簡介
師從卓仁禧院士。先後在新加坡生命醫學中心、約翰·霍普金斯大學醫學院生物醫學工程系從事研究工作。2004年12月，入選中國科學院“引進國外傑出人才”。
研究方向
1.生物醫用高分子材料；
2·蛋白質和核酸的高分子傳遞體系；
3·基因治療和組織工程。
研究課題
1·聚磷酸酯高分子生物材料的合成方法學及性能評價；
2·生物可降解納米材料的製備及其細胞轉運調節和機制；
3·可注射生物可降解高分子水凝膠的製備及生物醫用；
4·藥物控制釋放及靶向輸送載體的構建及生物學功效；
5·RNA干擾及siRNA藥物靶向輸送及關鍵技術；
6·癌症基因治療新型傳輸載體、細胞轉運機制及功效；
7·組織工程“人工骨”支架材料及組織工程新方法。
獲獎及榮譽
2001ControlledReleaseSociety-CapsugelAwardonInnovativeAspectsofGastrointestinalDrugAbsorptionandDelivery,ControlledReleaseSociety
論文及專著
1.XiaoCS,WangYC,DuJZ,ChenXS,WangJ*,KineticsandMechanismof2-Ethoxy-2-oxo-1,3,2-dioxaphospholanePolymerizationInitiatedbyStannousOctoate,MACROMOLECULES2006,inpress
2.DuJZ,ChenDP,WangYC,XiaoCS,LuYJ,WangJ*,ZhangGZ,SynthesisandMicellizationofAmphiphilicBrush-CoilBlockCopolymerBasedonPoly(ε-caprolactone)andPEGylatedPolyphosphoester,BIOMACROMOLECULES2006,7(6):1898-1963
3.ChenDP,WangJ*,Synthesisandcharacterizationofblockcopolymerofpolyphosphoesterandpoly(epsilon-caprolactone),MACROMOLECULES2006,39(2):473-475
4.LiQ,WangJ,ShahaniS,SunDDN,SharmaB,ElisseeffJH,LeongKW,Biodegradableandphotocrosslinkablepolyphosphoesterhydrogel,BIOMATERIALS2006,27(7):1027-1034
5.ZouJH,ShiWF,WangJ,JunB,Encapsulationandcontrolledreleaseofahydrophobicdrugusinganovelnanoparticle-forminghyperbranchedpolyester,MACROMOLECULARBIOSCIENCE2005,5(7):662-668
6.ZhangPC,WangJ,LeongKW,MaoHQ,Ternarycomplexescomprisingpolyphosphoramidategenecarrierswithdifferenttypesofchargegroupsimprovetransfectionefficiency,BIOMACROMOLECULES2005,6(1):54-60
7.WanACA,MaoHQ,WangS,PhuaSH,LeeGP,PanJS,LuS,WangJ,LeongKW,Poly(phosphoester)ionomersastissue-engineeringscaffolds,JOURNALOFBIOMEDICALMATERIALSRESEARCHPARTB-APPLIEDBIOMATERIALS2004,70B(1):91-102
8.WangJ,LeeIL,LimWS,ChiaSM,YuH,LeongKW,MaoHQ,Evaluationofcollagenandmethylatedcollagenasgenecarriers,INTERNATIONALJOURNALOFPHARMACEUTICS2004,279(1-2):115-126
9.WangJ,GaoSJ,ZhangPC,WangS,MaoMQ,LeongKW,Polyphosphoramidategenecarriers:effectofchargegroupongenetransferefficiency,GENETHERAPY2004,11(12):1001-1010
10.HuangSW,WangJ,ZhangPC,MaoHQ,ZhuoRX,LeongKW,Water-solubleandnonionicpolyphosphoester:Synthesis,degradation,biocompatibilityandenhancementofgeneexpressioninmousemuscle,BIOMACROMOLECULES2004,5(2):306-311
11.WangJ,SunDDN,Shin-yaY,LeongKW,Stimuli-responsivehydrogelbasedonpoly(propylenephosphate),MACROMOLECULES2004,37(2):670-672
12.LiQ,WilliamsCG,SunDDN,WangJ,LeongK,ElisseeffJH,Photocrosslinkablepolysaccharidesbasedonchondroitinsulfate,JOURNALOFBIOMEDICALMATERIALSRESEARCH2004,68A(1):28-33
13.LiY,WangJ,LeeCGL,WangCY,GaoSJ,TangGP,MaYX,YuH,MaoHQ,LeongKW,WangS,CNSgenetransfermediatedbyanovelcontrolledreleasesystembasedonDNAcomplexesofdegradablepolycationPPE-EA:acomparisonwithpolyethylenimine/DNAcomplexes,GENETHERAPY2004,11(1):109-114
14.LuHF,LimWS,WangJ,TangZQ,ZhangPC,LeongKW,ChiaSM,YuH,MaoHQ,GalactosylatedPVDFmembranepromoteshepatocyteattachmentandfunctionalmaintenance,BIOMATERIALS2003,24(27):4893-4903
15.WangJ,HuangSW,ZhangPC,MaoHQ,LeongKW,Effectofside-chainstructuresongenetransferefficiencyofbiodegradablecationicpolyphosphoesters,INTERNATIONALJOURNALOFPHARMACEUTICS2003,265(1-2):75-84
16.FangN,WangJ,MaoHQ,LeongKW,ChanV,BHEM-Chol/DOPEliposomeinducedperturbationofphospholipidbilayer,COLLOIDSANDSURFACESB-BIOINTERFACES2003,29(4):233-245
17.ZhaoZ,WangJ,MaoHQ,LeongKW,PolyphosphoestersindrugandgenedeliveryADVANCEDDRUGDELIVERYREVIEWS2003,55(4):483-499
18.WangJ,ZhangPC,LuHF,MaN,WangS,MaoHQ,LeongKW,Newpolyphosphoramidatewithaspermidinesidechainasagenecarrier,JOURNALOFCONTROLLEDRELEASE2002,83(1):157-168
19.WangJ,ZhangPC,MaoHQ,LeongKW,EnhancedgeneexpressioninmousemusclebysustainedreleaseofplasmidDNAusingPPE-EAasacarrier,GENETHERAPY2002,9(18):1254-1261
20.WangJ,MaoHQ,LeongKW,Anovelbiodegradablegenecarrierbasedonpolyphosphoester,JOURNALOFTHEAMERICANCHEMICALSOCIETY2001,123(38):9480-9481
