黃震[四川大學教授]

黃震 教授。他是中美化學及化學生物學教授協會(CAPA) 第一任主席，以及三位創始人之一。他為學術界做了很多工作,為中美學術和科技交流做出了積極貢獻。他被選為中國和美國聯邦政府研究基金的評審員以及國際多種高端學術刊物的評審員。他曾擔任多本書藉刊物的編輯或客座編輯。黃震教授曾就讀於四川大學、北京大學、瑞士蘇黎世聯邦理工大學，以及哈佛大學醫學院，師從2009年諾貝爾醫學獎得主傑克·邵斯達克(Jack Szostak)教授。 他是硒核酸、RNA核酸基因晶片、硒核酸生物平台技術及其硒核酸晶體結構研究的獨創發明人。他在《美國化學會雜誌》，《德國套用化學》，《核酸研究》及其他專業雜誌和刊物上發表文章100多篇。他的研究項目多次獲獎。他曾獨立獲得21項研究基金，其中包括美國聯邦政府研究基金、美國喬治亞州政府研究基金、癌症研究傑出專家基金和企業界研究基金的支持。其研究項目已經獲得或正在申請中國、美國、歐洲及國際專利及發明（30多項）。他也使用自己發明的創新技術來積極推動大核酸產業的發展以及生物醫藥技術的進步。

工作經歷

1980-1984年，獲得四川大學學士學位，分析化學專業

1984-1987年，獲得北京大學碩士學位，生物有機化學專業

1988-1994年，獲得瑞士蘇黎世聯邦理工大學（ETH, Zurich)博士學位，化學生物學專業。

1994-1998年，哈佛大學醫學院遺傳系博士後,從師於2009年諾貝爾醫學獎得主邵斯達克教授(Professor Jack Szostak)

1998年, 被聘入紐約城市大學布魯克倫學院為助理教授

2004年, 升為副教授，並被聘入喬治亞州立大學化學系

2009年, 升為喬治亞州立大學終身正教授,獲大學傑出教授獎，並為美國喬治亞州癌症研究傑出研究員

2014–今，四川大學生命科學學院正教授

學術兼職

2007 – 2010 中美化學及化學生物學教授協會（CAPA）第一任主席

2007 –今 美國癌症研究協會成員

2006 –今 美國晶體學協會成員

2002-2004 美國青年化學家協會（YACS）主席

1997-1998 美國華人生物化學家協會（ABC）主席

1994-今 美國化學學會成員

研究方向

目前他的主要研究興趣包括:硒核酸以及碲核酸創新性研究,包括生物化學合成,核糖核酸衍生化和核酸及核酸-蛋白複合物晶體結構及功能研究，以核酸和核酸-蛋白複合物結構測定為基礎的新藥研發，核酸適配體和核酶的篩選及功能研究，疾病的核酸檢測診斷，核酸基因測序，高保真鹼基識別與RNA晶片，核酸抗腫瘤藥物研究。

獲得獎勵

2010 –今 中國科學化學編委會成員

2008-2013喬治亞州癌症研究傑出科學家獎（GCC）

2008喬治亞州立大學傑出教授獎

2008喬治亞州立大學教授成就獎

2008 CAPA傑出教授獎

教學經驗

1.核酸的化學和生物合成，抗癌藥物的發現，核酸-蛋白大分子結構，機理研究和核酸檢測

2.化學和藥物治療

3.高級化學生物學和生物有機化學

4.高級有機合成和機理

部分申請和已獲得的專利：

1. Zhen Huang, Title: “RNA MICROCHIP DETECTION USING NANOPARTICLE-ASSISTED SIGNAL AMPLIFICATION”, 2014, PCT, filed.

2. Zhen Huang, Title: “METHODS AND COMPOSITIONS FOR INTERFERENCE WITH DNA POLYMERASE AND DNA SYNTHESIS”, 2013, US provisional application, filed.

3. Zhen Huang, Title: “NANOPARTICLE-ASSISTED RAPID RNA DETECTION ON RNA MICROARRAY”, 2013, US provisional application, filed.

4. Zhen Huang, Title: “Facile SELENIUM CONTAINING NUCLEOSIDES AS NUTRITIONAL SUPPLEMENTS”, 2013, PCT, filed.

5. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2013, Chinese Patent pending.

6. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2013, US Patent, 8,354,524.

7. Zhen Huang, Title: “RNA Selective Detection and Quantitation Using Chip and Plate”, 2012, European Patent 1668158.

8. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent 12/562,960.

9. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2011, US Patent Application (divisional), 13/172,559.

10. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, U.S. Provisional Application No.: 61/375,992.

11. Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2010, U.S. Patent Application No. 12/933,619 (National Phase Filing of PCT/US09/37823).

12. Zhen Huang, Title: “Facile Synthesis of Natural and Unnatural Nucleoside 5’-Triphosphates”, 2010, US provisional patent, 61/375,560.

