錢旭紅

錢旭紅

錢旭紅,男,1962年生於江蘇寶應,長江學者、博導、教授、”973”首席科學家、中國工程院院士、國家自然科學基金化學部諮詢委員、英國皇家化學會會士、德國洪堡基金會學術大使。現任華東師範大學校長、黨委委員、常委、黨委副書記。

基本信息

人物履歷

錢旭紅錢旭紅
1978年09月——1982年07月,華東化工學院(現華東理工大學)石油化工系學習,獲學士學位;

1982年09月——1985年04月,華東化工學院(現華東理工大學)精細化工系學習,獲碩士學位;

1988年07月,獲華東理工大學工學博士學位;

1989年08月——1990年08月,受美國Welch基金會資助,到美國德克薩斯州拉瑪大學ResearchAssociate,從事博士後研究,期間他從事了昆蟲生長調節劑的研究工作;

1990年09月——1991年12月,德國巴伐利亞州維爾茲堡大學洪堡基金(AvH)博士後,從事DNA嵌入劑、切斷荊的研究;

1988年——1992年04月,華東理工大學講師

1986年——1987年,華東理工大學精細化工系黨總支副書記;

1992年08月——1995年04月,先後任華東理工大學精細化工學科主任、藥物化工研究所所長;

1995年05月——1995年07月,國家高級教育行政學院學員;

1995年09月——1996年02月,華東理工大學校長助理;

1996年03月——2000年10月,華東理工大學副校長;

2000年09月——2004年06月,大連理工大學教育部長江學者獎勵計畫特聘教授

2002年01月——2010年01月,上海市化學生物學重點實驗室主任(兼);

2003年03月——2006年,國家南方農藥創製中心(上海)主任(兼);

2004年07月——2015年03月,華東理工大學校長;

2007年04月,中國化工學會副理事長;

2007年——2008年,亞洲及太平洋化工聯盟主席;

2011年12月,當選中國工程院院士(化工、冶金與材料工程學部);

2018年1月——至今,華東師範大學校長、黨委委員、常委、黨委副書記。

研究方向

錢旭紅華東師大 現任校長 錢旭紅 院士
錢旭紅主要研究方向,包括:是生物有機化學,化學生物技術與工程,其研究工作主要體現在用作農藥先導、螢光感測器、抗癌先導、人工核酸酶、細胞激活劑的芳香雜環分子設計、合成、構效關係及生物套用。具體研究方向:

研究方向1.染料的化學生物學

其研究主要體現在螢光感測器與抗癌先導,包括以下內容:

螢光感測器:由萘,萘醯亞胺,香豆素,氟硼吡咯,聚合物衍生的高選擇性汞離子銅離子鋅離子銀離子螢光感測器,某些陰離子螢光感測器,以及其它的螢光探針,螢光標記。

抗癌先導:由硫化合物,噻類芳香雜環,羰醯亞胺,萘醯亞胺,萘內醯胺、苯並吲哚酚嗪,吖啶,苊萘醌,苊萘吡咯羰腈,酞菁等衍生的抗癌試劑,BCL蛋白與細胞調亡劑,拓撲異構酶抑制劑、光動力治療劑,色素的藥物化學(抗腫瘤先導、DNA嵌入劑、細胞調亡劑)

研究方向2.農藥的化學與生物學

其研究主要體現在芳香雜環或氟化合物衍生的農藥先導,包括以下內容:

農藥先導:昆蟲生長調節劑、昆蟲行為調節劑、幾丁質合成抑制、蛻皮激動、飛行調控、海藻糖酶抑制,拒食,尼古丁受體激動,殺蟲劑,除草劑,殺菌劑。

新雜環化合物:氟化合物,氟烷氧基化合物,芳香雜環,硫化合物,惡二唑、噻二唑、噠嗪酮、新菸鹼、環亞胺、二芳醯基肼

研究方向3.化學生物技術與工程

其研究主要體現在人工核酸酶,細胞激活劑和生物轉化,包括以下方面:

人工核酸酶:由萘醯亞胺、硫雜環衍生的人工光核酸酶,光降解,人工核酸水解酶,DNA切斷劑,生物製備過程中轉基因物質的去除。

細胞激活劑:由茉莉酮酸酯、苯並噻二唑等衍生的細胞激活劑,用於人參、紫杉烷、靈芝的次生代謝物的增產與調控。

生物轉化:酵母,植物細胞,立體選擇性還原,化學選擇性還原,芴,芳香硝基、胺、羥胺、酮還原、手性醇。

主要成就

獲得榮譽

1992霍英東基金會高校優秀青年教師獎(科研類);

