c-kit受體

other certain testin

CD117, also called KIT or C-kit receptor, is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types. This receptor binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer.[1]
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
c-kit的配體為幹細胞生長因子.c-kit受體正常表達於造血乾/祖細胞,在急性淋巴細胞白血病中極少或不表達,而在急性髓性白血病(AML)中則表達較高,但在AML的各亞型表達不盡一致,因而c-kit受體檢測有助於急性白血病(AL)的分類診斷和分型診斷.c-kit在原發性AML患者的表達高於MDS轉變的AML,因此,c-kit檢測有助於兩種不同AML的鑑別診斷.SCF/c-kit誘導的細胞凋亡耐受與AML患者化療療效差有關,抗c-kit單抗可逆轉AL細胞對化療的凋亡耐受,這為難治性AML的治療提供了新的思路.