帥心濤

帥心濤

帥心濤,化學與化工學院教授,中山醫學院雙聘教授,中山醫學院生物醫學工程中心負責人,光電及功能複合材料研究院“納米生物技術”平台PI。以納米醫學技術為平台的腫瘤診斷及治療研究,主要涉及腫瘤顯像納米探針、抗癌藥物和核酸(例如:基因及RNAi等)的高效靶向傳輸等。

基本信息

工作經歷

2005年6月開始:中山大學化學與化工學院高分子所教授。

2003年6月-2005年5月:美國凱斯西儲大學研究員(研究助教授級)。

2002年1月-2003年5月:德國馬爾堡大學洪堡學者。

2001年1月-2001年12月:美國北卡州立大學訪問學者。

2000年10月-2000年12月:中國科學院工程塑膠國家工程研究中心,任研究三室主任。

1998年2月-2000年9月:中國科學院化學研究所,任副研究員及研究組長。其間赴日本名古屋大學及東京工業大學做訪問研究一年。

1996年10月-1997年12月:波蘭科學院聚合物化學研究所博士後。

教育背景

1993年3月-1996年10月:北京理工大學化工與材料學院學習,獲博士學位。

1986年9月-1993年2月:北京理工大學化工與材料學院學習,獲學士及碩士學位。

學術積累

一直從事新型生物降解及生物相容聚合物的合成及套用研究,近年來主要從事聚合物納米醫用材料的研究,在抗癌藥物和核酸的傳輸以及腫瘤顯像等方面取得一系列研究成果。

在包括《Macromolecules》、《Bioconjugate Chem.》、《Biomacromolecules》、《Chem. Mater.》、《Angew. Chem.》、《Chem. Commun.》、《Adv. Mater.》、《J. Controlled Release》、《Biomaterials》、《J. Biomed. Mater. Res.》等學術刊物上發表論文40多篇(其中,SCI收錄論文35篇),被國內外同行在SCI刊物上引用100多篇次(扣除自引)。

現為J. Controlled Release等7個國際學術期刊的審稿人。與歐、美、日等國家高水平研究室建立了穩固的學術聯繫,為開展高水平的國際合作奠定了堅實的基礎。

近5年來,作為負責人承擔2項納米醫學研究領域的國家自然科學基金項目。目前除了一項國家自然科學基金項目在研外,還承擔一項中山大學高層次引進人才基金項目。

主要論著

近5年來主要論著(SCI影響因子4以上的論文):

1.D. Cheng,G. Hong,W. Wang,R. Yuan,H. Ai,J. Shen *,B. Liang,J. Gao, X. Shuai*,“Nonclustered magnetite nanoparticle encapsulated biodegradable polymeric micelles with enhanced properties for in vivo tumor imaging”, J. Mater. Chem.,DOI:10.1039/C0JM03783D.(IF=4.795)

2.N. Cao,D. Cheng,S. Zou,H. Ai,J. Gao, X. Shuai*,“The synergistic effect of hierarchical assemblies of siRNA and chemotherapeutic drugs co-delivered into hepatic cancer cells”, Biomaterials,Doi:10.1016/j.biomaterials.2010.11.061.(IF=7.365)

3. J. Dai,S. Zou,Y. Pei,D. Cheng,H. Ai, X. Shuai*,“Polyethylenimine-grafted Copolymer of Poly(L-lysine) and Poly(ethylene glycol) for Gene Delivery”, Biomaterials,Doi:10.1016/j.biomaterials.2010.10.044.(IF=7.365)

4. G. Liu,Z. Wang,J. Lu,C. Xia,F. Gao,Q. Gong,B. Song,X. Zhao, X. Shuai,X. Chen,H. Ai,Z. Gu,“Low molecular weight alkyl-polycation wrapped magnetite nanoparticle clusters as MRI probes for stem cell labeling and in vivo imaging”, Biomaterials,2011,2,528-537. (IF=7.365)

5. W. Zhang,Y. Li,L. Liu *,Q. Sun, X. Shuai*,W. Zhu,Y Chen *,“Amphiphilic Toothbrushlike Copolymers Based on Poly(ethylene glycol) and Poly(ε-caprolactone) as Drug Carriers with Enhanced Properties”, Biomacromolecules, 2010,11 ,1331-1338.(IF=4.502)

6. B. Liang,M. He,C. Chan,Y. Chen,X. Li,Y. Li,D. Zheng,M. Lin,H. Kung, X. Shuai *,Ying Peng*,“The Use of Folate-PEG-grafted-hybranched-PEI Nonviral Vector for the Inhibition of Glioma Growth In The Rat”, Biomaterials 2009,30,4014-4020.(IF=7.365)

7. J. Lu,S. Ma,J. Sun,C. Xia,C. Liu,Z. Wang,X. Zhao,F. Gao,Q. Gong,B. Song, X. Shuai,Hua Ai,Zhongwei Gu,“Manganese ferrite nanoparticle micellar nanocomposites as MRI contrast agent for liver imaging”, Biomaterials 2009,30,2919-2928.(IF=7.365)

8. G. Chen*,W. Chen,Z. Wu,R. Yuan,Hua Li,J. Gao,X. Shuai*,“MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression”,Biomaterials 2009,30,1962-1970.(IF=7.365)

9. H. Ai,C. Flask,B. Weinberg, X. Shuai,M. D. Pagel,D. Farrell,J. Duerk,J. Gao,“Magnetite-loaded polymeric micelles as novel magnetic resonance probe”, Adv. Mater. 2005,17,1949-1952.(IF=8.379)