1995全國優秀教師;

1996國務院政府特殊津貼;

1997入選國家百千萬人才工程(第一、二層次);

1998中國青年科技獎;

1999第六屆上海十大科技精英;

1994國家教委科技進步一等獎(第二完成人);

1998上海市科技進步三等獎(第一完成人);

1998國家教育部科技進步一等獎(第一完成人);

2002國家教育部科技進步一等獎(第一完成人);

2003國家教育部自然科學一等獎(第一完成人);

2000國家傑出青年科學基金獲得者;

2001大連市優秀專家;

2001中國化工學會農藥委員會副主任委員。J.FluorineChemistry,PesticideBiochemistryandPhysiology等編委,在ChemCommun.,Org.Lett.,JACS等SCI國際學報發表論文近百十篇。專利十數項。此外,

2003擔任國家重點基礎研究發展規劃(973計畫)項目首席科學家

2003國務院學位委員會學科評議組成員;

2004國家自然科學基金委員會第十屆有機化學評議組成員,第十一屆化工評議組成員;

2007亞洲及太平洋化工聯盟主席;

2011中國工程院院士。

研究成果

上地幔變形作用和地球化學性質之間的關係及其深部動力學意義。

運用綜合研究方法,探討了伊通新生代玄武岩中特有的具糜棱結構的橄欖岩包體所經歷的構造熱演化及動力學,證實了上地幔韌性剪下帶的存在。強調其形成與超大斷裂活動性之間的關係;並首次發現了橄欖岩包體中礦物顆粒間的氧同位素不平衡現象,為地幔剪下變形和地幔交代作用提供了時間約束,認為流體的存在並不是剪下變形的先決條件,從而為地幔學術界長期爭論的流體和地幔變形之間的因果關係提供了新的判別依據。根據吉林汪清尖晶石相橄欖岩包體結構、平衡溫度、主元素虧損程度和不相容元素富集程度之間的相關關係,提出了上地幔底辟上升和熱擴散平衡的動力學模式,闡明了不同結構類型包體在底辟體中的空間展布及其對交代流體遷移的控制。認為所有研究樣品均來自岩石圈地幔,但由於下伏軟流圈的上涌而導致其流變學性質的改變,從而同軟流圈一起發生底辟。這一成果為華北自中生代以來發生的大規模熱侵蝕-減薄機制提供了一個可行的動力學模式。

上地幔熔體-岩石反應機理及其微量元素理論模擬通過對伊通含富鉀矽酸鹽玻璃體的異剝橄欖岩和法國中央高原具鑲嵌結構I型尖晶石相方輝橄欖岩包體的研究,橄欖岩包體的研究,鑑定出了單斜輝石生成反應和橄欖石生成反應兩個系列。這是對構造橄欖岩體研究的重要補充,對地幔不均一性及岩漿源區混合作用的研究具有重要意義。後者還提供了岩石圈最底部-地幔熱柱相互作用的證據。運用0-維數值模型計算了微量元素在上地幔熔體遷移/反應過程中地球化學行為。該成果對認識熔體/流體在深部岩石圈地幔演化過程中的作用具有重要意義。

地幔地質溫壓計的檢測,

套用和中國東部地幔岩石圈熱演化系統總結和科學評價了常用的二十多種溫度計和五種壓力計的優缺點,為國內學者更加審慎地選用溫壓計提供了依據,在此基礎上,探討了中國東部上地幔熱結構和熱演化歷史。以在特定熱演化階段中古老岩石圈/軟流圈相互作用程度為思路,結合實驗岩石學資料和岩石圈拉張歷史,提出了一個熱-構造演化模式,從而比較合理地解釋了中國東部中生代末期-新生代玄武岩的岩性,微量元素和同位素地球化學演化特徵,為深部地幔研究提供了新思路。

中國東部幔源橄欖岩的鉑族元素地球化學研究在國內率先開展了中國東部幔源橄欖岩的PGE地球化學研究,填補了中國在地幔岩PGE研究領域的空白。初步了解了不同類型岩石中這些元素的豐度和分布規律,揭示了中國東部上地幔特有的PGE分配型式(即富集Pt,虧損Ir和Pd)。探討了PGE在多種重要上地幔過程中的地球化學行為。