13. Zhen Huang, Title: “RNA Detection and Quantitation”, 2010, Oct. 20, European Patent, WO 2005/019469.

14. Zhen Huang, Title: “Ultraviolet and High-Performance Liquid Chromatography Methods for the Evaluation of Sunscreen Efficacy”, 2010, US provisional patent, 61/382,154.

15. Zhen Huang, Jia Sheng, Title: “Novel Compounds and Synthesis of Tellurium-derivatized Oligonucleotides for Structural and Functional Studies”, 2010, PCT/US10/36639.

16. Zhen Huang, Abdalla Hassan, Jia Sheng and Wen Zhang, Title: “Novel Compound and Derivatizaton of DNAs and RNAs on the Nucleobases of Pyrimidines for Function, Structure and Therapeutics”, 2010, PCT/US10/35631.

17. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2010, US Patent, US7,982,030.

18. Zhen Huang, Title: “Synthesis of Selenium-Derivatized Nucleosides, Nucleotides, Phosphoramidites, Triphosphates and Nucleic Acids”, 2009, US Patent, US 7,592,446.

19. . Zhen Huang, Abdalla Hassan and Wen Zhang, Title: “Derivatization of DNAs and RNAs at 5-positions of pyrimidines for function, structure, and therapeutics”, 2009, US Provisional Patent Application, 60/180,028.

20. Zhen Huang, Jia Sheng and Abdalla Hassan, Title: “Novel Compounds and Derivatization of DNAs and RNAs at the 2' and 5-positions of pyrimidines with tellurium functionalities for function, structure, imaging, diagnosis, and therapeutics”, 2009, US Provisional Patent Application, 61/182,580.

21. Zhen Huang and Sarah Spencer, Title: “RNA Microchip for Rapid, Direct and Specific Detection of RNAs”, 2009, US Provisional Patent Application, 61/252,940

22. Zhen Huang and Jia Sheng, Title: “Improved Method and Process for Synthesis of 2’,3’-Didehyro-2’,3’-dideoxynucleosides (d4Ns)”, 2009, PCT Patent Application, International application No. PCT/US2009/037823.

23. Zhen Huang, Title: “Se-containing nucleosides, synthesis methods, and anti-cancer activity”, 2008, US Provisional Patent Application, 61/083,815.

代表性論文：

24. Liqin Zhang, Zunyi Yang, Kwame Sefah, Kevin M. Bradley, Shuichi Hoshika, Myong-Jung Kim, Hyo-Joong Kim, Guizhi Zhu, Sena Cansiz, I-Ting Teng, Carole Champanhac, Christopher McLendon, Chen Liu, Wen Zhang, Dietlind L. Gerloff 3, Zhen Huang, Weihong Tan and Steven A. Benner, “Crystal Structure, Evolution, and Function of Six-Nucleotide DNA. Exploring its Large Sequence Space” ， Journal of American Chemical Society, 2015, 137, 6734−6737.

25. Rob Abdur, Oksana O. Gerlits, Jianhua Gan, Jiansheng Jiang, Jozef Salon, Andrey Y. Kovalevsky, Alexander Chumanevich, Irene T. Weber, Zhen Huang*, “Novel Complex MAD Phasing and RNase H Structural Insights by Selenium Oligonucleotides”, Acta Crystallographica Section D, 2014, D70, 354-361.

26. Jia Sheng, Jianhua Gan, Alexie Soars, Jozef Salon and Zhen Huang*, “Structural Insights of Non-canonical U·U Pair and Hoogsteen Interaction Probed with Se Atom”, 2013, Nucleic Acids Research, 41, 10476-10487.

27. Jia Sheng, Jianhua Gan and Zhen Huang*, “Structure-Based DNA-Targeting Strategies with Small Molecule Ligands for Drug Discovery”, Medicinal Research Reviews, 2013, 33, 1119-1173.

28. Huiyan Sun, Sibo Jiang, Julianne Caton-Williams, Hehua Liu, and Zhen Huang*, “2-Selenouridine Triphosphate Synthesis and Se-RNA Transcription”, RNA, 2013, 19, 1309-1314 .

29. Jia Sheng, Wen Zhang, Abdalla E. A. Hassan, Jianhua Gan, Alexei Soares, Song Geng, Yi Ren, Zhen Huang*, "Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone", Nucleic Acids Research, 2012, 40, 8111-8118.

30. Huiyan Sun, Jia Sheng, Abdalla E. A. Hassan, Sibo Jiang, Jianhua Gan and Zhen Huang*, “Novel RNA Base Pair with Higher Specificity using Single Selenium Atom”, Nucleic Acids Res., 2012, 40, 5171-5179.

31. Wen Zhang, Jia Sheng, Abdalla E. Hassan, and Zhen Huang*, "Synthesis of Novel 2’-Deoxy-5-(Methylselenyl)Cytidine and Se-DNAs for Structure and Function Studies", Chemistry-An Asian Journal, 2012, 7, 476-479.

