主要學習工作簡歷
副教授 2003，09 – 現在 遼寧師範大學 化 學化工學院
訪問教授 2005，01 – 2005，12 韓國梨花女子大學 藥學院（College of Pharmacy Ewha Womans University）
博士後 2001, 11 – 2003, 08 韓國化學研究院（Korea Research Institute of Chemical & Technology）
感染症治療劑研究中心
訪問研究員 2001, 03 – 2001, 10 韓國嶺南大學(Yeungnam University)附屬藥物開發研究所
藥學博士 1997, 03 – 2001, 02 韓國嶺南大學（Yeungnam University）藥學院 藥物化學專業
助教，講師 1993, 08 – 1997, 02 延邊大學 藥學院 有機化學教研室
碩士 1990, 09 – 1993, 07 延邊大學 化學系 有機化學專業
學士 1986, 09 – 1990, 07 延邊大學 化學系
教學工作
主要講授課程:
本科：藥物化學；藥物化學實驗；有機化學實驗
研究生：有機藥物合成原理 藥物化學研究
指導研究生情況：碩士研究生7人
主持科研項目
1． 參與韓國化學研究院(KRICT)與美國NIH下屬的全球結核病聯盟(GATB)合作開發的結核病治療劑前臨床及候選藥物合成的大型課題(Koreans Join TB Battle， Science, 2003, 300, 562)；參與多項韓國保健福址部、科技部和產資部課題。
2．主持留學歸國人員啟動基金和校項課題。
發表論文及專利
專利：
-Park T. H., Zhao L. X., Lee S. H., Process for Preparation of 2-Aminopyridine Derivatives, United States Patent Application Publication, US 2006/0047124 A1, 2006, Mar. 2; Korean Patent, 10-2006-0020082, 2006, Mar. 6.
近年來在期刊上發表的論文：
1. Pei X., Choi W. J., Kim Y. M., Zhao L. X. and Jeong L. S.; Synthesis of 3′-C-Hydroxymethyl-substituted Pyrimidine and Purine Nucleosides as Potential Anti-Hepatitis C Virus (HCV) Agents, Archives of Pharmacal Research, In Press, 2008
2.趙龍鉉，裴曉娟，劉寧寧，劉丹竹，王迪峰；熊果醛和齊墩果醛的合成及其表征，中國材料科技與設備，In Press, 2008
3. Son J. K., Zhao L. X., Basnet A. and Lee E. S.; Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities, European Journal of Medicinal Chemistry, 43(4), 675-682, 2008
5. Jeong L. S., Tosh D. K., Kim H. O., Wang T., Hou X., Yun H. S., Kwon Y., Lee S. K., Choi J., and Zhao L. X.; First Synthesis of 4′-Selenonucleosides Showing Unusual Southern Conformation, Org. Lett., 10(2),209-212, 2008
6. Hou X., Lee H. W., Tosh D. K., Zhao L. X. and Jeong L. X.; Alternative and Improved Syntheses of Highly Potent and Selective A3 Adenosine Receptor Agonists, Cl-IB-MECA and Thio-Cl-IB-MECA, Archives of Pharmacal Research， 30(10)，1205-1209， 2007
7.Wei C. X., Li F. N., Zhao L. X.and Quan Z. S.; Synthesis of 2-Substituted-7-heptyloxy-4,5-dihydro-[1,2,4]-triazolo[4,3- a]quinolin-1(2 H)-ones with
Anticonvulsant Activity, Arch. Pharm. Chem. Life Sci., 340, 491-495, 2007
8.趙龍鉉, 劉寧寧, 裴曉娟, 王迪峰, 劉丹竹; 熊國酸和齊墩果酸衍生物的合成與表征; 遼寧師範大學學報(自然科學版); 30(4), 476-479, 2007
9.Wang T., Lee H. J., Tosh D. K., Kim H. O., Pal S., Choi S., Lee Y., Moon H. R., Zhao L. X., Lee K. M. and Jeong L. S.; Design, synthesis, and
molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-
adenosylhomocysteine hydrolase, Bioorg . Med. Chem. Lett. 17，4456-4459, 2007
10. Zhao L. X., Park H. G., Jew S., Lee M. K. and Lee E. S.; Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and
Evaluation of Hepatoprotective Effects, Bull. Korean Chem. Soc., 28(6), 970-976, 2007
11. Zhao L. X., Sherchan J., Park J. K., Jahng Y. and Lee E. S.; Synthesis, Cytotoxicity and Structure-Activity Relationship Study of Terpyridines,
Archives of PharmacalResearch, 29(12), 1091-1095, 2006
12. 張雪蓮，廖世軍，劉軍民， 趙龍鉉; 高含鋯量的中孔分子篩 Zr-MSU-V 的合成與表征; 分子催化, 20(5), 414-418, 2006
13. Zhao L. X., Yun M. K., Kim H. O., Lee J. A., Choi W. J., Lee K. M., Lee S. K., Lee Y. B., Ahn C. H. and Jeong L. S., Design, Synthesis, and
Anticancer Activity of Fluorocyclopentenyl-pyrimidines, Nucleic Acids Symposium Series, 49, 107-108, 2005
14. Zhao L. X., Park J. G., Moon Y. S., Basnet A. and Lee E. S.; Design，Synthesis and Anticonvulsive Activity of Analogs of γ–Vinyl GABA, IL
FARMACO, 59, 381-388, 2004
