人物簡介
博士後史丹福大學2005-2009
博士中國協和醫科大學2000-2005
學士白求恩醫科大學1989-1994二、工作經歷
2009-至今南開大學醫學院
2005-2009史丹福大學放射系，分子影像中心三、研究方向
主要從事
幹細胞治療，人胚胎幹細胞的分化，組織工程，腫瘤幹細胞及分子影像學的研究，在國際上率先套用胚胎幹細胞來源的內皮細胞用於缺血性心臟病的治療。同時，套用納米脂質體聯合分子影像技術靶向腫瘤幹細胞的研究也得到了較高的評價。包括在NatureMethods,Circulation,JAmCollCardiol,StemCells,CanerRes，Stroke,Biomaterials等雜誌發表論文40餘篇，其中SCI論文36篇，被引用超過800次。參與了3部專著的撰寫，申請了2項發明專利。研究工作先後獲得多項獎勵，包括：2007年美國血管生物學學會優秀青年科學家獎、2008年美國心臟病學會優秀青年科學家獎、2009年史丹福大學心血管研究所優秀青年科學家獎、MitziandWilliamBlahd,MD啟動基金第一名等。
在研項目
1)國家重大科學研究計畫項目973（項目編號：2011CB964903）2011-2015
經費：￥4,620,000，為研究骨幹，經費來源：科技部。研究課題“多潛能幹細胞特異性誘導分化及其表觀遺傳學調控在治療糖尿病中的套用基礎研究”，子課題“在體胰島組織和腎上皮組織幹細胞歸巢、複製、分化的示蹤新技術與新方法”。研究內容:建立MSC和ESC在小動物的分子影像監測技術，利用分子影像技術，評價MSC和ESC在糖尿病和腎功能衰竭中的作用;建立大動物模型，引進PET，MRI等分子影像技術，監測其在大動物體內功能的改變。
2)國家自然科學基金（項目批准號：31071308）2011-2013
經費：￥370，000，項目主持人，經費來源：國家自然科學基金委。研究課題“非病毒微載體重編程心臟幹細胞為誘導多能幹細胞(iPSC)的研究”。3)2010年度高等學校博士學科點專項科研基金.經費：￥60,000，為研究骨幹，經費來源：教育部。研究課題“非病毒微載體重編程心臟幹細胞為誘導多能幹細胞的研究”。
4）天津套用基礎與前沿技術研究計畫（自然科學基金）重點項目2012-2014
經費：￥200，000，項目主持人，經費來源：天津科委。
5）國家教育部留學回國人員科研啟動金
經費：￥35，000，項目主持人，經費來源：教育部。
學術兼職
1．2009-至今CirculationResearch雜誌審稿人
2.2009-至今PeerReviewerfortheAmericanHeartAssociation
3.2010StemCellsInternational客座主編
4.2010-至今自然科學基金面上項目評審
5.2010-2012AmericanJournalofNuclearMedicineandMolecularImaging編委
6.2912-2014中國組織工程研究雜誌執行編委
7.2012-高等學校博士學科點專項科研基金網路評審專家
8.2012-教育部學位中心“省市優秀碩士學位論文評選”通訊評議評審專家
專利：
1.具有腫瘤靶向、體內示蹤和治療作用的脂質體藥物組合物及製備方法，第一發明人
2.具有腫瘤靶向、體內示蹤和治療作用的人胚胎幹細胞來源的內皮細胞,第一發明人
講授課程
1．病理生理學
2．幹細胞生物學
七、榮譽和獎勵2006美國心臟學會(AHA)牆報前10名
2006-2007史丹福大學博士後基金
2007美國血管生物學會JayD.Coffman優秀青年科學家獎
2008第57屆美國心臟病學會(ACC)優秀青年科學家獎
2008ACCF/Bristol-MyersSquibbTravelAward,美國心臟病學會(ACC)
2008史丹福大學醫學院心血管病研究所，優秀青年科學家獎
2008國際幹細胞學會(ISSCR)TravelAward
2008MitziandWilliamBlahd,MD啟動基金第一名,美國核醫學會
2009JournalofCellularBiochemistry,2009年106卷第2期封面文章
2010發表在Stroke,2010,41(3):516-23的文章被F1000選中.
