簡介
候筱宇候筱宇
侯筱宇，女，1970年4月出生，博士，現任徐州醫學院基礎醫學部生物化學教研室副主任、生物化學與分子生物學研究中心副主任、徐州醫學院腦病信號轉導與蛋白質組學重點實驗室副主任，省級重點學科學術帶頭人，副教授，碩士生導師。中國藥科大學藥物分析專業本科生，獲理學學士學位。江蘇省徐州醫藥中等專科學校任教。徐州醫學院生物化學與分子生物學專業碩士研究生，獲理學碩士學位。中國科學院上海藥物研究所神經藥理學專業博士研究生，獲理學博士學位。榮獲2004年度省優秀青年科學家提名獎、省“333工程第三成次培養對象、省高校“青藍工程”優秀青年骨幹教師培養對象。榮獲第十屆“徐州市十大傑出青年”稱號。現任生物化學教研室副主任、省腦病生物信息重點實驗室主任，主持1項國家自然科學基金資助項目、省級科研課題2項，獲教育部新世紀優秀人才支持計畫資助，已發表SCI收錄15篇。
研究方向
主要從事缺血性腦中風分子機制及其防治的研究。先後主持了國家級和部省級項目，並參加了多項國家級和部省級項目的研究。主要研究成果：(1)系統的研究了海馬、紋狀體腦區在缺血時堆積的大量多巴胺與鈣調素蛋白激酶Ⅱ活性抑制的關係，闡明了缺血時多巴胺參與鈣調素蛋白激酶Ⅱ活性的抑制作用，多巴胺受體（包括D1和D2樣受體）介導了酶活性的抑制。經江蘇省科學技術情報研究所查新中心所出示的查新報告表明：國內外均無同類報導。經專家鑑定，達“國內領先和國際先進水平”。(2)系統的研究了腦缺血後兩種鈣通道―NMDA受體和L-型電壓門控鈣通道在酪氨酸水平上的調控機制。繪製了完整的腦缺血兩種鈣通道相互對話的信號轉導通路圖，發表於BrainResearch。在此研究過程中，發現了腳手架蛋白PSD-95新的調控機制及其可能的相互作用蛋白質，因此先後獲國家自然科學基金委員會和教育部的資助。(3)發現一種中草藥提取物SY-21具有抑制鈣通道酪氨酸磷酸化的藥理作用，具有水溶性、在缺血後用藥仍有顯著的神經保護作用等特點，大有進一步研製開發的前景。發表論文17篇，其中13篇被SCI收錄。獲江蘇省科技進步三等獎一項。先後榮獲“徐州市首屆青年科技獎”、“江蘇省高校‘青藍工程’優秀青年骨幹教師”、“江蘇省‘333工程’第三層次培養對象”、“江蘇省青年科學家獎”(提名獎)。
代表性論文
1. Currentrectificationintemperature-responsivesinglenanopores.
GuoW,XiaH,XiaF,HouX,CaoL,WangL,XueJ,ZhangG,SongY,ZhuD,WangY,JiangL.
Chemphyschem.2010Mar15;11(4):859-64.PMID:20140936[PubMed-inprocess]Relatedarticles
2.
OverexpressionofthePDZ1domainofPSD-95diminishesischemicbraininjuryviainhibitionoftheGluR6.PSD-95.MLK3pathway.
HuSQ,ZhuJ,PeiDS,zongYY,YanJZ,HouXY,ZhangGY.
JNeurosciRes.2009Dec;87(16):3626-38.PMID:19610093[PubMed-indexedforMEDLINE]Relatedarticles
3.
[Recombinantadeno-associatedvirusmediatedRNAinterferenceofangiogeninexpressioninhibitscellgrowthofhumanlungadenocarcinoma]
LiBL,ZhangGX,HouXL,TanMW,YuanY,LiuXH,GongDJ,HuangSD.
ZhonghuaJieHeHeHuXiZaZhi.2009Mar;32(3):188-92.Chinese.PMID:19575937[PubMed-inprocess]Relatedarticles
4.
Neuroprotectionagainsttransientfocalcerebralischemiaandoxygen-glucosedeprivationbyinterferencewithGluR6-PSD95proteininteraction.
YuCZ,LiC,PeiDS,ZongYY,ShiQ,WenXR,GuanQH,HangD,HouXY,ZhangGY.
NeurochemRes.2009Nov;34(11):2008-21.Epub2009May18.PMID:19449206[PubMed-indexedforMEDLINE]Relatedarticles
5.