32. Jia Sheng, Abdalla E. A. Hassan, Wen Zhang, Jianfeng Zhou, Bingqian Xu, Alexei S. Soares and Zhen Huang*, "Synthesis, Structure and Imaging of Oligodeoxyribonucleotides with Tellurium-nucleobase Derivatization", Nucleic Acids Research, 2011, 39, 3962-3971.

33. Wen Zhang and Zhen Huang*, "Synthesis of the 5’-Se-Thymidine Phosphoramidite and Convenient Labeling of DNA Oligonucleotide", Organic Letter, 2011, 13, 2000-2003.

34. Julianne Caton-Williams, Lina Lin,Mathew Smith, and Zhen Huang*, "Convenient Synthesis of Nucleoside 5’-Triphosphates for RNA Transcription", Chemical Communications, 2011, 47, 8142-8144.

35. Lina Lin, Julianne Caton-Williams, Manindar Kaur, Andres M. Patino, Jia Sheng, Jaya Punetha, and Zhen Huang*, "Facile Synthesis of Nucleoside 5’-(alpha-P-seleno)-triphosphates and Phosphoroselenoate RNA Transcription", RNA, 2011, 1932-1938.

36. Lina Lin, Jia Sheng, and Zhen Huang*, "Nucleic Acid X-ray Crystallography via Direct Selenium Derivatization", Chemical Society Reviews (invited and peer reviewed), 2011, 40, 4591-4602.

37. Khin Lay Maw, Julianne Caton-Williams, Jozef Salon, Zhen Huang*, "Simple UV and HPLC Methods for the Evaluation of Sunscreen Efficacy", Journal of the American Academy of Dermatology, 2011, 65, 328-335. ##

38. Abdalla E. A. Hassan, Jia Sheng, Wen Zhang, and Zhen Huang*, "High Fidelity of Base Paring by 2-Selenothymidine in DNA", Journal of American Chemical Society, 2010, 132, 2120-2121. ##

39. Jia Sheng, Abdalla Hassan, Zhen Huang*, "Synthesis of the First Tellurium-Derivatized Oligonucleotides for Structural and Functional Studies", Chemistry - A European Journal, 2009, 15, 10210-10216. ##

40. Julianne Caton-Williams and Zhen Huang*, "Synthesis of Colored 4-Selenothymidine Triphosphate and its DNA Polymerase Incorporation into DNAs for Visualization, Structure and Function Studies", Angew. Chem. Int. Ed., 2008, 47, 1723-1725. ##

41. Jozef Salon, Jiansheng Jiang, Jia Sheng, Oksana O. Gerlits, Zhen Huang*, "Derivatization of DNAs with Selenium at 6-Position of Guanine for Function and Crystal Structure Studies", Nucleic Acids Research, 2008, 36, 7009-7018. ##

42. Jozef Salon, Jia Sheng, Jiansheng Jiang, Guexiong Chen, Julianne Caton-Williams, Zhen Huang*, “Oxygen Replacement with Selenium at the Thymidine 4-position for the Se-Base-Paring and Crystal Structure Studies”, Journal of American Chemical Society, 2007, 129, 4862-4863. ##

43. Jiansheng Jiang, Jia Sheng, Nicolas Carrasco, and Zhen Huang*, “Selenium Derivatization of Nucleic Acids for Crystallography”, Nucleic Acids Research, 2007, 35, 477-485. ##

44. Jozef Salon, Guexiong Chen, Yoani Portilla, Markus W. Germann, and Zhen Huang*, “Synthesis of a Novel 2’-Se-uridine Phosphoramidite and Its Incorporation into Oligonucleotides for Structure Study”, Organic Letters, 2005, 7, 5645-5648. ##

45. Nicolas Carrasco and Zhen Huang*, “Enzymatic Synthesis of Phosphoroselenoate DNA using Thymidine 5’-(a-P-Seleno)-triphosphate and DNA Polymerase for X-ray Crystallography using MAD”, Journal of American Chemical Society, 2004, 126, 448-449. #

46. Nicolas Carrasco, Yuri Buzin, Elizabeth Tyson, Elizer Halpert, and Zhen Huang*, “ Selenium Derivatization and Crystallization of DNA and RNA Oligonucleotides for X-ray Crystallography Using Multiple Anomalous Dispersion”, Nucleic Acids Research, 2004, 32, 1638-1646. #

47. Zhen Huang* and Jack W. Szostak, “Evolution of Aptamers with a New Specificity and New Secondary Structures from an ATP Aptamer”, RNA, 2003, 9 , 1456-1463 . #

48. Quan Du, Nicolas Carrasco, Marianna Teplova, Christopher J. Wilds, Martin Egli, and Zhen Huang*, “Internal Derivatization of Oligonucleotides with Selenium for X-ray Crystallography Using MAD”, Journal of American Chemical Society, 2002, 124, 24-25. #

49. Nicolas Carrasco, Dov Ginsburg, Quan Du, and Zhen Huang*, “Synthesis of Selenium-Derivatized Nucleosides and Oligonucleotides for X-ray Crystallography”, Nucleosides, Nucleotides, & Nucleic Acids, 2001, 20, 1723-1734.