廖明幟

Lian Lian Lian

學習經歷

2006年本科畢業於西北大學數學系
2011年博士畢業於哈爾濱醫科大學生物信息科學與技術學院

研究興趣

生物數據大爆炸的時代,帶給了科研人員新的嚴峻挑戰。我們將挖掘這些大數據背後的信息,包括基因組、轉錄組、蛋白質組以及它們相互之間的轉錄調控、轉錄後修飾等多層次信息。利用數學、計算機等知識工具開展計算系統生物學的研究,以其發現生物學新現象、新規律,為下游的生物學實驗驗證工作提供理論依據和指導意見。目前我們的研究焦點集中在:動物發育生物學分子機理。

主要學術成果

1、主持和參加的科研項目

國家自然科學基金(31301938),奶山羊精子發生過程相關microRNA分子作用通路的生物信息學挖掘分析
國家自然科學基金(30900837),惡性心律失常相關的 microRNA及其調控通路的識別
西北農林科技大學校博士啟動基金,共表達miRNA調控機制及功能的研究
西北農林科技大學生命學院科研實驗室項目,生物信息學實驗室建設
黑龍江省衛生廳(1153121),結腸癌相關基因的轉錄因子及其蛋白互作網路的關聯研究
黑龍江省教育廳(2009-2538),複雜疾病特異遺傳網路逆向重構算法的研究

2、近年發表論文

SCI論文(按時間順序):
Jiang Wu, Haijing Zhu, Wencong Song, Mingzhao Li, C Liu, Na Li, Furong Tang, Hailong Mu, Mingzhi Liao, X Li, and Jinlian Hua Identification of Conservative MicroRNAs in Saanen Dairy Goat Testis Through Deep Sequencing. Reproduction in Domestic Animals. 2013. ( SCI Impact factor: 1.392)
Guiyou Liu, Shuyan Zhang, You Li, Lili Cui, Guoda Ma, Yongshuai Jiang, Liangcai Zhang, Rennan Feng, Mingzhi Liao, and Zugen Chen, BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population. Neuroscience letters. 2013. ( SCI Impact factor: 2.026)
Lin Yang, Rennan Feng, Guiyou Liu, Mingzhi Liao, Liangcai Zhang, and Wenbo Wang, TNF-β+ 252 A> G polymorphism and susceptibility to cancer. Journal of cancer research and clinical oncology. p. 1-8. 2013. ( SCI Impact factor: 2.914)
Guiyou Liu, Lifen Yao, Guoda Ma, Liangcai Zhang, Yongshuai Jiang, Rennan Feng, Mingzhi Liao, Zugen Chen, Bin Zhao, Keshen Li, “PICALM gene rs3851179 polymorphism contributes to Alzheimer’s disease in Asian population”. Neuromolecular?Med, DOI: NEMM-D-13-00008, 2013.( SCI Impact factor: 5.0)
Mingzhi Liao, Rennan Feng, Gguiyou Liu, Lliangcai Zhang, “Comments on dietary intake of vitamin D during adolescence and risk of adult onset systemic lupus erythematosus and rheumatoid arthritis”. Arthritis Care & Research, DOI: 10.1002/acr.21840, 26 February, 2013.(SCI Impact factor: 4.851)
Wei Jiang, Xiaowen Chen, Mingzhi Liao*, Wei Li, Baofeng Lian, Lihong Wang, Fanlin Meng, Xinyi Liu,Xiujie Chen,Xia Li., "Identification of links between small molecules and miRNAs in human cancers based on transcriptional responses". Scientific Report, Volume 2,DOI: 10.1038/srep00282, 21 February, 2012.(SCI Impact factor:2.927,*co-first author)
Guiyou Liu, Liangcai Zhang, Rennan Feng, Mingzhi Liao, Yongshuai Jiang, Zugen Chen, Bin Zhao, Keshen Li, “Lack of association between PICALMrs3851179 polymorphism and Alzheimer’s disease in Chinese population andAPOEε4-negative subgroup”. Neurobiology of Aging, DOI:10.1016/j.neurobiolaging. October, 2012.(SCI Impact factor: 6.189)
Xia Li, Wei Jiang, Wei Li, Baofeng Lian, Shuyuan Wang, Mingzhi Liao, Xiaowen Chen, Yanqiu Wang, Yingli Lv, Shiyuan Wang, Lei Yang " Dissection of?human?MiRNA regulatory influence to?subpathway " BRIEF BIOINFORM, Volume 13, Issue 2, Pages 175-86, September 10, 2011.(SCI Impact factor:?9.283)
Yanqiu Wang, Xiaowen Chen, Wei Jiang, Li Li, Wei Li, Lei Yang, Mingzhi Liao, Baofeng Lian, Yingli Lv, Shiyuan Wang, Shuyuan Wang, and Xia Li "Predicting human microRNA precursors based on optimized feature subset generated by GA-SVM". Genomics, Volume 98, Issue 2, Pages 73-78, August , 2011 (SCI Impact factor:?3.327. )
Mingzhi Liao, Wei Jiang, Xiaowen Chen, Baofeng Lian, Wei Li, Yingli Lv, Yanqiu Wang, Shiyuan Wang, Xia Li, "Systematic analysis of regulation and functions of co-expressed microRNAs in humans," Molecular BioSystems, Volume 6, Pages 1863-1872, October, 2010.(SCI Impact factor:?4.015)
會議論文:
Shihua Zhang, Mingzhi Liao, Xia Li, "The modular property implied in the human disease gene network". The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. Start Page 58, Wuhan, June 4-6, 2010.
Shihua Zhang, Chao Wu, Xia Li, Mingzhi Liao, Yuqing Yan, "Sequence periodicity of human endogenous retroviruses". The 5th International Conference on Frontier of Computer Science and Technology - Workshop on Bioinformatics and System Biology. Start Page 47, Wuhan, June 4-6, 2010.
中文論文:
宿菲,吳超,徐建凱,廖明幟,張昀,劉寶全,“蛋白互作與基因共同控的關聯研究”. 國際遺傳學雜誌,35卷,2期, 2012.

3、獎勵

廖明幟,姜偉,陳曉文,李霞,Systematic analysis of regulation and functions of co-expressed microRNAs inhumans, 黑龍江省科學技術協會,黑龍江省自然科學技術學術成果獎二等獎,2011

相關詞條

熱門詞條

聯絡我們