王保民[大連理工大學製藥科學與技術學院教授]

性別:男。現為大連理工大學化工學部製藥科學與技術學院教授、博士生導師。招生專業:有機化學(理學)、藥物工程(理學)、套用化學(工科)。

個人簡歷

1992-1996: 本科,蘭州大學化學系
1996-1999: 碩士,蘭州大學 & 中科院上海有機所)(塗永強院士&馬大為研究員)
2000-2003: 博士,蘭州大學功能有機分子化學國家重點實驗室(師從塗永強院士)
1999-2005: 助教、講師、副教授,蘭州大學
2004-2005: 博士後,法國巴黎第五大學藥學院
2005-2007: 博士後,美國Brandeis大學化學系(Deng Li教授)
2007.9-至今:教授,博士生導師(2009.7-),大連理工大學

研究領域

導向天然產物及藥物合成的有機合成方法學,不對稱催化

具有生物活性的天然產物的全合成

藥物合成

1.

導向天然產物及藥物合成的有機合成方法學,不對稱催化

2.

具有生物活性的天然產物的全合成

3.

藥物合成

王保民 教授,博士生導師,從2007年起一直從事有機合成方法學及天然產物全合成方面的研究。開發了一系列新型基於酒石酸骨架的手性胍催化劑,並建立了雙功能不對稱催化的新體系,通過發揮其協同催化作用,在溫和條件下,實現高選擇性的不對稱碳碳鍵生成反應、氫轉移還原反應、不對稱氟化、氧化等反應。特別是一步反應同時構建多手性中心的方法,可有效地套用在多種手性藥物和天然產物的合成上。另外,該課題組還致力於金屬催化的有機氟化學、碳氫鍵活化、多組分反應等方面的研究,並已取得了很好的結果 。截至2014年,已在Nature Chemistry.,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Acc. Chem. Res., Org. Lett.,Chem. Commun等國際知名期刊上發表論文若干。

出版著作

Liwei Zou, Xiaoze Bao, Yuanyuan Ma, Yuming Song, Jingping Qu, and Baomin Wang*. Chem. Commun., 2014, Accepted Manuscript, DOI: 10.1039/C4CC01817F.

Liwei Zou, Xiaoze Bao, Huanrui Zhang, Yuming Song, jingping Qu, and Baomin Wang*. Aust. J. Chem., 2014, under review. (Invited paper for a Research Front issue on “The chemistry of guanidine, guanidinium and guanidinate compounds”)

Liwei Zou, Baomin Wang*, Hongfang Mu, Huanrui Zhang, Yuming Song, and Jingping Qu*.Org. Lett., 2013, 15, 3106–3109

Baomin Wang and Yong Qiang Tu. Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Acc. Chem. Res., 2011, 44 (11), pp 1207–1222.

Baomin Wang, Fanghui Wu, Yi Wang, Xiaofeng Liu, and Li Deng “Control of Diastereoselectivity in Tandem Asymmetric Reactions Generating Nonadjacent Stereocenters with Bifunctional Catalysis by Cinchona Alkaloids” J. Am. Chem. Soc. 2007, 129, 768-769.

Hongming Li, Baomin Wang, and Li Deng “Enantioselective Nitroaldol Rearction of α-Ketoesters Catalyzed by Cinchona Alkaloids” J. Am. Chem. Soc. 2006, 128, 732-733.

Min Wang, Bao Min Wang, Lei Shi, Yong Qiang Tu, Chun-An Fan, Shao Hua Wang, Xiang Dong Hu, and Shu Yu Zhang “Quinine/Selectfluor Combination Induced Asymmetric Semipinacol Rearrangement of Allylic Alcohols: An Effective and Enantioselective Approach to α-Quaternary β-Fluoro Aldehydes” Chem. Commun. 2005, 5580-5582.

Baomin Wang, Martine Bonin, and Laurent Micouin “A Straightforward Synthesis of Ynone by Reaction of Dimethylalkynylaluminum Reagents with Acid Chlorides” J. Org. Chem. 2005, 70, 6126-6170.

Baomin Wang, Martine Bonin, and Laurent Micouin “Palladium-Catalyzed Cross-Coupling of Aryl Electrophiles with Dimethylalkynylaluminum Reagents” Org. Lett. 2004, 6, 3481-3484.

Bao Min Wang, Zhen Lei Song, Chun An Fan, Yong Qiang Tu, Wei Ming Chen “Halogen Cation Induced Stereoselective Semipinacol-type Rearrangement of Allylic Alcohols: A Highly Efficient Approach to α-Quaternary β-Haloketo Compounds” Synlett 2003, 1497-1499.

