%)。 曾獲香港大學“傑出青年研究獎”、“傑出研究生導師獎”、“法國-香港聯合研究獎”、“首屆中國食品科技傑出中青年獎”、2008年被選為“美國醫學和生物工程院（AIMBE）院士”、2010年獲“美國化學工程師學會大會獎”，2011年被選為“英國皇家化學會會士”。陳峰還兼任英國皇家化學會期刊Food & Function副主編和另外4個國際學術期刊編委(Process Biochemistry, Journal of Applied Phycology, Biotechnology Letters, Journal of Agricultural and Food Chemistry)。

教育經歷

1993年7月 澳大利亞 昆士蘭大學 博士 1990年12月 澳大利亞 昆士蘭大學 碩士 1983年7月 華南工學院(現華南理工大學) 學士

研究領域

微藻生物工程（包括微藻生物能源） 生物資源工程 功能食品 生化工程

部分著作及論文

I. Book1. Chen, F. & Jiang, Y. (eds) (1999). Microalgal Biotechnology. China Light Industry Press, Beijing, 348 pp. 2. Chen, F. & Jiang Y. (eds) (2001). Algae and their Biotechnological Potential. Kluwer Academic Publishers, Dordrecht, the Netherlands, 316 pp. 3. Chen, F. & Whitton, B. A. (eds) (2001). Special Issue of Journal of Applied Phycology, Vol. 3, No. 4., Kluwer Academic Publishers, Dordrecht, the Netherlands, 110 pp.4. Chen, F., Li, J.R., Hu, X.S., Liu, X., Meng S.H. & Shao, W. (2002). Modern Biological & Food Technology. China Light Industry Press, Beijing, 304 pp. II. PatentsSix patents in total (including Chinese patents and U.S. patents, etc.). III. Full SCI Journal Publication List KEY: * = Corresponding Author (Senior Author). IF = 5-Year Impact Factor (ISI Journal Citation Reports 2011) Total Citations: > 500 0 (H-index: 40 )235. Liu, J., Sun, Z., Zhong, Y.J., Huang, J.C., Hu, Q. & Chen, F.* (2012). Stearoyl-acyl carrier protein desaturase gene from the oleaginous microalga Chlorella zofingiensis: cloning, characterization and transcriptional analysis. Planta (in press). (IF: 3.420)234. Guo, Y.J., Deng, G.F., Xu, X.R., Wu, S., Li, S., Xia, E.Q., Li, F., Chen, F., Ling, W.H. & Li, H.B. (2012). Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food & Function (in press). (IF: 1.179)233. Lu, N., Wei, D., Jiang, X.L. & Chen, F. (2012). Fatty acids profiling and biomarker identification in snow alga Chlamydomonas nivalis by NaCl stress using GC/MS and multivariate statistical analysis. Analytical Letters (in press). (IF: 1.107)232. Zhu, Q., Zhang, N.Q., Lau, C.F., Chao, J.F., Sun, Z., Chang, R.C.C., Chen, F. & Wang, M.F. (2012). In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple. Food Chemistry (in press). (IF: 4.268)231. Lu, N., Wei, D., Jiang, X.L., Chen, F. & Yang, S.T. (2012). Regulation of lipid metabolism in the snow alga Chlamydomonas nivalis in response to NaCl stress: an integrated analysis by cytomic and lipidomic approaches. Process Biochemistry, 47, 1163-1170. (IF: 3.225)230. Huang, J.C., Zhong, Y.J., Sandmann, G. , Liu, J. & Chen, F.* (2012). Cloning and selection of carotenoid ketolase genes for the engineering of high-yield astaxanthin in plants. Planta (in press). (IF: 3. 420 )229. Sun, Z., Chen, J.N., Ma, J.Y., Jiang, Y., Wang, M.F. & Ren, G.X. & Chen, F.* (2012). Cynarin-rich sunflower ( Helianthus annuus) sprouts possess both antiglycative and antioxidant activities. Journal of Agricultural and Food Chemistry, 60, 3260-3265. (IF: 3.239 )228. Sun, Z. & Chen, F.* (2012). Evaluation of the green alga Chlorella pyrenoidosa for management of diabetes. Journal of Food and Drug Analysis, 20 (suppl. 1), 246-249. ( IF: 0.803).227. Lu, N., Wei, D., Chen, F. & Yang, S.T. (2012). Lipidomic profiling and discovery of lipid biomarkers in snow alga Chlamydomonas nivalis by salt stress. European Journal of Lipid Science and Technology, 114, 253-265. (IF: 2.006)226. Liu, J. Huang, J.C., Jiang, Y. & Chen, F.* (2012). Molasses-based growth and production of oil and astaxanthin by Chlorella zofingiensis. Bioresource Technology, 107, 393-398. (IF: 5.352)225. Pahl, S.L., Lewis D.M., King, K.D. & Chen, F. (2011). Heterotrophic growth and nutritional aspects of the diatom Cyclotella cryptica (Bacillariophyceae): effect of nitrogen source and concentration. Journal of Applied Phycology, 24, 301-307. (IF: 2.239 )224. Xu, Y., Ching, Y.P., Zhou, Y., Chiu, J.F., Chen, F.*, & He, Q.Y. (2011). Multiple pathways were involved in Tubeimoside-1-induced cytotoxicity of Hela cells. Journal of Proteomics, 75, 491-501. (IF: 4.906 )223. Peng, X.F., Ma, J.Y., Chen, F. & Wang, M.F. (2011). Naturally occurring inhibitors against the formation of advanced glycation endproducts. Food & Function, 2, 289-301 (new journal, included by ISI). (IF: 1.179)222. Ma, J.Y., Peng, X.F., Zhang, X.C., Chen, F. & Wang, M.F. (2011). Dual effects of phloretin and phloridzin on the glycation induced by methylglyoxal in model systems. Chemical Research in Toxicology, 24, 1304-1311. (IF: 3. 