學術論文

研究方向1.染料的化學生物學

ORG.LETT.-2006-3721:AseriesofpolyamidereceptorbasedPETfluorescentsensormolecules:PositivelycooperativeHg2+ionbindingwithhighsensitivity

ORG.LETT.2005-3029:Colorimetricandratiometricfluorescentchemosensorwithalargered-shiftinemission:Cu(Ⅱ)-onlysensingbydeprotonationofsecondaryaminesasreceptorconjugatedtonaphthalimidefluorophore

ORG.LETT.-2005-889:RatiometricandselectivefluorescentsensorforCu-Ⅱbasedoninternalchargetransfer(ICT)

ORG.LETT.2004-2757:NovelfluorescentpHsensorsbasedonintramolecularhydrogenbondingabilityofnaphthalimide(SS)

J.ORG.CHEM.-2006-4308:DetectingHg2+ionswithanICTfluorescentsensormolecule:Remarkableemissionspectrashiftanduniqueselectivity

J.ORG.CHEM.-2007-3554:RatiometricandhighlyselectivefluorescentsensorforcadmiumunderphysiologicalpHrange:Anewstrategytodiscriminatecadmiumfromzinc

CHEM.COMMUN.-2006-109:TworegioisomericandexclusivelyselectiveHg(Ⅱ)sensormoleculescomposedofanaphthalimidefluorophoreandano-phenylenediaminederivedtriamidereceptor

CHEM.COMMUN.-2005-239:Anewclassoflong-wavelengthfluorophores:strongredfluorescence,convenientsynthesisandeasyderivation

CHEM.COMMUN.-2001-2656:Intramoleculararomatic1,5-hydrogentransferinpreparationofoxacyclicnaphthalicanhydrideviaunusualPschorrcyclisation

NEWJ.CHEM.-2003-337:Apolyamidoaminedendrimerwithperipheral1,8-naphthalimidegroupscapableofactingasaPETfluorescentsensorformetalcations

NEWJ.CHEM.-2002-920:NovelheterogeneousPETfluorescentsensorsselectivefortransitionmetalionsorprotons:polymersregularlylabelledwithnaphthalimide

J.AM.CHEM.SOC.-2004-2272:AhighlyselectiveandsensitivefluorescentchemosensorforHg2+inneutralbufferaqueoussolution

KIDNEYINTERNATIONAL-2004-2279:Fluorescentimagingofacutemercuricchlorideexposureonculturedhumankidneytubularepithelialcells

CHEM.RES.TOⅪC.-2005-1814:Visiblestudyofmercuricionanditsconjugateinlivingcellsofmammalsandplants

CHEMBIOCHEM-2007-113:NovelBcl-2inhibitors:Discoveryandmechanismstudyofsmallorganicapoptosis-inducingagents(SS)

J.MATER.CHEM.-2005-2836:ApH-resistantZn(Ⅱ)sensorderivedfrom4-aminonaphthalimide:design,synthesisandintracellularapplications

MOL.CANCERTHER.-2007-484:R16,anovelamonafideanalogue,inducesapoptosisandG2-MarrestviapoisoningtopoisomeraseⅡ(SS)

BIOORG.MED.CHEM.LETT.-2006-1562:Synthesisandevaluationofnovel8-oxo-8H-cyclopenta[a]acenaphthylene-7-carbonitrilesaslong-wavelengthfluorescentmarkersforhypoxiccellsinsolidtumor

BIOORG.MED.CHEM.LETT.-2005-5909:Novelsyntheticisoquinolino[5,4-ab]phenazines:InhibitiontowardtopoisomeraseI,antitumorandDNAphoto-cleavingactivities

BIOORG.MED.CHEM.LETT.-2005-4864:NovelthiazonaphthalimidesasefficientantitumorandDNAphotocleavingagents:Effectsofintercalation,sidechains,andsubstituentgroups(SS)

BIOORG.MED.CHEM.LETT.-2005-4864:Synthesis,antitumorevaluationandDNAphotocleavingactivityofnovelmethylthiazonaphthalimideswithaminoalkylsidechains(SS)

BIOORG.MED.CHEM.LETT.-2005-1139:Five-memberthio-heterocyclicfusednaphthalimideswithaminoalkylsidechains:intercalationandphotocleavagetoDNA(SS)

