人物簡介
1985年畢業於中國科技大學生物系,
1988年在該校獲碩士學位。
1990年赴美,以聯合培養方式先後在加州大學聖地亞哥分校病理系及德州大學聖安東尼奧健康科學中心生物技術研究所進行四年博士論文工作,從事腫瘤抑制蛋白Rb功能的研究。
1995年在中國科技大學生物系任講師,同年在中科院上海細胞所獲博士學位,並成為上海生命科學研究中心的博士後兼課題組長。
1997年被聘為研究組長,副研究員,
1999年晉升研究員,博士生導師。同年轉入中科院上海生命科學研究院生化與細胞所。
2001年3月至8月在加州大學伯克利分校進行訪問研究。
2001年獲國家傑出青年基金支持。
現任生化細胞所副所長,所學術委員會主任,兼任中科院分子細胞生物學重點實驗室主任,《細胞生物學雜誌》副主編,《生物化學與生物物理學報》、《實驗細胞學報》、《Cell Research》編委,中國細胞生物學會副理事長,全國膜與細胞生物物理專業委員會委員、中國生物化學與分子生物學會常務理事等職。
獲獎情況
朱學良研究員於2000年獲得國家傑出青年基金,2004年獲中華人民共和國人事部“新世紀百千萬人才工程國家級人選”, 2006年被評為中科院研究生院優秀教師,2007年獲得中科院“優秀研究生指導教師”獎,2008年獲得上海市科委“學科帶頭人計畫”榮譽證書,2009年獲得上海市“自然科學牡丹獎”。2004年作為學術帶頭人獲得國家自然科學基金委“優秀創新群體”資助,2007年獲得了第二期的持續資助。2007年作為中科院生化細胞所承擔的中國科學院“海外創新群體”基金的中方召集人。
代表性論文
Du J, Li Y, Zhu X*(2010). Involvement of CENP-F in histone methylation. Acta Biochim Biophys Sin. 42(3):173-6.
Du J, Zhang Y, Liu Y, Li Y, and Zhu X*(2010). Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase. Acta Biochim Biophys Sin. 42: 839–846.
Yan X, Shen Y,Zhu X * (2010). Live Show of Rho GTPases in Cell Migration. J Mol Cell Biol., 2: 68–69.
Zhu X * (2010).Seeing the Yin and Yang in Cell Biology. Mol Biol Cell., 21: 3827–3828.
Ding C, Liang X, Ma L, Yuan X and Zhu X*. (2009) Opposed effect of Ndel1 and alpha1/2 on cytoplasmic dynein functions through competitive binding to Lis1. J Cell Sci. 122, 2820-2827.
Zhang Q, Wang F, Cao J, Shen Y, Huang Q, Bao L and Zhu X*. (2009) Nudel promotes axonal lysosome clearance and endo-lysosome formation via dynein-mediated transport. Traffic. 10:1337-1349.
Shan Y, Yu L, Li Y, Pan Y, Zhang Q, Wang F, Chen J, and Zhu X* (2009). Nudel and FAK as antagonizing strength modulators of nascent adhesions through Paxillin. PLoS Biol. 7(5): e1000116. doi:10.1371/journal.pbio.1000116.
Ma L, Tsai M-Y, Wang S, Lu B, Chen R, Yates III JR, Zhu X*, and Zheng Y *(2009). Requirement for Nudel and dynein for assembly of the lamin B spindle matrix. Nat. Cell Biol., 11: 247-256.
Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X*. (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev. Cell, 14, 342-353.
Wang F, Zhang Q, Cao J, Huang Q, Zhu X*. (2008) The microtubule plus end-binding protein EB1 is involved in Sertoli cell plasticity in testicular seminiferous tubules. Exp. Cell Res. 314, 213-226.
Li Y, Yu W, Liang Y, Zhu X*. (2007) Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment. Cell Res. 17, 701-712.
Liang Y, Yu W, Li Y, Yu L, Zhang Q, Wang F, Yang Z, Du J, Huang Q, Yao X, and Zhu X*. (2007) Nudel modulates kinetochore association and function of cytoplasmic dynein in M phase. Mol. Biol. Cell. 18, 2656-2666.
Guo J, Yang Z, Song W, Chen Q, Wang F, Zhang Q, and Zhu X*. (2006) Nudel contributes to MT anchoring at the mother centriole and is involved in both dynein-dependent and independent centrosomal protein assembly. Mol. Biol. Cell. 17:680-9.
Yang Z, Guo J, Chen Q, Du J, Ding C, and Zhu X*. (2005) Silencing mitosin induces misaligned chromosomes, premature chromosome decondensation before anaphase onset, and mitotic cell death. Mol. Cell. Biol. 25, 4062-74.
Zhou X, Wang R, Fan L, Li Y, Ma L, Yang Z, Yu W, Jing N, and Zhu X*. (2005) Mitosin/CENP-F as a negative regulator of activating transcription factor-4. J. Biol. Chem. 280, 13973-7.
Liang Y, Yu W, Li Y, Yang Z, Yan X, Huang Q, and Zhu X*. (2004) Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein. J. Cell Biol. 164, 557-566.
Yang Z, Guo J, Li N, Qian M, Wang S, Zhu X*. (2003) Mitosin/CENP-F is a conserved kinetochore protein subjected to cytoplasmic dynein-mediated poleward transport. Cell Res. 13, 275-283.
Fan L, Yu W, Zhu X*. (2003) Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. 540, 77-80.
Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and Zhu X*. (2003) Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic Spindle. Mol. Cell. Biol. 23, 1239-50.
Zhao X, Yang Z, Qian M, and Zhu X*. (2001) Interaction among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem. Biophy. Res. Commun. 280, 513-517.
Yan X., Zhao X, Qian M, Guo N, Gong X, and Zhu X*. (2000) Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem. J. 345, 749-757.
Zhu X*. (1999) Structural requirements and dynamics of mitosin-kinetochore interaction in M phase. Mol. Cell. Biol. 19, 1016-1024.