華國強[復旦大學研究員]

復旦大學放射醫學研究所研究員，研究生導師，中共黨員；2008年畢業於中國科學院生物物理研究所博士，2009-2015年美國紀念斯隆凱特琳癌症研究所（MemorialSloan Kettering Cancer Center）博士後從事幹細胞類器官和幹細胞輻射損傷再生研究。2014年受聘復旦大學放射醫學研究所研究員，組建幹細胞與再生醫學實驗室。

研究方向

1: 腸癌類器官為基礎的個性化精準治療；

2：類器官為基礎的高通量再生藥物篩選；

3: 腸道幹細胞在腸道上皮損傷再生修復中的作用；

論文成果

Hua,Guoqiang，Wang, Chu，Pan, Yan，Zeng,Zhaoshi，Lee, Sang Gyu，Martin,Maria Laura，Haimovitz-Friedman, Adriana，Fuks,Zvi，Paty, Philip B，Kolesnick,Richard N，Distinct levels of radioresistance inLgr5+ colonic epithelial stem cells versus Lgr5+ small intestinal stem cells.，Cancer Res. 2017 Apr 15;77(8):2124-2133.

Hua Guoqiang, Thin TH, Feldman R, Haimovitz-Friedman A, Clevers H, Fuks Z, Kolesnick R. Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant. Gastroenterology. 2012;143:1266–1276.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MR, Hanash AM. Interleukin-22 promotes intestinal stem cell mediated epithelial regeneration. Nature. 2015 Dec 24;528(7583):560-4

Hanash AM, Dudakov JA, Hua Guoqiang, et al. Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease. Immunity. 2012 Aug 24; 37(2): 339-50.

Rotolo J, Stancevic B, Zhang J, Hua Guoqiang, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R. Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice. J Clin Invest. 2012 May 1;122(5):1786-9.

Guoqiang Hua, Qixiang Zhang, and Zusen Fan. Heat Shock Protein 75 (TRAP1) Antagonizes Reactive Oxygen Species Generation and Protects Cells from Granzyme M-mediated Apoptosis. J. Biol. Chem., Jul 2007; 282: 20553 – 20560.

Guoqiang Hua, Wang S, Zhong C, Xue P, Fan Z; Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. J Immunol. 2009 Feb 15;182(4):2152-9.

Lianfeng Wu, Wang L, Guoqiang Hua, Liu K, Yang X, Zhai Y, Bartlam M, Sun F, Fan Z; Structural basis for proteolytic specificity of the human apoptosis-inducing granzyme M. J Immunol. 2009 Jul 1;183(1):421-9.

Tongbiao Zhao, Honglian Zhang, Yuming Guo, Qixiang Zhang, Guoqiang Hua, Hongxia Lu, Qiang Hou, Haiping Liu, and Zusen Fan. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death Differ, Mar 2007; 14(3): 489-99.