2012南開大學第四屆良師益友提名獎
近年論文
（*通訊作者）
1.SuW,WangL,ZhouM,TongL,LiuZ,HuS,LiuF,LiuY,YanF,KongD,HanZ,WuJC,XiangR,LiZ*.HumanEmbryonicStemCell-derivedEndothelialCellsasCellularDeliveryVehiclesforTargetingTherapyofBreastCancer.Submitted
2.JiaX,XieX,FengG,YaoX,LüH,MaoL,ZhaoQ,CheY,HanZ,XuY,LiZ*,KongD*.Bonemarrow-derivedcellscanacquirerenalstemcellspropertiesandameliorateischemia-reperfusioninducedacuterenalinjury.BMCNephrology.2012inpress.(IF,2.2)
3.DaadiMM,HuS,KlausnerJ,LiZ,SofilosM,SunG,WuJC,SteinbergGK.ImagingNeuralStemCellGraft-InducedStructuralRepairinStroke.CellTransplantation.2012inpress.(IF,6.2)
4.LuD,ChenS,TanX,LiN,LiuC,LiZ,LiuZ,StupackDG,ReisfeldRA,XiangR.Fra-1PromotesBreastCancerChemosensitivitybyDrivingCancerStemCellsfromDormancy.CancerRes,2012,72(14):3451-6.Link(IF,8.2)
5.WangL,SuW,LiuZ,ZhouM,ChenS,ChenY,LuD,LiuY,YanF,ZhengY,HanZ,KongD,WuJC,XiangR*,LiZ*.CD44AntibodyTargetedLiposomesforMolecularImagingandTherapyofHepatocellularCarcinoma.Biomaterials.2012,33(20):5107-5114Link(IF,7.8)
6.WangL,ChenS,ZhangM,ChenY,SuW,LiuY,LuD,LiS,YangY,LiZ,QuP,HuH,XiangR.LegumainServesasaBiomarkerfortheDiagnosisandPrognosisofHumanOvarianCancer.JofCellBiochem.2012,113(8):2679-86.Link(IF,3.1)
7.ZhouM,WangL,SuW,TongL,LiuZ,LiuY,YanF,ZhengY,ZhaoH,XiangR*,LiZ*.AssessmentofTherapeuticEfficacyofLiposomalNanoparticlesMediatedGeneDeliverybyMolecularImagingforCancerTherapy.JBiomedNanotechnol.2012,8(5):742-750.Link(IF,4.2)
8.FengG,CuiJ,ZhengY,HanZ,XuY*,LiZ*.Identification,CharacterizationandBiologicalSignificanceofVerySmallEmbryonic-LikeStemCells(VSELs)inRegenerativeMedicine.HistolHistopathol.2012,27(7):827-833.PMID:22648539Link.(IF,2.5)
9.ZhangJ,JiaX,XuZ,DingF,ZhouX,FuH,LiuY,OuL,LiZ,KongD.ImprovedMesenchymalStemCellSurvivalinIschemicHeartThroughElectroacupuncture.ChinJIntegrMed.2012,DOI:10.1007/s11655-012-1101-3.Link.(IF,0.799)
10.ZhangZ,YinJ,ZhangC,LiangN,BaiN,ChangA,LiuY,LiZ,TanX,LiN,LvD,XiangR,TianY,LiuC.Activatingtranscriptionfactor4increaseschemotherapeuticsresistanceofhumanhepatocellularcarcinoma.CancerBiology&Therapy,2012,13(6)435-442.Link(IF,2.9)
11.HuS,HuangM,NguyenP,GongY,LiZ,JiaF,LanF,LiuJ,NagD,RobbinsRC,WuJC.NovelMicroRNAPro-survivalCocktailforImprovingEngraftmentandFunctionofCardiacProgenitorCellTransplantation.Circulation.2011,124:S27-S34.Link(IF,14.8)(Top3advancesinAHABasicCardiovascularSciencesin2011)
12.LiZ,HuS,GhoshZ,HanZ,WuJC.FunctionalCharacterizationandExpressionProfilingofHumanInducedPluripotentStemCell-andEmbryonicStemCell-DerivedEndothelialCells.StemCellsDev.2011,20(10):1701-1710.Link(IF,4.8)