969 )221. Chen, J.N., Jiang, Y., Ma, K.Y., Chen, F. & Chen, Z.Y. (2011). Microalga decreases plasma cholesterol by down-regulation of intestinal NPC1L1, hepatic LDL receptor and HMG-CoA reductase. Journal of Agricultural and Food Chemistry, 59, 6790-6797. (IF: 3. 239 )220. Zhu, Q., Sun, Z., Jiang, Y., Chen, F. & Wang, M.F. (2011). Acrolein scavengers: reactivity, mechanism and impact on health. Molecular Nutrition & Food Research, 55, 1375-1390. (IF: 4. 579 )219. Sun, Z., Liu, J., Zeng, X.H., Huangfu, J.Q., Jiang, Y., Wang, M.F. & Chen, F.* (2011). Protective actions of microalgae against endogenous and exogenous advanced glycation endproducts (AGEs) in human retinal pigment epithelial cells. Food & Function, 2, 251-258. (new journal, included by ISI) (IF: 1.179)218. Zhong, Y.J., Huang, J.C., Liu, J., Li, Y., Jiang, Y., Xu, Z.F., Sandmann, G. & Chen, F.* (2011). Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. Journal of Experimental Botany, 62，3659-3669 ( IF: 5.480)217. Wu, Z.Y., Chen, G.Q., Chong, S.K., Mak, N.K., Chen F. & Jiang Y. (2010). Ultraviolet-B radiation improves astaxanthin accumulation in green microalga Haematococcus pluvialis. Biotechnology Letters, 32, 1911-1914. (IF: 1. 964 )216. Leung, D.Y.C., Tsui, J.K.Y., Chen, F., Yip, W.K., Vrijmoed L.L.P. & Liu C.H. (2011). Effects of urban vegetation on urban air quality. Landscape Research, 36, 173-188. (IF: 1.075 ) 215. Xu, J., Li, M., Mak, N.K., Chen F.& Jiang Y. (2011). Triphenyltin induced oxidative stress and antioxidative responses in the green alga Scenedesmus quadricauda (Chlorophyceae). Ecotoxicology, 20, 73-80. (IF: 3.185 ) .214. Sun, Z., Liu, J., Zeng, X.H., Huangfu, J.Q., Jiang, Y., Wang, M.F. & Chen, F.* (2011). Astaxanthin is responsible for antiglycoxidative properties of microalga Chlorella zofingiensis. Food Chemistry, 126, 1629-1635. (IF: 4.268 )213. Liu, J., Huang, J.C., Fan, K.W., Jiang, Y. & Chen, F. * (2011). Differential lipid and fatty acid profiles of photoautotrophic and heterotrophic Chlorella zofingiensis: Assessment of algal oils for biodiesel production. Bioresource Technology, 102, 106-110. (IF: 5.352)212. Liu, J., Fan, K.W., Huang, J.C., Zhong, Y.J., Sun, Z., Jiang, Y. & Chen, F. * (2010). Production potential of Chlorella zofingiensis as a feedstock for biodiesel. Bioresource Technology, 101, 8658-8663. (IF: 5.352) 211. Peng, X.F., Ma, J.Y., Chao, J.F., Chang, R., Li, E., Chen, F .; Wang, M.F. (2010). Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption. Journal of Agricultural and Food Chemistry, 58, 6692-6696. (IF: 3. 239 )210. Chen, G.Q., Fan, K.W., Lu, F.P., Li, Q., Aki, T., Chen, F. & Jiang, Y. (2010). Optimization of nitrogen source for enhanced production of squalene from thraustochytrid Aurantiochytrium sp. New Biotechnology, 27, 382-389. ( IF: 2.867 ).209. Zeng, X.H., Kong, R., Cheng, K.W., Du, Y.G., Tang, Y.S., Chu, I., Lo, C., Sze, K.H., Chen, F. & Wang, M.F. (2010). Direct trapping of acrylamide as a key mechanism for niacin’s inhibitory activity in carcinogenic acrylamide formation. Chemical Research in Toxicology, 23, 802-807. (IF: 3. 969 )208. Liu, J., Zhong, Y.J., Sun, Z., Huang, J.C., Jiang, Y., Sandmann, G. & Chen, F.* (2010). One amino acid substitution in phytoene desaturase makes Chlorella zofingiensis resist to norflurazon and enhance the biosynthesis of astaxanthin. Planta, 232, 61-67. (IF: 3.4 20 )207. Fan, K.W., Aki, T., Chen, F. & Jiang, Y. (2010). Enhanced production of squalene in the microalga Aurantiochytrium mangrovei by medium optimization and the treatment of terbinafine. World Journal of Microbiology & Biotechnology, 26, 1303-1309. (IF: 1. 602 ) 206. Li, Y.T., Sommerfeld, Chen, F.* & Hu, Q. (2010). Effect of photon flux densities on regulation of carotenogenesis and cell viability of Haematococcus pluvialis (Chlorophyceae). Journal of Applied Phycology, 22, 253-263. (IF: 2.239 )205. Pahl, S.L., Lewis, D.M., Chen, F. & King, K.D. (2010). Heterotrophic growth and nutritional aspects of the diatom Cyclotella cryptica (Bacillariophyceae): Effect of some environmental factors. Journal of Bioscience and Bioengineering, 109, 235-239. (IF: 2.1 49 )204. Zeng, X.H., Cheng, K.W., Du, Y.G., Kong, R., Lo, C., Chu, I.K., Chen, F. & Wang, M.F. (2010). Activities of hydrocolloids as inhibitors of acrylamide formation in model systems and fried potato strips. Food Chemistry, 121, 424-428. (IF: 4.268)203. Chen, G.Q., Xiang, W.Z., Lau, C.C., Peng, J., Qiu, J.W., Chen, F. & Jiang, Y. (2010). A comparative analysis of lipid and carotenoid composition of the gonads of Anthocidaris crassispina, Diadema setosum and Salmacis sphaeroides. Food Chemistry, 120, 973-977. (IF: 4.268 )202. Pahl, S.L., Lewis M.D., Chen, F. & King, K.D. (2010). Growth dynamics and the proximate biochemical composition and fatty acid profile of the heterotrophically grown diatom Cyclotella cryptica. Journal of Applied Phycology, 22, 165-171. (IF: 2.239 )201. Law, B.Y.K., Wang, M.F., Ma, D.L., Al-Mousa, F., Michelangeli, F., Cheng, S.H., Ng, M.H.L., To, K.F., Mok, A.Y.F., Ko, R. Y.Y., Lam, S.K.L., Chen, F., Che, C.M., Chiu, P. Ko, B.C.B. (2010). Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Molecular Cancer Therapeutics, 9, 718-730. (IF: 5. 390 )200. Sun, Z., Peng, X.F., Fan, K.W., Liu, J., Wang, M.F. & Chen, F.* (2010). Inhibitory effects of microalgal extracts on the formation of advanced glycation endproducts (AGEs). Food Chemistry, 120, 261-267. (IF: 4.268 )199. He, H.Z., Chen, F., Li, H.S., Xiang, W.Z., Li, Y.J. & Jiang, Y. (2010). Effect of iron on growth, biochemical composition and paralytic shellfish poisoning toxins production of Alexandrium tamarense. Harmful Algae, 9, 98-104. (IF: 3.463 )198. Ma, J.Y., Peng, X.F., Cheng, K.W., Kong, R., Chu, I.K., Chen, F. & Wang, M.F. (2010). Effects of melamine on the Maillard reaction between lactose and phenylalanine. Food Chemistry, 119, 1-6. (IF: 4.268)197. Huang, G.H., Chen, F.*, Wei, D., Zhang, X.W. & Chen, G. (2010). Biodiesel production by microalgal biotechnology. Applied Energy, 87, 38-46. (IF: 4.456), <, /F, ONT>196. Peng, X.F., Ma, J.Y., Cheng, K.W., Jiang, Y., Chen, F. & Wang, M.F. (2010). The effects of grape seed extract fortification on the antioxidant activity an, d quality at, tributes of bread. Food Chemistry, 119, 49-53. (IF: 4.268 )195. Cheng, K.W., Wong, C.C., Wang, M., He, Q.Y., Chen, F. * (2010). Identification and characterization of molecular targets of natural products by mass spectrometer. Mass Spectrometry Reviews, 29, 126-155. (IF: 1 1 . 676 )194. Zhu, Q., Zheng, Z.P., Cheng, K.W., Wu, J.J., Tang, Y.S., Sze, K.H., Chen, F. & Wang, M.F. (2009). Natural polyphenols as direct trapping agents of lipid peroxidation-derived acrolein and 4-hydroxy- trans-2-nonenal. Chemical Research in Toxicology, 22, 1721-1727. (IF: 3. 969 )193. Tsui, J.K.Y., Guenther, A., Yip, W.K. & Chen, F.* (2009). A biogenic volatile organic compound emission inventory for Hong Kong. Atmospheric Environment, 43, 6442-6448. (IF: 3. 742 )192. Cheng, K.W., Zeng, X.H. Tang, Y.S., Wu, J.J., Liu, Z.W., Sze, K.H., Chu, I.K., Chen, F. & Wang, M.F. (2009). Inhibitory mechanism of naringenin against carcinogenic acrylamide formation and non-enzymatic browning in Maillard model reactions. Chemical Research in Toxicology, 22, 1483-1489. (IF: 3. 969 )191. Fan, K.W., Jiang, Y., Ho, L.T. & Chen, F.* (2009). Differentiation in fatty acid profiles of pigmented and non-pigmented Aurantiochytrium isolated from Hong Kong mangroves. Journal of Agricultural and Food Chemistry, 57, 6334-6341. (IF: 3.239)190. Huang, G.H., Chen, G. & Chen, F. (2009). Application of Nile red in rapid screening of enhanced lipid production in Chlorella. Biomass & Bioenergy, 33, 1386-1392. (IF: 4.624 )189. Xu, Y., Chiu, J.F., He, Q.Y. & Chen, F.* (2009). Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways. Journal of Proteome Research, 8, 1585-1593. (IF: 5. 413 )188. Zeng, X.H., Cheng, K.W., Jiang, Y., Lin, Z.X., Shi, J.J., Ou, S.Y., Chen, F. & Wang, M.F. (2009). Inhibitory of acrylamide formation by vitamins in model reactions and fried potato strips. Food Chemistry, 116, 34-39. (IF: 4.268 )187. Chen, T., Wei, D., Chen, G., Wang, Y. & Chen, F.* (2009). Employment of organic acids to enhance astaxanthin formation in heterotrophic Chlorella zofingiensis. Journal of Food Processing and Preservation, 33, 271-284 (invited paper). (IF: 0. 714 )186. Li, H.B., & Chen , F. (2009). Separation and purification of epimedin A, epimedin B, epimedin C and icariin from the medicinal herb Epimedium brevicornum Maxim by dual-mode high-speed counter-current chromatography. Journal of Chromatographic Science, 47, 337-340. (IF: 0.955)185. Xu, X.R., Li, S.X., Li, X.Y., Gu, J.D., Chen , F ., Li, X.Z. & Li , H . B. (2009). Degradation of n-butyl benzyl phthalate using TiO/UV. Journal of Hazardous Materials, 164, 527-532. (IF: 4.553)184. Zhu, Q., Liang, C.P., Cheng, K.W., Peng, X.F., Lo, C.Y., Shahidi, F., Chen, F., Ho, C.T. & Wang, M.F. (2009). Trapping effects of green and black tea extracts on peroxidation-derived carbonyl substances of seal blubber oil. Journal of Agricultural and Food Chemistry, 57, 1065-1069. (IF: 3. 