尹慧勇

尹慧勇

"Assistan Peroxidation eider

個人簡介:

尹慧勇博士中科院脂肪酸代謝與營養相關疾病研究組組長
1992年本科畢業於上海同濟大學化學系,1995年在中科院上海有機化學研究所獲得碩士學位,2002年於美國范德堡大學(Vanderbilt University)化學系獲得博士學位。其後在美國范德堡大學醫學院臨床藥理部,醫學系,藥學系和化學系任研究助理教授(Research Assistant Professor, 2005)和研究副教授(Research Associate Professor, 2009)。2007至2009年擔任范德堡大學藥物開發項目藥代動力學中心實驗室主任。尹慧勇博士作為PI和Co-Investigator參與了多項美國國立衛生研究院(NIH)研究項目。2010年加入中國科學院上海生命科學研究院營養科學研究所,任研究員,博士生導師,研究組長。

研究領域:

(1) 利用化學、分子與細胞生物學、動物模型以及人體臨床實驗等手段研究內源性自由基以及氧化應激(Oxidative Stress)對不飽和脂肪酸代謝的調節與影響及其代謝產物在營養相關疾病中的作用;
(2) 研究和開發基於現代質譜技術的代謝組學(Metabolomics)、脂組學(Lipidomics)和蛋白組學(Proteomics) 等手段研究脂肪酸代謝與人類營養及疾病的關係;
(3) 研究利用營養干預預防和治療一些與脂肪酸代謝相關的疾病;
(4) 研究食品中化學污染物的毒性及致病機理;開發快速檢測食品有害化學污染物的手段。

近期論文:

Huiyong yin, Libin Xu, and Ned A Porter. Free Radical Lipid Peroxidation: Mechanisms and Analysis. Chem. Rev.2011, 111(10), 5944-5972.
Wei Liu, Claus Schneider, Alan brash, and Ned A Porter, Huiyong Yin*. Novel Chemical Mechanism Of 4-Hydroxynonenal (4-HNE) Formation: Cross-Chain Peroxyl Radical Addition And Decomposition In Phospholipids. Free Radic. Biol. Med., 2011. 50(1), 166-178.
Huiyong Yin*, Wei Liu, Kasia Goleniewsk, Ned A. Porter, Jason D. Morrow, Ryszard Dworski, R. Stokes Peebles, Jr. Dietary Supplementation of w-3 Fatty Acid-Containing Fish Oil Enhances Inflammatory Response in a Mouse Model of Ovalbumin-Induced Allergic Lung Inflammation. Free Radic. Biol. Med.2009, 47, 622-628.
Huiyong Yin*, Todd A. Davis, and Ned A. Porter. Simultaneous Analysis of Multiple Lipid Oxidation Products in vivo by Liquid Chromatographic-Mass Spectrometry (LC-MS). Methods Mol. Biol., 2009, 375-386.
Ming-Zhi Zhang, Jie Xu, Bing Yao, Huiyong Yin, Qiuyin Cai, Martha J. Shrubsole, Xiwu Chen, Valentina Kon, Wei Zheng, Ambra Pozzi, Raymond C. Harris. Inhibition of 11β hydroxysteroid dehydrogenase-2 selectively blocks the tumor cyclooxygenase-2 pathway and suppresses colon carcinogenesis. J. Clin. Invest., 2009, 119, 876-885.
Huiyong Yin*, Brian E. Cox, Ned A. Porter, Jason D. Morrow. Identification of Intact Oxidation Products of Glycerophospholipids Using Negative Ion Electrospray Iontrap Mass Spectrometry. J. Mass. Spectrom., 2009, 44, 672-680.
Ginger L. Milne, Huiyong Yin, and Jason D. Morrow. Human Biochemistry of the Isoprostane Pathways. J. Biol. Chem., 2008, 283, 15533-15537.
Huiyong Yin, Ling Gao, Ned A. Porter, Hsin-Hsiung Tai, Laine J. Murphey, and Jason D. Morrow. Prostaglandin PGF2a in Human Urine Is Generated from Non-enzymatic Free Radical Pathways. J. Biol. Chem.2007, 282, 329-336.
Huiyong Yin*, Douglass Masterson, Almary Chacon, Ned A Porter. Free radical-induced Site-Specific peptide cleavage in the gas phase of mass spectrometry. J. Am. Soc. Mass Spectrom., 2007, 18, 807-816.
Huiyong Yin, Christine M. Havrilla, Jason D. Morrow, and Ned A Porter. Formation of Isoprostane Bicyclic Endoperoxides from the Autoxidation of Cholesteryl Arachidonate. J. Am. Chem. Soc., 2002, 124, 7745-7754.

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