BIOORG.MED.CHEM.LETT.-2003-5427:Novelnaphthalimidehydroperoxidephotonucleases:Theroleofthiocyclic-fusedareaandthedifferenceinspectra,photochemistryandphotobiologicalactivity(SS)

BIOORG.MED.CHEM.-2007-1356:Novelantitumoragentfamilyof1H-benzo[c,d]indol-2-onewithflexiblebasicsidechains:Synthesisandbiologicalevaluation(SS)

BIOORG.MED.CHEM.-2006-6962:Acenaphtho[1,2-b]pyrrolederivativesasnewfamilyofintercalators:VariousDNAbindinggeometryandinterestingantitumorcapacity(SS)

BIOORG.MED.CHEM.-2006-4639:Design,synthesis,andantitumorevaluationofnovelacenaphtho[1,2-b]pyrrole-carboxylicacidesterswithaminochainsubstitution(SS)

BIOORG.MED.CHEM.-2005-3149:Novelheterocyclicfamilyofphenylnaphthothiazolecarboxamidesderivedfromnaphthalimides:synthesis,antitumorevaluation,andDNAphotocleavage(SS)

BIOORG.MED.CHEM.-2005-1615:Thio-heterocylicnaphthalimideswithaminoalkylsidechains:novelalternativetoolsforphotodegradationofgenomicDNAwithoutimpairmentonbioactivitiesofproteins(SS)

TETRAHEDRONLETT.-2005-6289:Aprotonsponge-basedfluorescentswitch

TETRAHEDRONLETT.-2004-3969:AnovelchromatismswitcherwithdoublereceptorsselectivelyforAg+inneutralaqueoussolution:4,5-diaminoalkeneamino-N-alkyl-1,8-naphthalimides

TETRAHEDRONLETT.-2003-2087:Novelhighlyefficientfluoroionophoreswithaperi-effectandstrongelectron-donatingreceptors:TICT-promotedPETandsignalingresponsetotransitionmetalcationswithlowbackgroundemission

TETRAHEDRONLETT.-2003-795:Promotingeffectsofthehydroxymethylgrouponthefluorescentsignalingrecognitionofanionsbythioureas

TETRAHEDRONLETT.-2002-2991:4-Amino-1,8-dicyanonaphthalenederivativesasnovelfluorophoreandfluorescenceswitches:efficientsynthesisandfluorescenceenhancementinducedbytransitionmetalionsandprotons

TETRAHEDRONLETT.-2002-2995:Synthesisandpropertiesofbenzothioxanthenedicarboximidehydroperoxide:anefficient'time-resolved'DNAphotocleaverwithlong-wavelength(SS)

TETRAHEDRONLETT.-2001-6175:N-aroyloxynaphthalimidesasnovelhighlyefficientDNAphotocleavers:substituenteffects

TETRAHEDRONLETT.-2000-7711:NovelandhighlyefficientDNAphotocleavers:hydroperoxidesofheterocyclic-fusednaphthalimides

TETRAHEDRON-2005-11895:NovelDNAbis-intercalatorsofisoquinolino[4,5-bc]acridines:design,synthesisandevaluationofcytotoxicactivity

TETRAHEDRON-2005-8717:Synthesis,antitumorandDNAphotocleavingactivitiesofnovelnaphthalenecarboxamides:effectsofdifferentthio-heterocyclicringsandaminoalkylsidechains(SS)

TETRAHEDRON-2005-6634:Synthesisofthiazo-orthiadiazo-naphthalenecarboxamidesviamercuricintermediatesandtheirantitumorandDNAphotocleavageactivities(SS)

TETRAHEDRON-2006-10117:ExploitingthedeprotonationmechanismforthedesignofratiometricandcolorimetricZn2+fluorescentchemosensorwithalargered-shiftinemission

DYESPIGMENTS-2002-247:Synthesisandpropertiesofoligonucleotidescontainingfluorescentethenodeoxyadenosineandethenodeoxycytidine

DYESPIGMENTS-2001-51:Absorptionandfluorescencespectralpropertiesoftetra(fluoroalkoxy)metallophthalocyanines(FF)

DYESPIGMENTS-2001-43:Oxazolonaphthalimidesandtheirhydroperoxides:photophysicalandphotobiologicalproperties

DYESPIGMENTS-2004-9:BenzothioxanthenedyesasfluorescentlabelforDNAhybridization:synthesisandapplication(SS)