239 )183. Wei, D., Chen, F., Chen, G., Zhang, X.W., Liu, L.J. & Zhang, H. (2008). Enhanced production of lutein in heterotrophic Chlorella protothecoides by oxidative stress. Science in China Series C - Life Sciences, 51, 1088-1093. (IF: 1.148 )182. Peng, J., Xiang, W.Z., Tang, Q.M., Sun, N. Chen, F. & Yuan, J.P. (2008). Comparative analysis of astaxanthin and its esters in the mutant E1 of Haematococcus pluvialis and other green algae by HLPC with a C30 column. Science in China Series C - Life Sciences, 51, 1108-1115. (IF: 1.148 )181. Li, Y.T., Huang, J.C., Sandmann, G. & Chen, F.* (2008). High-light and sodium chloride stress differently regulate the biosynthesis of astaxanthin in Chlorella zofingiensis (Chlorophyceae). Journal of Phycology, 45, 635-641. (IF: 2. 729 )180. Yao, Y., Chen, F., Wang, M.F., Wang, J.S. & Ren, G.X. (2008). Antidiabetic activity of mung bean extracts in diabetic KK-A mice. Journal of Agricultural and Food Chemistry, 56, 8869-8873. (IF: 3. 239 )179. Yao, Y., Shan, F., Bian, J.S., Chen, F., Wang, M.F. & Ren, G.X. (2008). D- chiro-inositol enriched tartary buckwheat bran extract lowers the blood glucose level in KK-A mice. Journal of Agricultural and Food Chemistry, 56, 10027-10031. (IF: 3.239)178. Cheng, K.W., Wong, C.C., Chao, J., Lo, C., Chen, F ., Chu, I.K., Che, C., Ho, C.T., Wang, M.F. (2009). Inhibition of mutagenic PhIP formation by epigallocatechin gallate via scavenging of phenylacetaldehyde. Molecular Nutrition & Food Research, 53, 716-725. (IF: 4. 579 )177. Sun, N., Wang, Y., Huang, J.C. & Chen, F.* (2008). Sugar-based growth, astaxanthin accumulation and carotenogenic transcription of heterotrophic Chlorella zofingiensis (Chlorophyta). Process Biochemistry, 43, 1288-1292. (IF: 3. 225 )176. Cheng, K.W., Wong, C.C., Cho, C.K., Chu, I.K., Sze, K.H., Lo, C., Chen, F. & Wang, M.F. (2008). Trapping of phenylacetaldehyde as a key mechanism responsible for naringenin’s inhibitory activity in mutagenic 2-amino-1-methyl-6-phenylimidazo [4,5-b]phyridine (PhIP) formation. Chemical Research in Toxicology, 21, 2026-2034. (IF: 3. 969 ) (IMARS Highlights, 2009, vol. 4, no. 1, p.17-18.)175. Li, Y.T., Huang, J.C., Sandmann, G. & Chen, F.* (2008). Glucose sensing and the mitochondrial alternative pathway are involved in the regulation of astaxanthin biosynthesis in the dark-grown Chlorella zofingiensis (Chlorophyceae). Planta, 228, 735-743. (IF: 3.4 20 )174. Ho, S.Y. & Chen, F.* (2008). Lipid characterization of Mortierella alpina grown at different NaCl concentrations. Journal of Agricultural and Food Chemistry, 56, 7903-7909. (IF: 3. 239 )173. Ma, J.Y., Peng, X.F., Cheng, K.W., Chen, B., Chen, F. & Wang, M.F. (2008). Use of capillary electrophoresis to evaluate protective effects of methylglyoxal scavengers on the activity of creatine kinase. Journal of Separation Science, 31, 2846-2851. (IF: 2. 725 )172. Peng, X.F., Ma, J.Y., Cheng, K.W., Chen, B., Chen, F. & Wang, M.F. (2008). High performance liquid chromatographic determination of creatine kinase activity influenced by methylglyoxal. Biomedical Chromatography, 23, 170-174. (IF: 1. 880 )171. Hu, Z.Y., Li, Y.T., Sommerfeld, M, Chen, F. & Hu, Q. (2008). Enhanced protection against oxidative stress in an astaxanthin overproduction Haematococcus mutant (Chlorophyceae). European Journal of Phycology, 43, 365-376. (IF: 2.193 )170. Ho, S.Y. & Chen, F.* (2008). Genetic characterization of Mortierella alpina by sequencing the 18S-28S ribosomal gene internal transcribed spacer region. Letters in Applied Microbiology, 47, 250-255. (IF: 1. 872 )169. Chen, G.Q., Jiang, Y. & Chen, F.* (2008). Salt-induced alterations in lipid composition of diatom Nitzshia laevis (Bacillariophyceae). Journal of Phycology, 44, 1309-1314. (IF: 2. 729 )168. Li, Y.Q., Zhang, X.W., Chen, G., Wei, D. & Chen, F. (2008). Algal lectins for prevention of HIV transmission. Current Medicinal Chemistry, 15, 1096-1104. (IF: 4.806 )167. Wong, C.C., Wang, Y., Cheng, K.W., Chiu, J.F., He, Q.Y. & Chen, F.* (2008). Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells. Journal of Proteome Research, 7, 2050-2058. (IF: 5. 413 )166. Peng, X.F., Cheng, K.W., Ma, J.Y., Chen, B., Ho, C.T., Chen, F. & Wang, M.F. (2008). Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. Journal of Agricultural and Food Chemistry, 56, 1907-1911. (IF: 3. 239 )165. Li, Y.T., Sommerfeld, M., Chen, F.* & Hu, Q. (2008). Consumption of oxygen by astaxanthin biosynthesis: A protective mechanism against oxidative stress in Haematococcus pluvialis (Chlorophyceae). Journal of Plant Physiology, 165, 1783-1797. (IF: 3.057 )164. Huang, J.C., Liu, J., Li, Y.T. & Chen, F.