阿扎他定英文名稱：Azatadine
中文別名：氮他定、哌吡庚啶
英文別名：Indulian、Lergocil、Zadin
【藥理】
作用類似賽庚啶。具有抗組胺、抗膽鹼、抗 5-HT及鎮靜作用。【適應症】
用於各種過敏性疾病。【用法用量】
口服：1mg/次， 1日 2次。12歲兒童， 0.5—1mg/次， 1日 2次。片劑： 1mg；糖漿劑：0.5mg(5ml)。
【禁用慎用】
青光眼、前列腺肥大者慎用。【不良反應】
主要為睏倦和上腹部不適。通用名稱：阿扎他定
英文名稱：Azatadine
中文別名：氮他定、哌吡庚啶
英文別名：Indulian、Lergocil、Zadin
【適應症】
1.Azatadine is an antihistamine. Azatadine blocks the effects of the naturally occurring chemical histamine in your body.
2.Azatadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.
3.Azatadine may also be used for purposes other than those listed in this medication guide.
【用法用量】
1.Take azatadine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
2.Take each dose with a full glass of water.
3.Azatadine can be taken with or without food.
4.Never take more of this medication than is prescribed for you. The maximum amount of azatadine that you should take in 1 day is 2 mg.
5.Store azatadine at room temperature away from moisture and heat.
【注意事項】
1.Use caution when driving, operating machinery, or performing other hazardous activities. Azatadine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
2.Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking azatadine.
If Miss a Dose: 1.Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.
Contraindications: 1.Do not take azatadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.
2.Before taking this medication, tell your doctor if you have
*glaucoma or increased pressure in the eye;
*a stomach ulcer;
*an enlarged prostate, bladder problems or difficulty urinating;
*an overactive thyroid (hyperthyroidism);
*hypertension or any type of heart problems; or
*asthma.
3.You may not be able to take azatadine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.
4.Azatadine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take azatadine without first talking to your doctor if you are pregnant.
5.Azatadine passes into breast milk. Infants are especially sensitive to the effects of antihistamines, and serious side effects could occur in a nursing baby. Azatadine is not recommended if you are breast-feeding a baby. Do not take azatadine without first talking to your doctor if you are nursing a baby.
6.If you are over 60 years of age, you may be more likely to experience side effects from azatadine. You may require a lower dose of this medication.
Special Concerns: 1.Use caution when driving, operating machinery, or performing other hazardous activities. Azatadine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.
2.Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking azatadine.
【不良反應】
1.Stop taking azatadine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).
2.Other, less serious side effects may be more likely to occur. Continue to take azatadine and talk to your doctor if you experience
*sleepiness, fatigue, or dizziness;
*headache;
*dry mouth; or
*difficulty urinating or an enlarged prostate.
3.Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.
【相互作用】
1.Do not take azatadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.
2.Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These may contain medicines similar to azatadine, which could lead to an overdose of antihistamine.
3.Before taking this medication, tell your doctor if you are taking any of the following medicines:
*anxiety or sleep medicines such as Alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion);
*medications for depression such as Amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); or
*any other medications that make you feel drowsy, sleepy, or relaxed.
4.Drugs other than those listed here may also interact with azatadine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
【藥物過量】
1.Seek emergency medical attention.
2.Symptoms of an azatadine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures.