Zhen Lei Song, Bao Min Wang, Yong Qiang Tu, Chun An Fan, and Shu Yu Zhang “A General Efficient Strategy for cis-3a Aryloctahydroindole Alkaloids via Stereocontrolled ZnBr2-Catalyzed Rearrangement of 2,3-Aziridino Alcohols” Org. Lett. 2003, 5, 2319-2321.

Bao Min Wang, Zhen Lei Song, Chun An Fan, Yong Qiang Tu, and Yian Shi “Lewis Acid Promoted Highly Stereoselective Rearrangement of 2,3-Aziridino Alcohols: A New Efficient Approach to β-Amino Carbonyl Compounds” Org. Lett. 2002, 4, 363-366.

Chun-An Fan, Bao-Min Wang, Yong-Qiang Tu, and Zhen-Lei Song “Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of α-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1,3-Diol Units” Angew. Chem. Int. Ed. 2001, 40, 3877-3880

1.

Liwei Zou, Xiaoze Bao, Yuanyuan Ma, Yuming Song, Jingping Qu, and Baomin Wang*. Chem. Commun., 2014, Accepted Manuscript, DOI: 10.1039/C4CC01817F.

2.

3.

Liwei Zou, Baomin Wang*, Hongfang Mu, Huanrui Zhang, Yuming Song, and Jingping Qu*.Org. Lett., 2013, 15, 3106–3109

4.

Baomin Wang and Yong Qiang Tu. Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Acc. Chem. Res., 2011, 44 (11), pp 1207–1222.

5.

Baomin Wang, Fanghui Wu, Yi Wang, Xiaofeng Liu, and Li Deng “Control of Diastereoselectivity in Tandem Asymmetric Reactions Generating Nonadjacent Stereocenters with Bifunctional Catalysis by Cinchona Alkaloids” J. Am. Chem. Soc. 2007, 129, 768-769.

6.

Hongming Li, Baomin Wang, and Li Deng “Enantioselective Nitroaldol Rearction of α-Ketoesters Catalyzed by Cinchona Alkaloids” J. Am. Chem. Soc. 2006, 128, 732-733.

7.

Min Wang, Bao Min Wang, Lei Shi, Yong Qiang Tu, Chun-An Fan, Shao Hua Wang, Xiang Dong Hu, and Shu Yu Zhang “Quinine/Selectfluor Combination Induced Asymmetric Semipinacol Rearrangement of Allylic Alcohols: An Effective and Enantioselective Approach to α-Quaternary β-Fluoro Aldehydes” Chem. Commun. 2005, 5580-5582.

8.

Baomin Wang, Martine Bonin, and Laurent Micouin “A Straightforward Synthesis of Ynone by Reaction of Dimethylalkynylaluminum Reagents with Acid Chlorides” J. Org. Chem. 2005, 70, 6126-6170.

9.

Baomin Wang, Martine Bonin, and Laurent Micouin “Palladium-Catalyzed Cross-Coupling of Aryl Electrophiles with Dimethylalkynylaluminum Reagents” Org. Lett. 2004, 6, 3481-3484.

10.

Bao Min Wang, Zhen Lei Song, Chun An Fan, Yong Qiang Tu, Wei Ming Chen “Halogen Cation Induced Stereoselective Semipinacol-type Rearrangement of Allylic Alcohols: A Highly Efficient Approach to α-Quaternary β-Haloketo Compounds” Synlett 2003, 1497-1499.

11.

Zhen Lei Song, Bao Min Wang, Yong Qiang Tu, Chun An Fan, and Shu Yu Zhang “A General Efficient Strategy for cis-3a Aryloctahydroindole Alkaloids via Stereocontrolled ZnBr2-Catalyzed Rearrangement of 2,3-Aziridino Alcohols” Org. Lett. 2003, 5, 2319-2321.

12.

Bao Min Wang, Zhen Lei Song, Chun An Fan, Yong Qiang Tu, and Yian Shi “Lewis Acid Promoted Highly Stereoselective Rearrangement of 2,3-Aziridino Alcohols: A New Efficient Approach to β-Amino Carbonyl Compounds” Org. Lett. 2002, 4, 363-366.

13.

Chun-An Fan, Bao-Min Wang, Yong-Qiang Tu, and Zhen-Lei Song “Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of α-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1,3-Diol Units” Angew. Chem. Int. Ed. 2001, 40, 3877-3880

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