* (2008). Isolation and characterization of the phytoene desaturase gene as a potential selective marker for genetic engineering of the astaxanthin-producing green alga Chlorella zofingiensis (Chlorophyta). Journal of Phycology, 44, 684-690. (IF: 2. 729 )163. Chen, G.Q., Jiang, Y. & Chen, F.* (2008). Variation of lipid class composition in Nitzschia laevis as a response to growth temperature change. Food Chemistry, 109, 88-94. (IF: 4.268 )162. Zhang, X.W., Yap, Y., Wei, D., Chen, G. & Chen, F. (2008). Novel omics technologies in nutrition research. Biotechnology Advances, 26, 169-176. (IF: 10.959) 161. Peng, X.F., Zheng, Z.P., Cheng, K.W., Shan, F., Ren, G.X., Chen, F., Wang, M.F. (2008). Inhibitory effect of mung bean extract and its constituents vitexin and isovitexin on the formation of advanced glycation endproducts. Food Chemistry, 106, 475-481. (IF: 4.268 )160. Wong, C.C., Cheng, K.W., He, Q.Y. & Chen, F.* (2008). Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses. Proteomics Clinical Applications, 2, 338-354. (IF: 1. 916 )159. Fan, K.W., Fok, L., Lee, J.H.W. & Chen, F.* (2007). Epilithic diatom as a biological indicator for the assessment of water quality in the East River. Water Science & Technology: Water Supply, 7(2), 147-155. (IF: 1. 119 )158. Cheng, K.W., Wu, Q., Zheng, Z.P., Peng, X.F., Simon, J.E., Chen, F. & Wang, M.F. (2007). Inhibitory effect of fruit extracts on the formation of heterocyclic amines. Journal of Agricultural and Food Chemistry, 55, 10359-10365. (IF: 3. 239 ) 157. Cheng, K.W., Chen, F. & Wang, M.F. (2007). 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A systematic survey of antioxidant activity of 30 Chinese medicinal plants using the ferric reducing antioxidant power assay. Food Chemistry, 97, 705-711. (IF: 4.268 )138. Wang, S.B., Chen, F. *, Sommerfeld, M. & Hu, Q. (2005). Isolation and characterization of cell wall-deficient Haematococcus pluvialis mutants. Proteomics, 5, 4839-4851. [featured in the cover of the journal]. (IF: 4.615 )137. Zhang, X.W., Yap, Y.L., Wei, D., Chen, F. &Danchin, A. (2005). Molecular diagnosis of human cancer type by gene expression profiles and independent component analysis. European Journal of Human Genetic s, 13, 1303-1311. (IF: 3. 997 )136. He, H.Z., Li, H.B., Jiang, Y. & Chen, F. * (2005). Determination of paralytic shellfish poisoning toxins in cultured microalgae by high-performance liquid chromatography with fluorescence detection. Analytical and Bioanalytical Chemistry, 383, 1014-1017. (IF: 3. 733 )135. He, H.Z., Li, H.B. & Chen, F. * (2005). Determination of vitamin B in seawater and microalgal fermentation media by high-performance liquid chromatography with fluorescence detection. Analytical and Bioanalytical Chemistry, 383, 875-879. (IF: 3. 733 )134. Li, H.B. & Chen, F. * (2005). Preparative isolation and purification of phillyrin from the medicinal plant Forsythia suspensa by high-speed counter-current chromatography. Journal of Chromatography A, 1083, 102-105. (IF: 4.362 )133. Ip, P.F. & Chen, F. * (2005). Employment of reactive oxygen species to enhance astaxanthin formation in Chlorella zofingiensis in heterotrophic culture. Process Biochemistry, 40, 3491-3496. (IF: 3. 225 )132. Ip, P.F. & Chen, F. * (2005). Peroxynitrite and nitryl chloride enhance astaxanthin production by the green microalga Chlorella zofingiensis in heterotrophic culture. Process Biochemistry, 40, 3595-3599. (IF: 3. 225 )131. Li, H.B. & Chen, F. * (2005). Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. Journal of Chromatography A, 1074, 107-110. (IF: 3.908)130. Chen, F.*, Li, H.B., Wong, R.N.S., Ji, B. & Jiang, Y. (2005). Isolation and purification of the bioactive carotenoid zeaxanthin from the microalga Microcystis aeruginosa by high-speed counter-current chromatography. Journal of Chromatography A, 1064, 183-186. (IF: 4.362 )129. Li, H.B. & Chen, F. * (2005). Simultaneous separation and purification of five coumarins from the Chinese medicinal herb Cnidium monnieri by high-speed counter-current chromatography. Journal of Separation Science, 28, 268-272. (IF: 2. 725 )128. Ip, P.F. & Chen, F.* (2005). Production of astaxanthin by the green microalga Chlorella zofingiensis in the dark. Process Biochemistry, 40, 733-738. (IF: 3. 225 )127. Liu, X.J., Jiang, Y. & Chen, F.* (2005). 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A highly sensitive fluorimetric method for the determination of fluoride in biological material with Al -calcein complex. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 5, 501-504. (IF: 3.733)68. Li, H.B., Chen, F. * & Xu, X.R. (2000). A highly sensitive spectrophotometric method with solid phase extraction for the determination of methylmercury in human hair. Journal of Analytical Toxicology, 24(8), 704-707. (IF: 1.994)67. Li, H.B., Chen, F. * & Jiang, Y. (2000). Determination of vitamin B12 in multivitamin tablets and fermentation medium by high performance liquid chromatography with fluorescence detection, Journal of Chromatography A, 891(2), 243-247. (IF: 4.362)66. Jiang, Y. & Chen, F. * (2000). Effects of temperature and temperature shift on docosahexaenoic acid production by the marine microalga Crypthecodinium cohnii. Journal of the American Oil Chemists Society, 77, 613-617. (IF: 2.181)65. Jiang, Y. & Chen, F. * (2000). 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Fluorimetric determination of methylmercury as an ion-association complex with rhodamine B in the presence of iodide. Fresenius Journal of Analytical Chemistry (changed to Analytical and Bioanalytical Chemistry), 367(5), 499-501. (IF: 3.733)59. Wen, Z.Y., Teng, X.W. & Chen, F. * (2000). A novel perfusion system for hybridoma cell cultures by two step sequential sedimentation. Journal of Biotechnology, 79, 1-11. (IF: 3.288)58. Chen, H. & Chen, F. * (2000). Effects of yeast elicitor on the growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension culture. Process Biochemistry, 35, 837-840. (IF: 3.225)57. Zhang, X.W., Shi, X.M. & Chen, F. * (1999). A kinetic model for lutein production by the green microalga Chlorella protothecoides in heterotrophic culture. Journal of Industrial Microbiology & Biotechnology, 23(6), 503-507. (IF: 2.786)56. Chen, H. & Chen, F. * (2000). Effect of yeast elicitor on the secondary metabolism of Ti transformed Salvia miltiorrhiza cell suspension cultures. Plant Cell Reports, 19(7), 710-717. (IF: 2.743)55. Zhong, J.J., Chen, F. & Hu, W.W. (2000). High density cultivation of Panax notoginseng cells in stirred bioreactors for the production of ginseng biomass and ginseng saponin. Process Biochemistry, 35, 491-496. (IF: 3.225)54. Yuan, J.P. & Chen, F. * (2000). Purification of trans-astaxanthin from a high-yielding astaxanthin ester-producing strain of the microalga Haematococcus pluvialis. Food Chemistry, 68, 443-448. (IF: 4.268)53. Jiang, Y. & Chen, F. * (1999). Effects of salinity on cell growth and docosahexaenoic acid content of the heterotrophic marine microalga Crypthecodinium cohnii. Journal of Industrial Microbiology & Biotechnology, 23(6), 508-513. (IF: 2.786)52. Ren, G. & Chen, F. * (2000). Drying of steamed Asian ginseng ( Panax ginseng) roots by microwave-hot air combination. Pharmazie, 55(2), 124-128. (IF: 0.911)51. Ren, G., Zhang, X.W. & Chen, F. * (2000). Predicting colour kinetics during red Asian ginseng ( Panax ginseng) preparation. Pharmazie, 55(4), 300-302. (IF: 0.911)50. Chen, Q., Chen, F. & Li, Z.Y. (1999). Preparation and surfactant properties of amino acid based surfactants. Chinese Chemical Letters, 10(9), 789-792. (IF: 0.805)49. Zhang X.W., Chen, F. * & Johns, M.R. (1999). Kinetic models for heterotrophic growth of Chlamydomonas reinhardtii in batch and fed-batch cultures. Process Biochemistry, 35, 385-389. (IF: 3.225)48. Yuan, J.P. & Chen, F. * (1999). Isomerization of trans-astaxanthin in organic solvents. Journal of Agricultural & Food Chemistry, 47, 3656-3660. (IF: 3.239)47. Zhang, X.W., Gong, X.D. & Chen, F. * (1999). Dynamics and stability analysis of the growth and astaxanthin production system of Haematococcus pluvialis. Journal of Industrial Microbiology & Biotechnology, 23(2), 133-137. (IF: 2.786)46. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of rosmarinic acid and lithospermic acid B in Ti transformed Salvia miltiorrhiza cell suspension cultures. Process Biochemistry, 34, 777-784. (IF: 3.225)45. Jiang, Y., Chen, F. * & Liang, S.Z. (1999). Production potential of docosahexaenoic acid by the heterotrophic marine dinoflagellate Crypthecodinium cohnii. Process Biochemistry, 34, 633-637. (IF: 3.225)44. Chen, H. & Chen, F. * (1999). Effects of methyl jasmonate and salicylic acid on cell growth and cryptotanshinone formation in Ti transformed Salvia miltiorrhiza cell suspension cultures. Biotechnology Letters, 21(9), 803-807. (IF: 1.964)43. Zhang, Y.M. & Chen, F. * (1999). A simple method for efficient separation and purification of c-phycocyanin and allophycocyanin from Spirulina platensis. Biotechnology Techniques (changed to Biotechnology Letters), 13(9), 601-603. (IF: 1.964)42. Chen, H. & Chen, F. * (1999). Kinetics of cell growth and secondary metabolism of a high-tanshinone-producing line of the Ti transformed Salvia miltiorrhiza cells in suspension cultures. Biotechnology Letters, 21(8), 701-705. (IF: 1.964)41. Zhang, X.W., Gong, X.D. & Chen, F.