DYESPIGMENTS-2004-17:Synthesisandperoxidase-stainingpropertiesofnovelwatersolublepolyhydroxylalkylbenzidinedyes

J.FLUORINECHEM.-2002-161:Synthesisandphotosensitizingpropertiesoffluoroalkoxylphthalocyaninemetalcomplexes(FF)

J.FLUORINECHEM.-2000-69:Synthesisoffluorine-containingoxazolonaphthalimidehydroperoxidesasDNAphotocleavers(FF)

CHINESEJ.ORG.CHEM.1997-329:Synthesisandcharacterizationsofthedyesensitizedphotooxygenationproductsandtheheterocyclesofnaphthofuranderivatives

CHINESEJ.ORG.CHEM.-1997-428:Synthesis,characterizationandDNAintercalationofafuronaphthopyrononeasanovelanalogueoffurocoumarin

CHINESEJ.ORG.CHEM.-2000-338:Synthesisandstructurecharacterizationoftwothienonaphthopyrones(SS)

CHINESEJ.ORG.CHEM.2006-504:SynthesisandpropertiesofN-butyl-4-(aza-15-crown-5)-1,8-naphthalimideasafluorescentprobe

CHEM.RESEARCHINCHINESEUNⅣ.-2005-480:Anovelphotocleaverwithlongwavelengthabsorption-Highlyefficientantitumoragent:4-(2-diethylamino-ethylamino)-8-oxo-8H-acenaphtho-[1,2-b]pyrrole-9-carbonitrile

CHEM.J.CHINESEUNⅣ.-1996-1399:Syntheses,DNAIntercalationActivitiesandMolecularModellingonStructuresofTatramethyldifuronaphthalenes

J.PHOTOCHEM.PHOTOBIO.B-2001-35:Tetra-trifluoroethoxylzincphthalocyanine:potentialphotosensitizerforuseinthephotodynamictherapyofcancer(SS)

J.PHOTOCHEM.PHOTOBIO.B-2006-221:Isoquino[4,5-bc]acridines:Design,synthesisandevaluationofDNAbinding,anti-tumorandDNAphoto-damagingability

J.CHEM.SOC.-PERKINTRANSACTIONS2-2000-715:InteractionofnaphthylheterocycleswithDNA:effectsofthionoandthiogroups(SS)

MONATSHCHEM.-1999-1109:SynthesisofnovelDNA-intercalatingnaphthopyronederivativeswithimprovedwatersolubilityandphotophysicalproperties

BULL.CHEM.SOC.JAPAN-1999-1571:HighlyefficientphotoinducedDNAcleavagebynaphthopyronehydroperoxides

CHEM.LETT.-2005-696:Novelnaphthalimidefluorescentsensorsselectiveforcertainproteinsonbasisofnon-covalentinteractionsbetweenenzymeandinhibitor(SS)

SYNTHESIS-STUTTGART-1999-1109:Generalsynthesisofthioxo-1,8-naphthalimidesviathioxo-1,8-naphthalicanhydrides(SS)

HETEROATOMCHEM.-1999-141:Theimprovedsynthesis,Diels-Alderreactions,anddesulfurationoftrithio-1,8-naphthalicanhydride(SS)

POLYMER-2002-5731:Synthesisandphotophysicalpropertiesof1,8-naphthalimide-labelledPAMAMasPETsensorsofprotonsandoftransitionmetalions

CHINESEJ.ANAL.CHEM.-2004-837:Studiesontheroomtemperaturephosphorescenceofhalogennaphthalicanhydrides

CHINESECHEM.LETT.-2004-118:AnthracylmethylbenzoazacrownetherasselectivefluorescencesensorsforZn2+

HETEROCYCL.COMMUN.-2003-229:AnewclassofDNAintercalatorandphotocleaver:Bis-naphthailimideswithbromoandnitrosubstituents

MONATSH.CHEM.-2003-393:Newfluorescentconjugatesofuridinenucleosideandsubstituted1,8-naphthalimide:Synthesis,weakinteractionsandsolventeffectsonspectra

INT.J.BIO.MACROMOL.-2006-59:Studyontheinteractionbetween4-(2-diethylanuno-ethylamino)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrileandDNAbymolecularspectra

研究方向2.農藥的化學與生物學

J.AGRI.FOODCHEM.-2007-2288:Synthesis,insecticidalactivity,andQSARofnovelnitromethyleneneonicotinoidswithtetrahydropyridinefixedcisconfigurationandexo-ringethermodification