GluR6-containingKAreceptormediatestheactivationofp38MAPkinaseinrathippocampalCA1regionduringbrainischemiainjury.
ChenJ,LiC,PeiDS,HanD,LiuXM,JiangHX,WangXT,GuanQH,WenXR,HouXY,ZhangGY.
Hippocampus.2009Jan;19(1):79-89.PMID:18680160[PubMed-indexedforMEDLINE]Relatedarticles
6.
[prevalenceofcoronaryarterydiseaseinpatientswithrheumaticheartdiseaseinChina]
LiBL,LiL,HouXL,HeB,ZhangGX,ChenKB,XuZY.
ZhonghuaYiXueZaZhi.2007Dec18;87(47):3313-6.Chinese.PMID:18478941[PubMed-indexedforMEDLINE]Relatedarticles
7.
[EffectsofXuefuZhuyuCapsuleonendothelin-1releaseinmyocardiumandvascularendotheliumandnitricoxide/nitricoxidesynthasesystemofswinesafteracutemyocardialinfarctionandreperfusion]
HouXL,LiBL,ZhaoL,HuangSD,XuZY,ZhangGX.
ZhongXiYiJieHeXueBao.2008Apr;6(4):381-6.Chinese.PMID:18405606[PubMed-inprocess]RelatedarticlesFreearticle
8.
Simultaneousdeterminationofmalachitegreen,gentianvioletandtheirleuco-metabolitesinaquaticproductsbyhigh-performanceliquidchromatography-lineariontrapmassspectrometry.
WuX,ZhangG,WuY,HouX,YuanZ.
JChromatogrA.2007Nov23;1172(2):121-6.Epub2007Aug7.PMID:17950300[PubMed-indexedforMEDLINE]Relatedarticles
9.
PP2,apotentinhibitorofSrcfamilykinases,protectsagainsthippocampalCA1pyramidalcelldeathaftertransientglobalbrainischemia.
HouXY,LiuY,ZhangGY.
NeurosciLett.2007Jun15;420(3):235-9.Epub2007Mar25.PMID:17556100[PubMed-indexedforMEDLINE]Relatedarticles
10.
Fabricationofacovalentlyattachedself-assemblymultilayerfilmbasedonCdTenanoparticles.
ZhangH,YangB,WangR,ZhangG,HouX,WuL.
JColloidInterfaceSci.2002Mar15;247(2):361-5.PMID:16290475[PubMed]Relatedarticles
11.
Suppressionofpostsynapticdensityprotein95byantisenseoligonucleotidesdiminishespostischemicpyramidalcelldeathinrathippocampalCA1subfield.
HouXY,ZhangGY,WangDG,GuanQH,YanJZ.
NeurosciLett.2005Sep16;385(3):230-3.PMID:15970382[PubMed-indexedforMEDLINE]Relatedarticles
12.
Proteomics-basedidentificationofDEAD-boxprotein48asanovelautoantigen,aprospectiveserummarkerforpancreaticcancer.
XiaQ,KongXT,ZhangGA,HouXJ,QiangH,ZhongRQ.
BiochemBiophysResCommun.2005May6;330(2):526-32.PMID:15796914[PubMed-indexedforMEDLINE]Relatedarticles
13.
ActivationandinvolvementofJNK1/2inhydrogenperoxide-inducedneurotoxicityinculturedratcorticalneurons.
WangW,GaoC,HouXY,LiuY,ZongYY,ZhangGY.
ActaPharmacolSin.2004May;25(5):630-6.PMID:15132830[PubMed-indexedforMEDLINE]RelatedarticlesFreearticle
14.
[RegulationofneuronalL-typevoltage-gatedcalciumchannelsandbrainischemia]
HouXY,ZhangGY.
ShengLiKeXueJinZhan.2004Jan;35(1):77-80.Review.Chinese.Noabstractavailable.PMID:15127607[PubMed-indexedforMEDLINE]Relatedarticles
15.
Regulationofc-JunN-terminalkinaseactivationinhydrogenperoxideinducedneurotoxicity.
WangW,HouXY,GaoC,LiuY,ZongYY,ZhangGY.
JNeurocytol.2003Feb;32(2):143-51.PMID:14707549[PubMed-indexedforMEDLINE]Relatedarticles
16.
PossiblemechanismsunderlyingtheprotectiveeffectsofSY-21,anextractofatraditionalChineseherb,ontransientbrainischemia/reperfusion-inducedneuronaldeathinrathippocampus.