15.Jahng Y. D., Zhao L. X., Moon Y. S., Basnet A. and Lee E. S.; Simple aromatic compounds containing propenone moiety show considerable dual
COX/5-LOX inhibitory activities, Bioorg . Med. Chem. Lett. 14, 2559-2562, 2004
16. Zhao L. X., Moon Y. S., Basnet A., Kim E. K. and Lee E. S.; Synthesis, Topoisomerase I inhibition and Structure-activity Relationship Study of
2,4,6-Trisubstituted Pyridine Derivatives, Bioorg . Med. Chem. Lett. 14, 1333-1337, 2004
17. Dong M. S., Jung S. H., Kim H. J., Kim J. R., Zhao L. X. and Lee E. S.; Structure-Related Cytotoxicity and Anti-Hepatofibric Effect of Asiatic Acid
Derivatives in Rat hepatic Stellate Cell-Line, HSC-T6, Archives of PharmacalResearch, 27(5), 512-517, 2004
18. Zhao L. X., Moon Y. S., Basnet A. and Lee E. S.; Design, Synthesis and Anticonvulsive Activities of Potential Prodrugs Linked by Two-carbon
Chain, Archives of PharmacalResearch, 26(10), 785-795, 2003
19. Zhao L. X., Kim E. K., Lim H. T., Moon Y. S.and Lee E. S.; Synthesis, Characterization and In VitroIdentification of N-Guanine Adduct of 2-
Bromopropane, Archives of PharmacalResearch, 25(1), 39-44, 2002
20.Lim H. T., Moon Y. S., Zhao L. X., Kim E. K. and Lee E. S.; Synthesis of 7-Isopropyl Guanine as Potential DNA Adduct Derived from 2-
Bromopropane, Journal of Resource Development, 20(1), 133-137, 2002
-21. Zhao L. X., Kim T. S., Ahn S. H., Kim T. H., Kim E. K.and Lee E. S.; Synthesis, Topoisomerase I Inhibition and Antitumor Cytotoxicity of 2,2’:6’,2”-, 2,2’:6’,3”- and 2,2’:6’,4”-Terpyridine Derivatives, Bioorg . Med. Chem. Lett.11, 2659-2662， 2001
22. Zhao L. X. and Lee E. S.; Synthesis of Potential Hepatoprotective Agents and Their Biological Activities, Journal of Resource Development, 20(1), 51-59, 2001
23. Zhao L. X., Kim E. K. and Lee E. S.; Asymmetric Synthesis of 2-Oxiraneboxylate Intermediate, Journal of Resource Development, 20(1), 79-86, 2001
24. Ahn S. H., Kim T. H., Zhao L. X., Kim E. K. and Lee E. S.; Synthesis and in vitro Cytotoxicity of Terpyridine Derivatives. Journal of Resource
Development, 20(1), 109-118 , 2001
25. Kim Y. C., Zhao L. X.,Kim T. H., Je S. M. and Lee E. S.; Design and Synthesis of Anticonvulsive Agents as -Vinyl GABA-Based Potential Dual Acting Prodrugs and their Biological Activities, Bioorg . Med. Chem. Lett. 10, 609-613, 2000
-26. Jew S. S., Kim E. K., Je S. M., Zhao L. X. and Lee E. S.; Design and Synthesis of 2-Oxiranecarboxylate Derivatives and their Hypoglycemic
Activities, Heterocycles , 52(3), 1087， 2000
近年來在國際學術會上發表的論文：
- Pal S., Zhao L. X., Park Y. H., Jeon J. H., Choi W. J., Lee S. K. and Jeong L. S., Design, Synthesis, and Anticancer Activity of Fluorocyclopentenyl-pyrimidines， 6th AFMC International Medicinal Chemistry Symposium, Istanbul, Turkey，July 08-11， 2007
- Jeong L. S., Zhao L. X., Yun M. K., Choi W. J., Lee S. K., Lee K. M, Lee Y. B., Ahn C. H., Synthesis and Anti-tumor Activity of Fluorocyclopentenyl-pyrimidines, 230th American Chemical Society Meeting, Abstracts, Washington, DC, U. S. A., Aug. 28-Sept. 1, 2005
- Zhao L. X., Yun M. K., Kim H. O., Lee J. A., Choi W. J., Lee K. M., Lee S. K., Lee Y. B., Ahn C. H. and Jeong L. S., Design, Synthesis, and Anticancer Activity of Fluorocyclopentenyl-pyrimidines, 4th International Symposium on Nucleic Acids Chemistry(32nd Symposium on Nucleic Acids Chemistry in Japan), Fukuoka, Japan, September 20 – 22, 2005
