簡介
臧敬五主要成果：
臧敬五教授的研究是立足於從臨床問題中提煉出關鍵免疫學科學問題，用最新的科學手段在分子和細胞水平上進行研究，並致力於成果的臨床套用。
一、通過對髓鞘抗原自身反應T細胞的研究，揭示了其在體內激活的可能機理及在多發性硬化炎症和中樞神經系統脫髓鞘病理過程中的關鍵作用。
二、首創用滅活髓鞘抗原反應T細胞治療多發性硬化(T細胞疫苗)。初步闡明了其體內免疫調節機理，並正在探索T細胞疫苗在多發性硬化和類風濕關節炎免疫治療中的臨床套用前景，研製T細胞受體多肽治療性疫苗。
主要論文、著作
近三年代表性論文：
JingwuZhang.YinandYanginterplayofIFN-gammaininflammationandautoimmunedisease.JournalofClinicalInvestigation2007,inpress
GuangjieChen,NingliLi,YingC.Q.Zang,DongqingZhang,DongyiHe,GuozhangFeng,LiqingNi,RongXu,LiWang,BaihuaShen,JingwuZhang.VaccinationWithSelectedSynovialTCellsinRheumatoidArthritis.ArthritisandRheumatism56(2),453-463,2007.
*ThispaperisaccompaniedwithanEditorialpublishedinthesameissue:
BrentPrakkenandSalvatoireAlbani.ExploitingTcellcrosstalkasavaccinationstrategyforrheumatoidarthritis.ArthritisandRheumatism56,389-392,2007
ZhaojunWang,JianHong,WeiSun,GuangwuXu,NingliLi,XiChen,AilianLiu,LingyunXu,BingSun,JingwuZhang.Roleofg-InterferoninInductionofFoxp3andConversionofCD4+CD25-TcellstoCD4+RegulatoryTCells.JournalofClinicalInvestigation.2006Sep1;116(9):2434-2441.
BingWan,HongNie,AilianLiu,GuozhangFeng,DongyiHe,RongXu,QiZhang,ChenDong,JingwuZhang.AberrantRegulationofSynovialTCellActivationbySolubleCo-StimulatoryMoleculesinRheumatoidArthritis.JournalofImmunology177(12):8844-8850,2006.
GuilinYang,AilianLiu,QingXie,TaylorB.Guo,BingWan,BopingZhou,JingwuZhang.AssociationofCD4+CD25+Foxp3+RegulatoryTCellswithChronicActivityandViralClearanceinPatientswithHepatitisB.InternationalImmunology.2006Dec20;[Epubaheadofprint]
JianHong,YingZang,HongNieandJingwuZhang.CD4+RegulatoryTCellresponsesinducedbyTcellvaccinationinpatientswithmultiplesclerosis.ProceedingsofNationalAcademyofScienceUSA103:5024-5029,2006
GuangwuXu,HongNie,NingliLi,WenxinZheng,DongqingZhang,GuozhangFeng,LiqingNi,RongXu,JianHong,JingwuZhang.Roleofosteopontininamplificationandperpetuationofrheumatoidsynovitis.JournalofClinicalInvestigation115(4):1060-1067,2005
JianHong,NingliLi,XuejunZhang,BiaoZheng,JingwuZhang.InductionofExpressionofTranscriptionFactorFoxP3andFunctionofCD4+CD25+RegulatoryTCells.ProceedingsofNationalAcademyofScienceUSA102(18):6449-6454,2005
GuangwuXu,WeiSun,DongyiHe,LiWang,WenxinZheng,HongNie,LiqingNi,DongqingZhang,NingliLi,JingwuZhang.Overexpressionofosteopontininrheumatoidsynovialmononuclearcellsisassociatedwithjointinflammation,notwithgeneticpolymorphism.JournalofRheumatology32:410-416,2005
WeiSun,HongNie,NingliLi,YingZang,DongqingZhang,GuozhangFeng,LiqingNi,RongXu,SarvamangalaPrasad,RachelRRobinson,WalterHo,EliSercarz,JingwuZhang.SkewedT-cellreceptorBV14andBV16expressionandsharedCDR3sequenceandcommonsequencemotifsinsynovialTcellsofrheumatoidarthritis.GenesandImmunity6:248-261,2005