* (1999). Kinetic models for astaxanthin production by high cell density mixotrophic culture of the microalga Haematococcus pluvialis. Journal of Industrial Microbiology Biotechnology, 23, 691-696. (IF: 2.786)40. Boussiba, S., Wang, B., Yuan, J.P., Zarka. A. & Chen, F.* (1999). Changes in pigment profile in the green alga Haematococcus pluvialis exposed to environmental stresses. Biotechnology Letters, 21, 601-604. (IF: 1.964)39. Zhang, X.W., Zhang, Y.M. & Chen, F.* (1999). Application of mathematical models to the determination optimal glucose concentration and light intensity for mixotrophic culture of Spirulina platensis. Process Biochemistry, 34(5), 477-481. (IF: 3.225)38. Shi, X.M., Liu, H.J., Zhang, X.W. & Chen, F.* (1999). Production of biomass and lutein by Chlorella protothecoides at various glucose concentrations in heterotrophic cultures. Process Biochemistry, 34(4), 341-347. (IF: 3.225)37. Ren, G. & Chen, F. * (1999). Simultaneous quantification of ginsenosides in American ginseng ( Panax quinquefolium) root powder by visible/near infrared reflectance spectroscopy. Journal of Agricultual & Food Chemistry, 47, 2771-2775. (IF: 3.051)36. Chen, H., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1999). Production of lithospermic acid B and rosmarinic acid in hairy root cultures of Salvia miltiorrhiza. Journal of Industrial Microbiology & Biotechnology, 22, 133-138. (IF: 2.786)35. Ren, G. & Chen, F. * (1999). Degradation of ginsenosides in American ginseng ( Panax quiquefolium) extracts during microwave and conventional heating. Journal of Agricultural & Food Chemistry, 47(4), 1501-1505. (IF: 3.239)34. Shi, X.M. & Chen, F. * (1999). Production and rapid extraction of lutein and the other lipid-soluable pigments from Chlorella protothecoides grown under heterotrophic and mixotrophic conditions. Nahrung/Food (changed to Molecular Nutrition and Food Research), 43(2), 109-113. (IF: 4.579)33. Yuan, J.P. & Chen, F. * (1999). Simultaneous separation and determination of sugars, ascorbic acid and furanic compounds by HPLC-dual detection. Food Chemistry, 64(3), 423-427. (IF: 4.268)32. Yuan, J.P. & Chen, F. * (1999). Hydrolysis kinetics of astaxanthin esters and stability of astaxanthin of Haematococcus pluvialis during saponification. Journal of Agricultural & Food Chemistry, 47(1), 31-35. (IF: 3.239)31. Zhang, X.W., Zhang, Y.M. & Chen, F.* (1998). Kinetic models for phycocyanin production by high cell density mixotrophic culture of the microalga Spirulina platensis. Journal of Industrial Microbiology & Biotechnology, 21(6), 283-388. (IF: 2.786)30. Yuan, J.P. & Chen, F. * (1998). Degradation of ascorbic acid in aqueous solution. Journal of Agricultural & Food Chemistry, 46(12), 5078-5082. (IF: 3.239)29. Vazhappilly, R. & Chen, F. * (1998). Heterotrophic production potential of omega-3 polyunsaturated fatty acids by microalgae and algae-like microorganisms. Botanica Marina, 41, 553-558. (IF: 1.628)28. Yuan, J.P. & Chen, F. * (1998). Chromatographic separation and purification of trans-astaxanthin from the extracts of Haematococcus pluvialis. Journal of Agricultural & Food Chemistry, 46(8), 3371-3375. (IF: 3.239)27. Li, X., Lin, W., Gao, P. & Chen, F. (1998). Endoglucanase S, a novel endocellulase exhibiting exoglucanase activity from a newly isolated Streptomyces sp. LX. Journal of Applied Microbiology, 85, 347-356. (IF: 2.658)26. Yuan, J.P., Chen, H. & Chen, F. * (1998). Simultaneous determination of rosmarinic acid, lithospermic acid B and related phenolics in Salvia miltiorrhiza by HPLC. Journal of Agricultural & Food Chemistry, 46(7), 2651-2654. (IF: 3.239)25. Li, X. & Chen, F. * (1998). Improvement in isolation of gliding bacteria by the elimination of soluable sugars. Biotechnology Techniques (changed to Biotechnology Letters), 12(5), 343-345. (IF: 1.964)24. Ren, G. & Chen, F. * (1998). Drying of American ginseng ( Panax quinquefolium) roots by microwave-hot air combination. Journal of Food Engineering, 35(4), 433-443. (IF: 2.845)23. Gong, X. & Chen, F. * (1998). Influence of medium components on astaxanthin content and production of Haematococcus pluvialis. Process Biochemistry, 33(4), 385-391. (IF: 3.225)22. Yuan, J.P. & Chen, F. * (1998). Separation