J.AGRI.FOODCHEM.-2006-125:Synthesisandherbicidalactivityofnovel3-aminocarbonyl-2-oxazolidinethionederivativescontainingasubstitutedpyridinering

J.AGRI.FOODCHEM.-2006-8793:Novel,unnaturalbenzo-1,2,3-thiadiazole-7-carboxylateelicitorsoftaxoidbiosynthesis(SS,FF)

J.AGRI.FOODCHEM.-2005-3120:Syntheses,antifeedantactivity,andQSARanalysisofnewoxa(thia)diazolyl3(2H)-pyridazinones(SS)

J.AGRI.FOODCHEM.-2005-3120:Syntheses,AntifeedantActivity,andQSARAnalysisofNewOxa(thia)diazolyl3(2H)-Pyridazinones(SS)

J.AGRI.FOODCHEM.-2003-152:SynthesisandAntifeedantActivityofNewOxadiazolyl3(2H)-Pyridazinones

J.AGRI.FOODCHEM.-2001-124:SynthesisandQuantitativeStructure-ActivityRelationshipsofNew2,5-Disubstituted-1,3,4-oxadiazoles(FF)

J.AGRI.FOODCHEM.-2001-5279:SynthesisandQuantitativeStructure-ActivityRelationshipsofFluorine-Containing4,4-Dihydroxylmethyl-2-arylimino-oxazo(thiazo)lidinesasTrehalaseInhibitors(SS,FF)

J.AGRI.FOODCHEM.-1999-4415:Quantitativestudiesonstructure-activityrelationshipofsulfonylureaandbenzoylphenylureatypepesticidesandtheirsubstituents'bioisosterismusingsynthons'activitycontribution(SS,FF)

J.AGRI.FOODCHEM.-1996-1538:Molecularmodelingstudyonthestructure-activityrelationshipofsubstituteddibenzoyl-1-tert-butylhydrazinesandtheirstructuralsimilarityto20-hydroxyecdysone

ACSSYMPOSIUMSERIES-2005(892)-273:Oxadiazolederivativesasnovelinsect-growthregulators:Synthesisandstructure-bioactivityrelationship(FF)

J.FLUORINECHEM.-2006-182:Synthesisandherbicidalactivitiesoffluorine-containing3-pyridylmethyl-2-phenyliminothiazolidinederivatives(SS,FF)

J.FLUORINECHEM.-2005-297:Synthesisandfungicidalactivityoffluorine-containingphenylimino-thiazolidinesderivatives(SS,FF)

J.FLUORINECHEM.-2005-53:Synthesisandbiologicalactivitiesofhydroxyl-protectedfluorine-containing4,4-dihydroxylmethyl-2-aryl-iminothiazolidines(SS,FF)

J.FLUORINECHEM.-2004-1159:SynthesisandfungicidalactivityofFluorine-containingPhenylimino-thiazolidinesDerivatives(SS,FF)

J.FLUORINECHEM.-2004-1609:Syntheses,structuresandbioactivitiesoffluorine-containingphenylimino-thia(oxa)zolidinederivativesasagriculturalbioregulators(SS,FF)

J.FLUORINECHEM.-2003-163:Synthesisandinsecticidalactivitiesofnovel2,5-disubstituted1,3,4-oxadiazoles(FF)

J.FLUORINECHEM.-2003-51:SynthesisandinsecticidalactivityofnewsubstitutedN-aryl-N’-benzoylthioureacompounds(SS,FF)

J.FLUORINECHEM.-2002-63:Synthesesandinsecticidalactivityofnew2-(5-(trifluoromethyl)pyridyloxymethyl)-1,3,4-oxadiazoles](FF)

J.FLUORINECHEM.-2000-111:Fluorinecontainingheterocycliccompounds:synthesisof6-substituted-2-substituted-aryl-1,2,4-triazolo[5,1-b]1,3,5-thia-diazin-7-onederivatives(SS,FF)

J.FLUORINECHEM.-2000-173:Synthesesandinsecticidalactivitiesofnovel2-fluorophenyl-5-aryl/cyclopropyl-1,3,4-oxadiazoles(FF)

J.FLUORINECHEM.-2001-143:Synthesisandbiologicalactivitiesoffluorine-containingN,N’-diphenylcarbamimidothioates(SS,FF)