10. S. Mao, X. Shuai,F. Unger,and T. Kissel,“Synthesis and characterization of water-soluble poly (ethylene glycol)-graft-trimethyl chitosan block copolymers and their application as insulin delivery carriers”, Biomaterials 2005,26,6343-6356.(IF=7.365)

11. X. Shuai,T. Merdan,F. Unger,T. Kissel,“Biodegradable Supra-molecular Vehicle Showing Combined Good Biocompatibility and High Gene Transfection Efficiency”, Bioconjugate Chem. 2005,16,322-329.(IF=4.35)

12. N. Nasongkla†,X. Shuai†,H. Ai,J. Gao,“cRGD-functionalized micelle (cRGD-PEG-PCL) for targeted doxorubicin delivery to tumor neovasculature”,Angew. Chem. Int. Edi. 2004,43,6323-6327.(共同第1,IF=11.829)

13. Y. Zhao, X. Shuai,C. Chen,F. Xi,“Synthesis of star block copolymers from dendrimer initiators by combing ring-opening polymerization and atom transfer radical polymerization”, Macromolecules 2004,37,8854-8862.(IF=4.539)

14. X. Shuai,H. Ai,N. Nasongkla,S. Kim,and J. Gao,“Micellar Carriers Based on Block Copolymers of Poly(e-caprolactone) and Poly(ethylene glycol) for Doxorubicin Delivery”, J. Controlled Release 2004,98,415-426.(IF=5.949)

15. X. Shuai,T. Merdan,and T. Kissel,“Core-crosslinked Polymeric Micelles as Paclitaxel carriers”, Bioconjugate Chem. 2004,15,441-448.(IF=4.35)

16. Y. Zhao, X. Shuai,C. Chen,F. Xi,“Synthesis of novel dendrimer-like star block copolymers with definite number of arms by combination of ROP and ATRP”, Chem. Commun. 2004,14,1608-1609.(IF=5.504)

17. X. Shuai,T. Merdan,F. Unger,W. Matthias,and T. Kissel,“Novel Biodegradable Ternary Copolymers hy-PEI-g-PCL-b-PEG: Synthesis,Characterization and Potential as Efficient Non-viral Gene Delivery Vectors”, Macromolecules 2003,36,5751-5759.(IF=4.539)

18. Y. Zhao, X. Shuai,C. Chen,F. Xi,“Synthesis and Characterization of Star-Shaped Poly(L-lactide)s Initiated with Hydroxyl-Terminated Poly(Amidoamine) (PAMAM-OH) Dendrimers”, Chem. Mater. 2003,15,2836-2843.(IF=5.368)

19. M. Wei, X. Shuai, A. E. Tonelli,“Melting and Crystallizatioin Behavior of Biodegradable Polymers Enzymatically Coalesced from Their Cyclodextrin Inclusion Complexes”, Biomacromolecules 2003,4,783-792.(IF=4.502)

20. X . Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Stereo-selectivity in the Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins”, Macromolecules 2002,35,3778-3780.(IF=4.539)

21. Y. Na,Y. He, X. Shuai,Y. Kikkawa,Y. Doi,and Y. Inoue,“Compatibilization Effect of Poly(e-caprolactone)- b-Poly(ethylene glycol) Block Copolymers and Phase Morphology Analysis in Immiscible Poly(lactide)/ Poly(e-caprolactone) Blends”, Biomacromolecules 2002,3,1179-1186.(IF=4.502)

22. X. Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Formation of Inclusion Complexes of Poly(3-hydroxybutyrate)s with Cyclodextrins 1: Immobilization of Atactic Poly(R,S-3-hydroxybutyrate) and Miscibility Enhancement between Poly(R,S-3-hydroxy butyrate) and Poly(e-caprolactone)”, Macromolecules 2002,35,3126-3132.(IF=4.539)

23. X. Shuai,F. Porbeni,M. Wei,T. Bullions,A. E. Tonelli,“Inclusion Complex Formation between α,γ-Cyclodextrins and a Triblock Copolymer and the Cyclodextrin Type-Dependent Microphase Structures of their Coalesced Samples”, Macromolecules 2002,35,2401-2405. (IF=4.539)

24. X. Shuai,M. Wei,F. Porbeni,A. E. Tonelli,“Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin2: A novel means to modify the biodegradation behavor of biodegradable block copolymers”, Biomacromolecules 2002,3,201-207.(IF=4.502)

25. X. Shuai,F. Porbeni,M. Wei,I. Shin & A. E. Tonelli,“Formation of and coalescence from the inclusion complex of a biodegradable block copolymer and a-cyclodextrin: A novel means to modify the phase structure of biodegradable block copolymers”, Macromolecules 2001,34,7355-7361.(IF=4.539)

26. Y. He,J. Li, X. Shuai,Y. Inoue,“Reversible thinning/thickening phenomenon of polymer blends in aqueous media”, Ma cromolecules 2001,34,8166-8172.(IF=4.539)

27. Y. He, X. Shuai,A. Cao,K. Kasuya,Y. Doi,Y. Inoue,“Enzymatic biodegradation of synthetic atactic P(R,S-hydroxybutyrate) induced by amorphous polymer and the enzymatic degradation temperature window of amorphous systems”, Biomacromolecules 2001,2,1045-1051.(IF=4.502)

28. Y. He,He, X. Shuai,A. Cao,K. Kasuya,Y. Doi,Y. Inoue,"Enzymatic biodegradation of chemosynthetic atactic P(3HB) enhanced by an amorphous non-biodegradable polymer: blend of atactic P(3HB) with PMMA", Macromol. Rapid Comm., 2000,21: 1277-1281.(IF= 4.146)

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