13.SuW,ZhouM,ZhengY,FanY,HanZ,KongD,ZhaoRC,WuJC,XiangR*,LiZ*.Bioluminescencereportergeneimagingcharacterizehumanembryonicstemcell-derivedteratomaformation.JCellBiochem.2011,112:840–848.Link.(IF,3.1)
14.WangY,WangYanming,WangL,CheY,LiZ*,KongD*.Preparationandevaluationofmagneticnanoparticlesforcelllabeling.JournalofNanoscienceandNanotechnology.2011,11:3749-3756.Link(IF,1.9)
15.XieX,HionaA,LeeA,CaoF,HuangM,LiZ,CherryA,PeiX,WuJC.EffectsofLongTermCultureonHumanEmbryonicStemCellAging.StemCellsDev.2011;20(1):127-38.Link(IF,4.8)
16.S,HuangM,LiZ,JiaF,GhoshZ,LijkwanM,SunN,FasanaroP,WangX,MartelliR,RobbinsRC,WuJC.MicroRNA-210asaNovelTherapyforTreatmentofIschemicHeartDisease.Circulation.2010,122:S124-S131.Link.(IF,14.8)
17.WilsonKD,SunN,HuangM,ZhangWY,LeeAJ,LiZ,WangSX,WuJC.EffectsofIonizingRadiationonSelfRenewalandPluripotencyofHumanEmbryonicStemCells.CancerResearch.2010,70(13):5539-48.Link(IF,8.2)
18.HuangNF,NiiyamaH,PeterC,DeA,NatkunamY,FleissnerFA,LiZ,RollinsM,WuJC,GambhirSS,CookeJP.EmbryonicStemCell-DerivedEndothelialCellsIncorporateintotheIschemicHindlimbandRestorePerfusion.Arteriosclerosis,Thrombosis,andVascularBiology.2010,30:915-922.Link(IF,7.2)
19.JiaF,WilsonKD,SunN,GuptaDM,HuangM,LiZ,KayMA,LongakerMT,WuJC.ASimpleNon-viralMinicircleVectorforDerivingHumaniPSCells.NatureMethods.2010,7(3):197-199.Link.(IF,20.7)
20.DaadiDM,DavisA,AracA,LiZ,MaagAL,BatnagarR,SunG,WuJC,SteinbergGK.HumanNeuralStemCellGraftsModifyMicroglialResponseandEnhanceAxonalSproutingInNeonatalHypoxic-IschemicBrainInjury.Stroke.2010,41(3):516-23.Link(IF,7.0)(selectedbyF1000)
21.WilsonKD,SmithB,KraftD,JiaF,XieX,HuangM,HoytG,ChuP,RobbinsRC,WeissmanIL,GambhirSS,WuJC.FunctionalandTranscriptionalCharacterizationofHumanEmbryonicStemCell-DerivedEndothelialCellsforTreatmentofMyocardialInfarction.PLoSONE.2009,4(12):e8443.Link(IF,4.4)
22.J,HuangNF,WilsonKD,VelottaJB,HuangM,LiZ,RobbinsRR,CookeJP,WuJC.nAChRsMediateHumanEmbryonicStemCell-DerivedEndothelialCells:Proliferation,Apoptosis,andAngiogenesis.PLoSONE.2009,4(9):e7040.Link(IF,4.4)
23.HuangM,ChenZY,JiaF,LiZ,KayMA,WuJC.Novelminicirclevectorforcellbasedgenetherapyinmurinemyocardialinfarction.Circulation.2009,120:S230-S237Link(IF,14.8)
24.DaadiDM,LiZ,AracA,GrueterBA,SofilosM,MalenkaRC,WuJC,SteinbergGK.MolecularandMagneticResonanceImagingofHumanEmbryonicStemCell-DerivedNeuralStemCellGraftsinIschemicRatBrain.MolecularTherapy.2009,17(7):1282–1291.Link.(IF,7.1)
25.LeeA,HuangM,ChungJ,ChuP,YangP,RosenbergJ,RobbinsRC,WuJC.ImagingSurvivalandFunctionofTransplantedCardiacStemCells.JournaloftheAmericanCollegeofCardiology.2009,53(14):1229–40.Link(IF,14.3)