ChenM,WangY,LiuY,HouXY,ZhangQG,MengFJ,ZhangGY.
BrainRes.2003Nov7;989(2):180-6.PMID:14556939[PubMed-indexedforMEDLINE]Relatedarticles
17.
Twotypesofcalciumchannelsregulatingactivationofproline-richtyrosinekinase2inducedbytransientbrainischemiainrathippocampus.
LiuY,ZhangGY,HouXY,XuTL.
NeurosciLett.2003Sep18;348(3):127-30.PMID:12932810[PubMed-indexedforMEDLINE]Relatedarticles
18.
Increasedtyrosinephosphorylationofalpha(1C)subunitsofL-typevoltage-gatedcalciumchannelsandinteractionsamongSrc/Fyn,PSD-95andalpha(1C)inrathippocampusaftertransientbrainischemia.
HouXY,ZhangGY,YanJZ,LiuY.
BrainRes.2003Jul25;979(1-2):43-50.PMID:12850569[PubMed-indexedforMEDLINE]Relatedarticles
19.
Suppressionofpostsynapticdensityprotein95expressionattenuatesincreasedtyrosinephosphorylationofNR2AsubunitsofN-methyl-D-aspartatereceptorsandinteractionsofSrcandFynwithNR2Aaftertransientbrainischemiainrathippocampus.
HouXY,ZhangGY,ZongYY.
NeurosciLett.2003Jun5;343(2):125-8.PMID:12759180[PubMed-indexedforMEDLINE]Relatedarticles
20.
L-typevoltage-gatedcalciumchannelattendsregulationoftyrosinephosphorylationofNMDAreceptorsubunit2Ainducedbytransientbrainischemia.
LiuY,HouXY,ZhangGY,XuTL.
BrainRes.2003May16;972(1-2):142-8.PMID:12711087[PubMed-indexedforMEDLINE]Relatedarticles
21.
TyrosinekinaseandtyrosinephosphataseparticipateinregulationofinteractionsofNMDAreceptorsubunit2AwithSrcandFynmediatedbyPSD-95aftertransientbrainischemia.
ChenM,HouX,ZhangG.
NeurosciLett.2003Mar13;339(1):29-32.PMID:12618293[PubMed-indexedforMEDLINE]Relatedarticles
22.
[Mechanismsunderlyingdopaminergicneurotoxicityinischemiccerebraldamage]
HouXY,ZhangGY.
ShengLiKeXueJinZhan.1999Oct;30(4):315-20.Review.Chinese.PMID:12532824[PubMed-inprocess]Relatedarticles
23.
ActivationofNMDAreceptorsandL-typevoltage-gatedcalciumchannelsmediatesenhancedformationofFyn-PSD95-NR2Acomplexaftertransientbrainischemia.
HouXY,ZhangGY,YanJZ,ChenM,LiuY.
BrainRes.2002Nov15;955(1-2):123-32.PMID:12419528[PubMed-indexedforMEDLINE]Relatedarticles
24.
StimulationofdopaminereceptorsinhibitedCa2+-calmodulin-dependentproteinkinaseIIactivityinratstriatalslices.
HouXY,TangFM,ZhangGY.
ActaPharmacolSin.2001Nov;22(11):966-70.PMID:11749784[PubMed-indexedforMEDLINE]RelatedarticlesFreearticle
25.
NMDAreceptoractivationresultsintyrosinephosphorylationofNMDAreceptorsubunit2A(NR2A)andinteractionofPyk2andSrcwithNR2Aaftertransientcerebralischemiaandreperfusion.
LiuY,ZhangG,GaoC,HouX.
BrainRes.2001Aug3;909(1-2):51-8.PMID:11478920[PubMed-indexedforMEDLINE]Relatedarticles
26.
InhibitoryeffectofdopamineonCa(2+)-calmodulin-dependentproteinkinaseIIactivityinrathippocampalslices.
HouXY,ZhangGY.
ZhongguoYaoLiXueBao.1999Oct;20(10):902-6.PMID:11270989[PubMed-indexedforMEDLINE]RelatedarticlesFreearticle
27.
Protectionofdopaminergicantagonistsagainstanoxia-inducedinhibitionofCa(2+)-calmodulindependentproteinkinaseIIactivityinratbrain.
HouXY,ZhangGY.
ZhongguoYaoLiXueBao.1999Nov;20(11):995-9.PMID:11270981[PubMed-indexedforMEDLINE]RelatedarticlesFreearticle
