鄭文杰[暨南大學生命技術學院教授]

鄭文杰[暨南大學生命技術學院教授]

暨南大學生命技術學院教授,主要從事無機化學、配位化學、生物無機化學、微量元素的化學與生物化學的教學科研工作。在無機化學專業招收培養碩士研究生,在水生生物學、生化與分子生物學專業招收培養博士研究生。在硒雜環化合物、硒的生物有機化等領域主持並完成了多項省部級科研項目,包括國家自然科學基金和省、教育部多項基金;獲廳局級獎項兩項(廣東省高教廳科技進步獎,廣東省教育廳自然科學獎);獲國務院僑辦所屬高校優秀教師稱號。在國內外各類學術期刊上發表重要研究論文90餘篇(多篇被SCI和EI收錄)。在納米硒及其製備與保存和抗腫瘤藥物先導化合物方面申請專利5項。

基本信息

人物經歷

碩士研究生畢業(中山大學,1985.07)後到暨南大學化學系工作,曾在香港大學進修學習(1989.12~1990.6);在職攻讀博士學位(中山大學生物無機化學專業1994.09~1998.09)和博士後在站工作(華南師範大學生物學, 1999.09~2002.12);先後擔任廣東省連南瑤族自治縣科技副縣長(1990.09~1992.08),暨南大學化學系副主任(1994.01~1996.11),暨南大學生命科技學技術學院黨政工作(2003.09~2006.07書記兼副院長,2006.07~2007.01書記兼院長),先後兩次主持暨南大學研究生部工作(1996.12~2003.07, 2007.01~至今)。

主要社會兼職:廣東省學位與研究生學會副理事長兼秘書長(2000.05~2003.10),廣東化工學會副理事長(2004.05~),廣東省遺傳學常務理事(2003.07~),廣東省教育學會常務理事(2001.05~)等。

主講課程

生物無機化學、配位化學及高等無機化學等;指導碩士、博士及博士後多名,畢業的研究生中,曾獲南粵優秀研究生、暨南大學優秀碩士畢業生等獎勵。

主要貢獻

著作論文

主要著作:

(1) 鄭文杰,歐陽政.植物有機硒的化學及其醫學套用.暨南大學出版社,2001,7.

(2) 歐陽政,蔡端仁,鄭文杰.生物體中硒的有機形態的分析研究.分析化學新進展,科學出版社(ISBN-7-03-010946-5),2002.11,510-516.

主要論文:

*為通訊作者

1 Li Y, Li X, Wong YS, Chen Tianfeng, Zhang H, Liu C, Wenjie Zheng*. (2011) The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosis. Biomaterials, 32, 9068-9076.

2 Fang Yang, Quanming Tang, Xueyun Zhong, Yan Bai, Tianfeng Chen, Yibo Zhang,Yinghua Li, Wenjie Zheng*. (2012) Surface decoration by Spirulina polysaccharide enhances the cellular uptake and anticancer efficacy of selenium nanoparticles. International Journal of Nanomedicine. In press.

3 Zhang H, Chen Tianfeng, Jiang J, Wong YS, Yang F, Wenjie Zheng*. Selenium-containing allophycocyanin purified from selenium-enrich Spirulina platensis protects human erythrocytes from AAPH-induced oxidative damage through inhibition of ROS generation. Journal of Agricultural and Food Chemistry, 2011, 59, 8683-8690.

4 Linlin Li, Yum-Shing Wong, Tianfeng Chen, Cundong Fana and Wenjie Zheng*. (2011) Ruthenium Complexes Containing Bis-benzimidazole Derivatives as a New Class of Apoptosis Inducers. Dalton Transactions. DOI: 10.1039/C1DT11950H.

5 Ya-Nan Liu, Tianfeng Chen, Wen-Jie Mei, Xiao-Mei Huang, Shuo Wu, Yum-Shing Wong, Jie Liu*, Wenjie Zheng*. (2010) DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3’)TPP - Ru(phen)2Cl]Cl and its heterometallic derivatives. Chemico-Biological Interactions. 183, 349-356.

6 Chen Tianfeng, Yanan Liu, Wenjie Zheng, Jie Liu, Yum-Shing Wong. 2010. Ruthenium polypyridyl complexes target mitochondria and induce cancer cell apoptosis. Inorganic Chemistry. 49, 6366-6368.

7 Chen Tianfeng, Yum-Shing Wong*, Wenjie Zheng*, Jie Liu. (2009) Caspase- and p53-dependent apoptosis in breast carcinoma cells induced by a synthetic selenadiazole derivative. Chemico-Biological Interactions. 180, 54-60.

8 Chen Tianfeng, Wenjie Zheng*, Wong Yum-Shing, Yan Fang. (2008) Mitochondria-mediated apoptosis in human breast carcinoma MCF-7 cells induced by a novel selenadiazole derivative. Biomedicine & Pharmacotherapy. 62, 77-84.

9 Chen Tianfeng, Yum-Shing Wong*, Wenjie Zheng*, Yan Bai, Liang Huang. (2008) Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells. Colloids and Surfaces B: Biointerfaces 67, 26-31.