J.FLUORINECHEM.-1999-39:Synthesesandcharacterizationof2-amino-5-aryl-1,3,4-oxadiazolescontainingtrifluoroethoxygroups(FF)

J.FLUORINECHEM.-1998-9:Polyfluoroalkoxylationandmethoxylationofpolychloropyridines(FF)

J.FLUORINECHEM.-1996-9:Alcoholysisoftrifluoromethylgroupsattachedtothepyridinering(FF)

J.FLUORINECHEM.-1991-143:AsyntheticandMO-SCFstudyofthetrifluoroethoxylationofchloro(trifluoromethyl)pyridinederivatives(FF)

CHEM.PHYS.LETT.-2003-489:Intramolecularnoncovalentforceincyclicamidines:nonbondedinteractionbetweencarbonatomsandheteroatoms(SS,FF)

PEST.MANAG.SCI.-2003-933:Thetoxicandanti-feedantactivityof2H-pyridazin-3-one-substituted1,3,4-oxadiazolesagainstthearmywormPseudaletiaseparata(Walker)andotherinsectsandmite

CARBOHYDRATERESEARCH-2001-79:SynthesesandactivitiesastrehalaseinhibitorsofN-arylglycosylaminesderivedfromfluorinatedanilines(FF)

J.CHEM.TECH.BIOTECH.-1996-124:Synthesesandinsecticidalactivitiesofnovel2,5-disubstituted-1,3,4-oxadiazoles(FF)

CAN.J.CHEM.-2003-272:N'-tert-Butyl-N'-aroyl-N-(alkoxycarbonylmethyl)-N-aroylhydrazines,anovelnonsteroidalecdysoneagonist:syntheses,insecticidalactivity,conformationalandcrystalstructureanalysis

MONATSHCHEM.-2006-779:Anefficientandpracticalmethodforthesynthesisof1-(2,6-difluorobenzoyl)-3-(2-alkyl-3-oxopyridazin-4-yl)ureasaspotentialchitinsynthesisinhibitors(FF)

MONATSHCHEM.-2000-953:Novelfusedheterocycles:Synthesisandactivityof5,6-dihydro-7-thia-1,3,3a,5-tetraazainden-4-oneand1-thia-3,4a,9-triazafluoren-4-onederivatives(SS)

J.CHEM.RES.-2006-626:Synthesisandbioactivitiesofnovelneonicotinoidsdioxolanecompounds

J.CHEM.RES.-2000-88:Thecrystalstructureof1-phenyl-3-methyl-5-[2'-(4''-phenylmethoxylphenyl)ethoxyl]pyrazole,apotentialinsectjuvenilehormonemimic

J.CHEM.RES.-1999-66:ThecrystalstructureofN-(5-phenyl-1,3,4-oxadiazol-2-yl)-N'-benzoylurea,anovelinsect-growthregulator

J.CHEM.RES.-1998-478:Crystalstructureof1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea,aninhibitorofchitinsynthesis(SS,FF)

CHEM.J.CHINESEUNⅣ.-1994-224:Synthesisandbioactivitiesofnoveltrifluoromethylpyridinederivatives

CHINESECHEM.LETT.-2004-7:NovelAnaloguesof-Terthienyl,Thienyl1,3,4-Thia(oxa)diazolesasPotentialPhotoactivatedInsecticides:SynthesisandBioactivity(SS)

PESTICIDEBIOCHEM.PHYSIOLOGY-2004-42:Photolarvicidaleffectofthienyl1,3,4-thia(oxa)diazolesandtheirpotentialDNAphotocleavage(SS)

ARKⅣOC-2003-141:Synthesisandinsecticidalactivityof1,2,4-triazolederivatives

CHEM.LETT.-2001-54:ANovelandPracticalAminationof4,5-Dichloropyridazin-3-onesviaReductionwithHydrazineHydrate

ORG.PREP.PROCEDUREINTL.-2000-571:Afacilesynthesisofarylisothiocyanatesfromarylamines(SS)

ORG.PREP.PROCEDUREINTL.-1999-110:Afacilesynthesisof3-chloro-4-(2',2',2'-trifluoroethoxy)benzonitrile(FF)

研究方向3.化學生物技術與工程

CHEM.COMMUN.-2006-865:Baker'syeast-mediatedenantioselectivereductionofsubstitutedfluorenones(FF)