and identification of furanic compounds in fruit juices and drinks by HPLC-PDA detection. Journal of Agricultural & Food Chemistry, 46, 1286-1291. (IF: 3.239)21. Vazhappilly, R. & Chen, F. * (1998). Eicosapentaenoic acid and docosahexaenoic acid production potential of microalgae and their heterotrophic growth. Journal of the American Oil Chemists Society, 75, 393-397. (IF: 2.181)20. Chen, H., Yuan, J.P., Chen, F. *, Zhang, Y.L. & Song, J.Y. (1997). Tanshinone production in Ti transformed Salvia miltiorrhiza cell suspension cultures. Journal of Biotechnology, 58(3), 147-156. (IF: 3.288)19. Chen, F. *, Chen, H. & Gong, X. (1997). Mixotrophic and heterotrophic growth of Haematococcus lacustris and rheological behaviour of the cell suspensions. Bioresource Technology, 62(1-2), 19-24. (IF: 5.352)18. Gong, X.D. & Chen, F. * (1997). Optimization of culture medium for growth of Haematococcus pluvialis. Journal of Applied Phycology, 9(5), 437-444. (IF: 2.239)17. Shi, X.M., Chen, F. *, Yuan, J.P. & Chen, H. (1997). Heterotrophic production of lutein by selected Chlorella strains. Journal of Applied Phycology, 9(5), 445-450. (IF: 2.239)16. Ren, G., Chen, F. *, Lian, H., Zhao, J. and Gao, X. (1997). Changes in hormone contents of Panax quinquefolium seeds during stratification. Journal of Horticultural Science (changed to Journal of Horticultural Science & Biotechnology) , 72(6), 901-906. (IF: 0.797)15. Gong, X.D. & Chen, F. * (1997). Rapid detection of heterotrophic growth of Haematococcus pluvialis using indirect conductimetry. Biotechnology Techniques (changed to Biotechnology Letters), 11(11), 841-844. (IF: 1.964)14. Ren, G. and Chen, F. * (1997). Determination of moisture content of ginseng by near infra-red reflectance spectroscopy. Food Chemistry, 60, 433-436. (IF: 4.268)13. Yuan, J.P. & Chen, F. * (1997). Identification of astaxanthin isomers in Haematococcus lacustris by HPLC-photodiode array detection. Biotechnology Techniques (changed to Biotechnology Letters), 11(7), 455-459. (IF: 1.964)12. Yuan, J.P., Gong, X.D. & Chen, F. * (1997). Separation and analysis of carotenoids and chlorophylls in Haematococcus lacustris by high-performance liquid chromatography photodiode array detection. Journal of Agricultural & Food Chemistry, 45(5), 1952-1956. (IF: 3.239)11. Chen, F. * & Zhang, Y. (1997). High cell density mixotrophic culture of Spirulina platensis on glucose for phycocyanin production using a fed-batch system. Enzyme and Microbial Technology, 20, 221-224. (IF: 3.040)10. Shi, X.M. and Chen, F. * (1997). Stability of lutein under various storage conditions. Nahrung/Food (changed to Molecular Nutrition and Food Research), 41(1), 38-41. (IF: 4.579)9. Chen, F.* (1996). High cell density culture of microalgae in heterotrophic growth. Trends in Biotechnology, 14(11), 421-426 [featured in the cover of the journal; the article was also cited by a landmark article in Science (292: 2073-2075, 2001) as one of the major reasons they initiated the study]. (IF: 9.487)8. Chen, F. *, Zhang, Y. & Guo, S. (1996). Growth and phycocyanin formation of Spirulina platensis in photoheterotrophic culture. Biotechnology Letters, 18(5), 603-608. (IF: 1.964)7. Chen, F. * & Johns, M.R. (1996). Heterotrophic growth of Chlamydomonas reinhardtii on acetate in chemostat culture. Process Biochemistry, 31(6), 601-604. (IF: 3.225)6. Chen, F. & Johns, M.R. (1996). High cell density culture of Chlamydomonas reinhardtii on acetate using fed-batch and hollow-fibre cell-recycle systems. Bioresource Technology, 55(2), 103-110. (IF: 5.352)5. Chen, F. * & Johns, M.R. (1996). Relationship between substrate inhibition and maintenance energy of Chlamydomonas reinhardtii in heterotrophic culture. Journal of Applied Phycology, 8(1), 15-19. (IF: 2.239)4. Yuan, J.P., Gong X.-D. & Chen, F. * (1996). Separation and identification of astaxanthin esters and chlorophylls in Haematococcus lacustris by HPLC. Biotechnology Techniques (changed to Biotechnology Letters), 10(9), 655-660. (IF: 1.964)3. Chen, F. *& Johns, M.R. (1995). A strategy for high cell density culture of heterotrophic microalgae with inhibitory substrates. Journal of Applied Phycology, 7, 43-46. (IF: 2.239)2. Chen, F. * & Johns, M.R. (1994). Substrate inhibition of Chlamydomonas reinhardtii by acetate in heterotrophic culture. Process Biochemistry, 29, 245-252. (IF: 3.225)1. Chen, F.* & Johns, M.R. (1991). Effect of C/N ratio and aeration on the fatty acid composition of heterotrophic Chlorella sorokiniana. Journal of Applied Phycology, 3, 203-209. (IF: 2.239)