簡介
孫汭教授，1982畢業於山西醫科大學（77級，本科），2000年獲白求恩醫科大學碩士學位（在職）。曾就職於山東省醫學科學院基礎醫學研究所，任“山東省腫瘤免疫與醫學基因工程重點實驗室”常務副主任，1998年聘為研究員。1995.8--1996.8和 2001.3--2006.3先後在美國國立衛生研究院(NIH)癌症研究所（NCI）和酒精性疾病研究所（NIAAA）進行天然免疫學的合作研究。為主承擔和完成了科研項目30餘項。獲得省部級科技進步獎6項。在中文核心期刊發表學術論文100餘篇。發表SCI英文論文50餘篇，其中在SCI英文論文中首位/通訊作者10餘篇。1994年獲第四屆“中國青年科技獎”，1998年享受國務院政府特殊津貼，2005年獲美國國立衛生研究院（NIH）傑出研究人員獎。研究方向
1. 肝臟的天然免疫耐受機理及其肝臟的免疫病理學研究；2. 肝臟NK細胞對肝臟再生與損傷的負調機理；
3. 天然免疫受體“泛特異識別的結構生物學基礎；
4．NK細胞功能相關基因工程蛋白質藥物的研發
代表性論文
1. Sun R, Wei HM, Zhang jh, et al. Recombinant human prolactin improves antitumor effects of murine natural killer cells in vitro and in vivo. Neuroimmunomodulation; 2002; 10: 169-176.2. Welniak LA, Sun R, Murphy WJ. The role of growth hormone in T-cell development and reconstitution. J Leukocyte Biol; 2002; 71: 381-387.
3. Sun R, Gault RA, Welniak LA, Tian ZG, Richards S and Murphy WJ. Immunologic and hematopoietic effects of recombinant human prolactin after syngeneic bone marrow transplantation in mice. Biol Blood Marrow Transplant. 2003 Jul;9(7):426-434.
4. Sun R, Fan J, Wei HM, et al. Use of interleukin-15 for preparation of adherent NK cells from human peripheral blood: comparison with interleukin-2. J Immunol Methods. 2003;279: 79-90.
5. Sun R, Wei HM, Zhang JH, et al. The effects of natural killer-cell depletion on ex vivo expansion of hematopoietic progenitor cells from umbilical cord blood. Haematologica. 2003;88 : 561-569.
6. Sun R, Gao B. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology. 2004 Nov;127(5):1525-39.
7. Sun R, Tian Z, Kulkarni S, Gao B. IL-6 prevents T cell-mediated hepatitis via inhibition of NKT cells in CD4+ T cell- and STAT3-dependent manners. J Immunol. 2004 May 1;172(9):5648-55.
8. Sun R, Li AL, Wei HM, et al. Expression of prolactin receptor and response to prolactin stimulation of human NK cell lines. Cell Res. 2004;14: 67-73
9. Radaeva S, Sun R, Pan HN, et al. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology., 2004; 39: 1332-1342
10. Sun R, Jaruga B, Kulkarni S, Sun HY and Gao B. IL-6modulates hepatocyte proliferation via inducytion of HCF/p21cip1: Regulation by SOCS3. Biochemical and Biophysical Research Communication. 2005; 338: 1943-1949
11. Sun R, Park O, Horiguchi N, Kulkarni S, Jeong W-IL, Sun HY, Radaeva S and Gao B. STAT1 contributes to dsRNA inhibition if liver regeneration after partial hepatectomy in mice. Hepatology. 2006; 44: 955-966.
12. Radaeva S, Sun S, Jaruga B, Nguyen VT, Tian Z, Gao B. Natural Killer Cells Ameliorate Liver fibrosis by Killing Activated Stellate Cells in NKG2D- dependent and tumour necrosis factor-related apoptosis-inducing ligand-dependent manners. Ganstroenterology. 2006; 130: 435-452
13. Pan H, Sun R(co-first),, Jaruga B, Hong F, Kim WH, Gao B. Chronic Ethanol Consumption Inhibits Hepatic Natural Cytomegalovirus-Induced Hepatitis. Alcohol Clin Exp Res; 2006;30:1615-1623