- Zhao L. X., Jeong L. S., Design and Synthesis of Fluoropentenyl-pyrimidines as Potent Anticancer Agents, Proceeding of the Convention of the Pharmaceutical Society of Korea, Seoul Education Culture Center, Korea, November 28-29, 2005
- Park T.H., Lee S.H., Zhao L. X.; The generation of novel quinolone derivatives with antibacterial activity, 4th International Symposium on Antimicrobial Agents and Resistance, Seoul, Korea, July 16 – 18, 2003
- Lee E. S., Moon Y. S., Zhao L. X., Kim E. K., Lim H. T.; Synthesis, Characterization, In Vitro and calf Thymus DNA Identification of N-Guanine Adducts of 1- and 2-bromopropane, 42nd Annual Meeting Society of Toxicology, U. S. A., Mar. 11, 2003
- Zhao L. X., Kim E. K., Lim H. T., Moon Y. S., Kim N. H., Kim T. H., Choi H.S., Chae W. G., Jeong T. C. and Lee E. S.; Synthesis, Characterization and In VitroIdentification of N7-Guanine Adduct of 2-Bromopropane, 41st Annual Meeting Society of Toxicology, U. S. A, Mar. 19, 2002
- Lim H. T., Moon Y. S., Zhao L. X., Kim E. K., Lee E. S.; Synthesis of 2,6-Diaromatic Substituted Pyridine Derivatives and Their Antitumor Activities, Proceedings of the 51st annual convention of the pharmaceutical society of Korea, Oct. 17, 2002
- Moon Y. S., Lim H. T., Zhao L. X., Kim E. K., Lee E. S.; Design, Synthesis and Antitumor Evaluation of Terpyridine Derivatives Containing Pyridine at 4'-Position, Proceedings of the 51st annual convention of the pharmaceutical society of Korea, Oct. 17, 2002
- Zhao L. X., Kim E. K., Lim H. T., Moon Y. S., Kim N. H., Kim T. H., Choi H.S., Chae W. G., Jeong T. C. and Lee E. S.; Synthesis, Characterization, and In Vitroand Calf Thymus DNA Identification of N7-Guanine Adduct of 2-Bromopropane, Proceedings of the Spring Convention of the Pharmaceutical Society of Korea, April. 19, 2002
- Lee E. S., Zhao L. X., Ahn S. H., Kim E. K., Cho W. J., Kim T. S., Lee C. S., Lim H. T.; Synthesis of terpyridine derivatives and their topoisomerase I inhibitory activities. 221th American Chemical Society Meeting, Abstracts, San Diego, U. S. A., Mar. 31-April 5, 2001
- Lee E. S., Kim J. A., Lee Y. S., Jin D. Q., Zhao L. X.; Asiatic acid, a component of Centella asiatica, and its derivatives induce appotosis in human liver cells, International Conference on Dietary Factors: Cancer Causes & Prevention, Vienna, Austria, Feb. 14, 2001
- Lee E. S., Chang C. J., Kim E. K., Kim J. A., Ahn S. H., Zhao L. X.; Synthesis and antitumor activity of terpyridine derivatives. 219th AmercianChemical Society Meeting, Abstracts, San Francisco, U. S. A., Mar. 26-31, 2000
- Lee E. S., Park H. G., Jew S. S., Ryu J. H., Kim Y. C., Lee M. K., Choi J. W., Kim T. H., Zhao L. X. and Jahng Y. D.; Structure-activity relationship study of asiatic acid derivatives against carbontetrachloride or galactosamine-induced hepatotoxicity, 219th AmercianChemical Society Meeting, Abstracts, San Francisco, U. S. A., Mar. 26-31, 2000
- Lee E. S., Kim E. K., Kim J. A., Kim T. H., Ahn S. H., Zhao L. X., Choe J. W.; Synthesis of Pyridine, Thiophene and Furan-containing Compounds and their Antitumor Activities. The Spring Convention of the Pharmaceutical Society of Korea, April 21, 2000
- Zhao L. X.,Ahn S. H., Kim J. A., Lee E. S.; Terpyridine Derivatives: Potential Antitumor Agents, The 48th Annual Convention of the Pharmaceutical Society of Korea & International Symposium, April 21, 2000