26,HanZ,WuJC*.TransplantationofHumanEmbryonicStemCell-DerivedEndothelialCellsforVascularDiseases.JofCellBiochem.2009,106:194-199.(Journalcover,invitedreview)Link(IF,3.5)
27.XieX,ChanKS,CaoF,HangM,LiZ,LeeA,WeissmanI,WuJC.ImagingofSTAT3SignalingPathwayDuringMouseEmbryonicStemCellDifferentiation.StemCellandDevelopment.2009;18(2):205-14.Link(IF,4.8)
28.HuangM,ChanD,JiaF,XieX,LiZ,RobbinsRC,ChenX,GiacciaA,WuJC.ShortHairpinRNAInterferenceTherapyforIschemicHeartDisease.Circulation.2008;118:s226-233.Link(IF,14.8)
29.#WilsonKD,#LiZ,WagerR,YueP,TsaoP,NestorovaG,HuangM,HirschbergD,YockPG,QuertermousD,WuJC.Transcriptomealterationinthediabeticheartbyrosiglitazone:Implicationsforcardiovascularmortality.PLoSONE.2008,3(7):e2609.(#Co-firstauthor)Link(IF,4.4)
30.SuzukiY,HuangM,CaoF,XieX,ConnollyAJ,YangPC,WuJC.Comparisonofreportergeneandironparticlelabelingfortrackingfateofhumanembryonicstemcellsanddifferentiatedendothelialcellsinlivingsubjects.StemCells.2008,26(4):864-873.Link(IF,7.9)
31WuJC,SheikhAY,KraftD,CaoF,XieXY,PatelM,GambhirSS,RobbinsRC,CookeJP,WuJC.Differentiation,survival,andfunctionofembryonicstemcellderivedendothelialcellsforischemicheartdisease.Circulation.2007;116:I46-I54.Link(IF,14.4)
32.XieX,CaoF,SheikhAY,LiZ,ConnollyAJ,PeiX,LiRK,RobbinsRC,WuJC.GeneticmodificationofembryonicstemcellswithVEGFenhancescellsurvivalandimprovescardiacfunction.CloningandStemCells.2007;9(4):553-567Link(IF,2.9)
33.CaoF,DrukkerM,LinS,SheikhAY,XieX,LiZ,ConnollyAJ,WeissmanIL,WuJC..Molecularimagingofembryonicstemcellmisbehaviorandsuicidegeneablation.CloningandStemCells.2007;9(1):107-17.Link(IF,2.9)
34.LinS,XieX,PatelMR,YangYH,LiZ,CaoF,GheysensO,ZhangY,GambhirSS,RaoJH,WuJC.Quantumdotimagingforembryonicstemcells.BMCBiotechnol.2007;7(1):67Link(FeaturedinNanowerk).(IF,2.9)
35.ChangGY,CaoF,KrishnanM,HuangM,LiZ,XieX,SheikhAY,HoytG,RobbinsRC,HsiaiT,SchneiderMD,WuJC.Positronemissiontomographyimagingofconditionalgeneactivationintheheart.JMolCellCardiol.2007;43(1):18-26.(Journalcover)Link(IF,5.5)
著作:
1.YizhouZheng,DelingKongandZongjinLi*(2011).Non-invasiveImagingofHumanEmbryonicStemCellsDerivedEndothelialCellsUsingReporterGenes,MethodologicalAdvancesintheCulture,ManipulationandUtilizationofEmbryonicStemCellsforBasicandPracticalApplications,CraigAtwood(Ed.),ISBN:978-953-307-197-8,InTech,(*correspondenceauthor)Link
2.HuS,LavinghousezP,LiZ,WuJC(2011).DifferentiationofendothelialcellsfromhEScellsandhiPScells,HumanEmbryonicandInducedPluripotentStemCells,Ye,Kaiming;Jin,Sha(Eds.)ISBN978-1-61779-266-3,HumanaPress.Link
3.TongL,ZhaoH,HeZ,LiZ(2012).CurrentPerspectivesonMolecularImagingforTrackingStemCellTherapy"MedicalImaginginClinicalPractice",ErondoOF(Eds)ISBNInTech.