CHEM.COMMUN.-2005-2338:Anovelstrategyforthepreparationofarylhydroxylamines:chemoselectivereductionofaromaticnitrocompoundsusingbakers'yeast

CHEM.COMMUN.-2004-2339:Anovelstrategyforthepreparationofarylhydroxylamines:chemoselectivereductionofaromaticnitrocompoundsusingbakers’yeast

APPL.MICROBIO.BIOT.-2005-98:Anovelsyntheticfluoro-containingjasmonatederivativeactsasachemicalinducingsignalforplantsecondarymetabolism(FF)

APPL.MICROBIOL.BIOT.-2006-164:Novelsynthetic2,6-dichloroisonicotinatederivativesaseffectiveelicitorsforinducingthebiosynthesisofplantsecondarymetabolites

APPLIEDMICROBIO.BIOTECH.-2006-298:EfficientinductionofginsenosidebiosynthesisandalterationofginsenosideheterogeneityincellculturesofPanaxnotoginsengbyusingchemicallysynthesized2-hydroxyethyljasmonate

BIOORG.MED.CHEM.LETT.-2005-1769:Novel2-aminothiazonaphthalimidesasvisiblelightactivatablephotonucleases:effectsofintercalation,heterocyclic-fusedareaandsidechains(SS)

BIOORG.MED.CHEM.LETT.-2003-3513:Thiadiazole:Anewfamilyofintercalativephotonucleasewithelectrontransferandradicalmechanisms(SS,FF)

BIOORG.MED.CHEM.LETT.-2004-2665:Highly-efficientDNAphotocleaverswithlongwavelengthabsorptions:thio-heterocyclicfusednaphthalimidescontainingaminoalkylsidechains(SS)

BIOORG.MED.CHEM.LETT.-2004-2335:N-aroyloxylthioxo-naphthalimidesasDNAphotocleaversofaroyloxyloxygenradicals:synthesis,evaluation,andsubstituents'effect(SS)

BIOORG.MED.CHEM.LETT.-2004-4755:Novelfluoro-andhydroxyl-containingjasmonatederivativesashighlyefficientelicitorsinsuspensionculturesofTaxuschinensis(FF)

BIOORG.MED.CHEM.LETT.-2006-803:HydrolysisofplasmidDNAandRNAbyaminoalkylnaphthalimideasmetal-freeartificialnuclease(SS)

BIOORG.MED.CHEM.-2006-2935:Novelfluorescentmarkersforhypoxiccellsofnaphthalimideswithtwoheterocyclicsidechainsforbioreductivebinding

BIOORG.MED.CHEM.-2006-23:Eliminatingnucleicacidscontaminantsbyhydrogenperoxide-inducedfreeradicalsduringthepreparationofproteins(SS)

BIOTECH.BIOENG-2005-516:Highlyefficientstrategyforenhancingtaxoidproductionbyrepeatedelicitationwithanewlysynthesizedjasmonateinfed-batchcultivationofTaxuschinensiscells

BIOTECH.BIOENG.-2004-809:Novelchemicallysynthesizedhydroxyl-containingjasmonatesaspowerfulinducingsignalsforplantsecondarymetabolism

BIOTECH.BIOENG.-2004-595:NovelsyntheticjasmonatesashighlyefficientelicitorsfortaxoidproductionbysuspensionculturesofTaxuschinensis

BIOTECH.PROGR.-2006-331:Novelchemicallysynthesizedsalicylatederivativeasaneffectiveelicitorforinducingthebiosynthesisofplantsecondarymetabolites

BIOTECH.ANDBIOPROCESSENGI.-2005-162:EfficientelicitationofginsenosidebiosynthesisincellculturesofPanaxnotoginsengbyusingself-chemically-synthesizedjasmonates

BIOCHEM.ENGINEERING.J.-2006-23:Eliminatingnucleicacidscontaminantsbyhydrogenperoxide-inducedfreeradicalsduringthepreparationofproteins

TETRAHEDRONLETT.-2004-1247:Naphthalimide-thiazolesasnovelphotonucleases:moleculardesign,synthesis,andevaluation(SS)

TETRAHEDRON-2005-11264:Versatileacenaphtho[1,2-b]pyrrol-carbonitrilesasanewfamilyofheterocycles:diverseSnar(H)Hreactions,cytotoxicityandspectralbehavior(SS)

DYESANDPIGMENTS-1999-139:Naphthalimidehydroperoxidesasphotonucleases:substituenteffectsandstructuralbasis

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