10 Chen Tianfeng, Wenjie Zheng*, Yang Fang,Bai Yan, Yum-Shing Wong. (2006) Accumulation of selenium in mixotrophic culture of Spirulina platensis on glucose. Bioresource Technology. 97, 2260-2265.

11 Qian Li, Tianfeng Chen*, Fang Yang, Jie Liu, Wenjie Zheng* (2010). Facile and controllable one-step fabrication of selenium nanoparticles assisted by L-cysteine. Materials Letters. 64, 614-617.

12 Chen Tianfeng, Wong Yum-Shing*, Wenjie Zheng* (2006) Purification and characterization of selenium- containing phycocyanin from selenium-enriched Spirulina platensis. Phytochemistry. 67, 2424-2430.

13 Chen TianFeng, Wong Yum-Shing*, Wenjie Zheng* (2010) Induction of G1 Cell Cycle Arrest and Mitochondria-Mediated Apoptosis in MCF-7 Human Breast Carcinoma Cells by Selenium-Enriched Spirulina Extract, Biomedicine & Pharmacotherapy. In press.

14 Chen Tianfeng, Wenjie Zheng*, Fang Yang, Yan Bai, Wong Yum-Shing*. (2006) Mixotrophic culture of high selenium-enriched Spirulina platensis on acetate and the enhanced production of photosynthetic pigments. Enzyme and Microbial Technology. 39, 103-107.

15 Chen TianFeng, Wenjie Zheng*, Wong Yum-Shing. (2008) Selenium-induced changes in activities of antioxidant enzymes and content of photosynthetic pigments in Spirulina platensis. Journal of Integrative Plant Biology. 50, 40-48.

16 Ya-Nan Liu, Shuo Shi, Wen-Jie Mei, Cai-Ping Tan, Lan-Mei Chen, Jie Liu*, Wenjie Zheng* Liang-Nian Ji. In vitro and in vivo investigations on the antiviral activity of a series of mixed-valence rare earth borotungstate heteropoly blues. European Journal of Medicinal Chemistry. 2008, 1963-1970.

17 Chen Tianfeng, Wen-Jie Mei, Yum-Shing Wong, Jie Liu, Yanan Liu, Huang-Song Xie and Wen-Jie Zheng. (2010) Chiral ruthenium polypyridyl complexes as mitochondria-targeted apoptosis inducers. Medicinal Chemistry Communications. 1, 73-75.

18 Yi Luo, Xiaoling Li, Yum-Shing Wong, Tianfeng Chen, Yibo Zhang, Wenjie Zheng*. 1,4-diselenophene-1,4-diketone induces caspase-dependent apoptosis in human A375 melanoma cells with involvement of mitochondrial dysfunction. Chem. Pharm. Bull., 2011, 59 (10), 1227-1232.

承擔課題

1 國家自然科學基金:含硒、碲藻藍蛋白的形態分析、抗腫瘤作用及機理研究 (20771044);

2 國家自然科學基金:新型有機硒化合物協同TRAIL誘導腫瘤細胞凋亡的分子機制研究 (21071062);

3 國家自然科學基金:硒雜環化合物及其自組裝膜的研究(20271022);

4 教育部博士點基金博導類項目:p53靶向性的含硒釕配合物及其抗腫瘤作用機理研究(20114401110004);

5 廣東省自然科學基金項目:硒代胱氨酸及其衍生物作為TRAIL增敏劑的分子機制研究(10251063201000002);

6 廣東省科技攻關項目:硒芳香環化合物作為臨床抗腫瘤化療藥物增敏劑的研製與開發(2008A030201020);

7 廣東省自然科學基金重點項目:螺旋藻轉化的含硒、碲藻膽蛋白及其抗氧化活性研究;

8 廣州市科技項目:無機硒在螺旋藻中的生物有機化和生物礦化(2001-J-010-01);

9 廣東省自然科學基金團隊項目子課題:微量元素硒納米化及其對海藻多糖生物活性的增強作用研究(039213);

10 廣東省自然科學基金:含硒小分子有序分子膜與過氧化物電化學測定方法研究,(010369);

11 教育部重點項目:新型富硒螺旋藻的硒形態與抗衰老活性研究(01141).

發明專利

(1) 鄭文杰, 王自, 白燕等. 液相胺基酸偶合的納米單質硒及其製備和保存方法。(專利申請號:2007100270458)

(2) 鄭文杰,陳填烽,張俊苓,楊芳.具抗腫瘤活性的硒氮芳香雜環化合物及其製備方法與套用(200610132475.1)

(3) 白燕,王玉東,鄭文杰,周艷暉.生物高聚物納米硒複合膜的製備方法(200610124279.X)

(4) 鄭文杰,王自,白燕 ,張俊苓,楊芳,周艷暉.液相維生素C複合的納米單質硒及其製備與保存方法(專利申請號:200610132382.9)

(5) 鄭文杰,楊芳,黃峙.活性蛋白複合型納米硒的製備及液相保存技術(專利申請號:200510086601.x)

(6) 白燕,鄭文杰,李維嘉等, 液相多、聚糖納米硒及其製備與保存(專利申請號:200510086602.4)

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